Scavenger Receptor class B type i (SR-BI): A versatile receptor with multiple functions and actions

Metabolism: Clinical and Experimental

Volumn 63, Issue 7, 2014, Pages 875-886

  Shen, Wen Jun ^a,b   Hu, Jie ^a   Hu, Zhigang ^a,b,c   Kraemer, Fredric B ^a,b   Azhar, Salman ^a,b  

^a GERIATRIC RESEARCH EDUCATION AND CLINICAL CENTER   (United States)

^b STANFORD UNIVERSITY   (United States)

^c NANJING NORMAL UNIVERSITY   (China)

Author keywords

HDL receptor; Selective uptake; Steroid hormones

Indexed keywords

CD36 ANTIGEN; SCAVENGER RECEPTOR BI;

GENE EXPRESSION; HUMAN; MOLECULAR MECHANICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENETIC TREE; POSTTRANSCRIPTIONAL GENE SILENCING; PRIORITY JOURNAL; PROTEIN PROCESSING; REVIEW;

HDL RECEPTOR; SELECTIVE UPTAKE; STEROID HORMONES;

ANIMALS; BIOLOGICAL TRANSPORT; GENE EXPRESSION REGULATION; GLYCOSYLATION; HUMANS; INSECT PROTEINS; LIPOPROTEINS, HDL; LIVER; ORGAN SPECIFICITY; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, LIPOPROTEIN; SCAVENGER RECEPTORS, CLASS B; SPECIES SPECIFICITY;

EID: 84902536862     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2014.03.011     Document Type: Review

References (133)

1. S. Acton, A. Rigotti, and K. Landschultz et al. Identification of scavenger receptor SR-BI as a high density lipoprotein receptor Science 271 1996 518 520
2. S. Azhar, S. Leers-Sucheta, and E. Reaven Cholesterol uptake is adrenal and gonadal tissues: the SR-BI and "selective" pathway connection Front Biosci 8 2003 s998 s1029
3. M. Connelly, S. Klein, and S. Azhar et al. Comparison of class B scavenger receptors, CD36, and scavenger receptor BI (SR-BI), shows that both receptors mediate high-density lipoprotein-cholesteryl ester selective uptake but SR-BI exhibits a unique enhancement of cholesteryl ester uptake J Biol Chem 274 1999 41 47
4. S. Azhar, A. Nomoto, and S. Leers-Sucheta et al. Simultaneous induction of an HDL receptor protein (SR-BI) and the selective uptake of HDL-cholesteryl esters in a physiologically relevant steroiodgenic cell model J Lipid Res 39 1998 1616 1628
5. A. During, H. Dawson, and E. Harrison Carotenoid transport is decreased and expression of the lipid transporters SR-BI, npc1l1, and abca1 is downregulated in caco-2 cells treated with ezetimibe J Nutr 135 2005 2305 2312
6. E. Reboul, A. Klein, and F. Bietrix et al. Scavenger receptor class B type I (SR-BI) is involved in vitamin e transport across the enterocyte J Biol Chem 281 2006 4739 4745
7. A. Rigotti, S. Acton, and M. Krieger The class B scavenger receptors SR-BI and CD36 are receptors for anionic phospholipids J Biol Chem 270 27 1995 16221 16224
8. S. Saddar, V. Carriere, and W. Lee et al. Scavenger receptor class B type I (SR-BI) is a plasma membrane cholesterol sensor Circ Res 112 1 2013 140 151
9. M. Burlone, and A. Budkowska Hepatitis C virus cell entery: role of lipoproteins and cellular receptors J Gen Virol 90 2009 1055 1070
10. H. Barth, E. Schnober, and C. Neumann-Haefelin et al. Scavenger receptor class B is required for hepatitis c virus uptake and cross-presentation by human dendritic cells J Virol 82 7 2008 3466 3479
11. Y. Osada, T. Sunatani, and I. Kim et al. Signalling pathway involving gulp, mapk and rac1 for SR-BI-induced phagocytosis of apoptotic cells J Biochem 145 3 2009 387 394
12. H. Miettinen, H. Rayburn, and M. Krieger Abnormal lipoprotein metabolism and reversible female infertility in HDL receptor (SR-BI)-deficient mice J Clin Invest 108 11 2001 1717 1722
13. Y. Ma, M. Ashraf, and E. Podrez Scavenger receptor BI modulates platelet reactivity and thrombosis in dyslipidemia Blood 116 11 2010 1932 1941
14. A. Zimman, and E. Podrez Regulation of platelet function by class B scavenger receptors in hyperlipidemia Arterioscler Thromb Vasc Biol 30 2010 2350 2356
15. A. Al-Jarallah, and B. Trigatti A role for the scavenger receptor, class B type I in high density lipoprotein dependent activation of cellular signaling pathways Biochim Biophys Acta 2010 1801 1239 1249
16. S.M.C. Saddar, and P.W. Shaul Signaling by the high-affinity HDL receptor B type I Arterioscler Thromb Vasc Biol 30 2010 144 150
17. Y. Pei, X. Chen, and D. Aboutouk et al. SR-BI in bone marrow derived cells protects mice from diet induced coronary artery atherosclerosis and myocardial infarction PLoS One 8 8 2013 e72492
18. M. Viñals, S. Xu, and E. Vasile et al. Identification of the n-linked glycosylation sites on the high density lipoprotein (HDL) receptor SR-BI and assessment of the effects on HDL binding and selective lipid uptake J Biol Chem 278 2003 5325 5332
19. N. Tao, S. Wagner, and D. Lublin Cd36 is palmitoylated on both n- and c-terminal cytoplasmic tails J Biol Chem 271 1996 22315 22320
20. J. Babitt, B. Trigatti, and A. Rigotti et al. Murine SR-BI, a high density lipoprotein receptor that mediates selective lipid uptake, is n-glycosylated and aftty acylated and colocalizes with plasma membrane caveolae J Biol Chem 272 1997 13242 13249
21. R. Thorne, K. Ralston, and C. deBock et al. Palmitoylation of CD36/fat regulates the rate of its post-transcriptional processing in the endoplasmic reticulum Biochim Biophys Acta 1803 2010 1298 1307
22. X. Wei, H. Song, and C.F. Semenkovitch Insulin-regulated protein palmitoylation impactsendothelial cell function Arterioscler Thromb Vasc Biol 34 2014 346 354
23. C. Glass, R. Pittman, and D. Weinstein et al. Dissociation of tissue uptake of cholesterol ester from that of apoprotein A-1 of rat plasma high density lipoprotein: selective delivery of cholesterol ester to liver, adrenal, and gonad Proc Natl Acad Sci U S A 80 1983 5435 5439
24. S. Azhar, D. Stewart, and E. Reaven Utilization of cholesterol-rich lipoproteins by perfused rat adrenals J Lipid Res 30 1989 1799 1810
25. J. Khoo, R. Pittman, and E. Rubin Selective uptake of HDL cholesteryl esters is active in transgenic mice expressing human apolipoprotein A-I J Lipid Res 36 1995 593 600
26. E. Reaven, L. Tsai, and S. Azhar Intracellular events in the selective transport of lipoprotein-derived cholesteryl esters J Biol Chem 271 1996 16208 16217
27. K. Landschulz, R. Pathak, and A. Rigotti et al. Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat J Clin Invest 98 1996 984 985
28. A. Rigotti, E. Edelmann, and P. Seifert et al. Regulation by adrenocorticotropic hormone of the in vivo expression of scavenger receptor class B type I (SR-BI), a high density lipoprotein receptor, in steroidogenic cells of the murine adrenal gland J Biol Chem 271 1996 33545 33549
29. E. Reaven, A. Nomoto, and S. Leers-Sucheta et al. Expression and microvillar localization of scavenger receptor, class B, type I (a high density lipoprotein receptor) in luteinized and hormone-desensitized rat ovarian models Endocrinology 139 1998 2847 2856
30. E. Reaven, L. Zhan, and A. Nomoto et al. Expression and microvillar localization of scavenger receptor class B, type I (SR-BI) and selective cholesteryl ester uptake in Leydig cells from rat testis J Lipid Res 41 2000 343 356
31. S. Azhar, A. Nomoto, and E. Reaven Hormonal regulation of adrenal microvillar channel formation J Lipid Res 43 2002 861 871
32. K. Fluiter, D. van der Westhuijzen, and T. van Berkel In vivo regulation of scavenger receptor BI and the selective uptake of high density lipoprotein cholesteryl esters in rat liver parenchymal and kupffer cells J Biol Chem 273 1998 8434 8438
33. Wu Q, Sucheta S, Azhar S, et al. Lipoprotein enhancement of ovarian theca-interstitial cell steroiodogensis: relative contribution of scavenger receptor class B (type I) and adenosine 5'-triphosphate-binding cassette (type a1) transporter in high-density lipoprotein-cholesterol transport and androgen synthesis. Endocrinology 144, 2003, 2437-2445.
34. S. Azhar, and E. Reaven Scavenger receptor class BI and selective cholesteryl ester uptake: partners in the regulation of steroidogenesis Mol Cell Endocrinol 195 2002 1 26
35. R. Rao, S. Leers-Sucheta, and H. Bose et al. Differential regulation of steroid hormone biosynthesis in r2c and ma-10 Leydig tumor cells: role of SR-BI-mediated selective choleryl ester transport Biol Reprod 68 2003 114 121
36. C. Wadsack, A. Hammer, and S. Levak-Frank et al. Selective cholesteryl ester uptake from high density lipoprotein by human first trimester and term villous trophoblast cells Placenta 24 2003 131 143
37. C. Wadsack, A. Hrzenjak, and A. Hammer et al. Traophoblast -like human chriocarcinoma cells serve as a suitable in vitro model for selective cholesteryl ester uptake from high density lipoproteins Eur J Biochem 270 2003 451 462
38. A. Nakagawa, K. Nagaosa, and T. Hirose et al. Expression and function of class B scavenger receptor type I on both apical and basolateral sides of the plasma membrane of polarized testicular sertoli cells of the rat Dev Growth Differ 46 2004 283 298
39. N. Webb, W. de Villiers, and F. de Beer et al. Alternate forms of the scavenger receptor BI (SR-BI) J Lipid Res 38 1997 1490 1495
40. J. Husamann, J. Loike, and R. Anankov et al. Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system Glia 40 2002 195 205
41. A. Tondu, C. Robichon, and L. Yvan-Charvet et al. Insulin and angiotensin induce the translocation of scavenger receptor class B, type I from intracellular sites to the plasma membrane of adipocytes J Biol Chem 280 2005 33536 33540
42. L. Yu, G. Cao, and J. Repa et al. Sterol regulation of scavenger receptor class B type I in macrophages J Lipid Res 45 2004 889 899
43. P. Svensson, M. Englund, and M. Snäckestrand et al. Regulation and splicing of scavenger receptor class B type I in human macrophages and atherosclerotic plaques BMC Cardiovasc Disord 5 2005 25
44. X. Yu, K. Murao, and H. Imachi et al. Regulation of scavenger receptor class BI gene expression by angiotensin ii in vascular endothelial cells Hypertension 49 2007 1378 1384
45. T. Kimura, C. Mogi, and H. Tomura et al. Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells J Immunol 181 2008 7332 7340
46. Y. Yeh, G. Hwang, and I. Liu et al. Identification and expression of scavenger receptor SR-BI in endothelial cells and smooth muscle cells of rat aorta in vitro and in vivo Atherosclerosis 161 2002 95 103
47. S. Cai, R. Kirby, and P. Howles et al. Differentiation-dependent expression and localization of the class B type I scavenger receptor in intestine J Lipid Res 42 2001 902 909
48. P. Voshol, M. Schwarz, and A. Rigotti et al. Down-regulation of intestinal scavenger receptor class B, type I (SR-BI) expression in rodents under conditions of deficient bile delivery to the intestine Biochem J 356 2001 317 325
49. K. Duncan, K. Bailey, and J. Kane et al. Human retinal pigment epithelial cells express scavenger receptors BI and BII Biochem Biophys Res Commun 292 2002 1017 1022
50. H. Tsuruoka, W. Khovidhunkit, and B. Brown et al. Scavenger receptor class B type I is expressed in cultured keratinocytes and epidermis. Regulation in response to changes in cholesterol homeostasis and barrier requirements J Biol Chem 277 2002 2916 2922
51. A. Duggan, R. Marie, and I. Callard Expression of SR-BI (scavenger receptor class B type I) in turtle (Chrysemys picta) tissues and other nonmammalian vertebrates J Exp Zool 292 5 2002 430 434
52. T. Means, E. Mylonakis, and E. Tampakakis et al. Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors scarf1 and CD36 J Exp Med 206 3 2009 637 653
53. T. Means Fungal pathogen recognition by scavenger receptors in nematodes and mammals Virulence 1 1 2010 37 41
54. H. Tanaka, J. Ishibashi, and K. Fujita et al. A genome-wide analysis of genes and gene families involved in innate immunity of Bombyx mori Insect Biochem Mol Biol 38 12 2008 1087 1110
55. T. Sakudoh, S. Kuwazaki, and T. Iizuka et al. CD36 homolog divergence is responsible for the selectivity of carotenoid species migration to the silk gland of the silkworm Bombyx mori J Lipid Res 54 2 2013 482 495
56. T. Sakudoh, T. Iizuka, and J. Narukawa et al. A CD36-related transmembrane protein is coordinated with an intracellular lipid-binding protein in selective carotenoid transport for cocoon coloration J Biol Chem 285 10 2010 7739 7751
57. L. Herboso, A. Talamillo, and C. Pérez et al. Expression of the scavenger receptor class B type I (SR-BI) family in Drosophila melanogaster Int J Dev Biol 55 6 2011 603 611
58. Z. Nichols, and R. Vogt The SNMP/CD36 gene family in Diptera, Hymenoptera and Coleoptera: Drosophila melanogaster, D. pseudoobscura, Anopheles gambiae, Aedes aegypti, Apis mellifera, and Tribolium castaneum Insect Biochem Mol Biol 38 4 2008 398 415
59. L. Gaidukov, A. Nager, and S. Xu et al. Glycine dimerization motif in the n-terminal transmembrane domain of the high density lipoprotein receptor SR-BI required for normal receptor oligomerization and lipid transport J Biol Chem 286 21 2011 18452 18464
60. D. Neculai, M. Schwake, and M. Ravichandran et al. Structure of limp-2 provides functional insights with implications for SR-BI and CD36 Nature 504 2013 172 176
61. J. Rasmussen, L. Berglund, and M. Rasmussen et al. Assignment of disulfide bridges in bovine CD36 Eur J Biochem 257 1998 488 494
62. Y. Miao, K. Romera, and T. Nieland et al. Exoplasmic cysteine cys384 of the HDL receptor SR-BI is critical for its sensitivity to a small-molecule inhibitor and normal lipid transport activity Proc Natl Acad Sci U S A 108 2011 12243 12248
63. G. Papale, P. Hanson, and D. Sahoo Extracellular disulfide bonds support scavenger receptor class B type I-mediated cholesterol transport Biochemistry 50 28 2011 6245 6254
64. M. Yu, T. Lau, and S. Carr et al. Contributions of a disulfide bond and a reduced cysteine side chain to the intrinsic activity of the high-density lipoprotein receptor SR-BI Biochemistry 51 50 2012 10044 10055
65. G. Cao, L. Zhao, and H. Stangl et al. Developmental and hormonal regulation of murine scavenger receptor, class B, type 1 Mol Endocrinol 13 9 1999 1460 1473
66. A. Rigotti, H. Miettinen, and M. Krieger The role of the high density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues Endocr Rev 24 2003 357 387
67. D. Spady, D. Kearney, and H. Hobbs Polyunsaturated fatty acids up-regulate hepatic scavenger receptor b1 (SR-BI) expression and HDL cholesteryl ester uptake in the hamster JLR 40 1999 1384 1394
68. C. Loison, F. Mendy, and C. Sérougne et al. Dietary myristic acid modifies the HDL-cholesterol concentration and liver scavenger receptor BI expression in the hamster Br J Nutr 87 2002 199 210
69. P. Mardones, A. Pilon, and M. Bouly et al. Fibrates down-regulate hepatic scavenger receptor class B type I protein expression in mice J Biol Chem 278 10 2003 7884 7890
70. Z. Hu, W. Shen, and F. Kraemer et al. Micrornas 125a and 455 repress lipoprotein-supported steroidogenesis by targeting scavenger receptor class B type I in steroidogenic cells Mol Cell Biol 32 24 2012 5035 5045
71. L. Wang, X.-J. Jia, and H.-J. Jiang et al. Micrornas 185, 96, and 223 repress selective high-density lipoprotein cholesterol uptake through posttranscriptional inhibition Mol Cell Biol 33 2013 1956 1964
72. X. Gu, B. Trigatti, and S. Xu et al. The efficient cellular uptake of high density lipoprotein lipids via scavenger receptor class B type I requires not only receptor-mediated surface binding but also receptor-specific lipid transfer mediated by its extracellular domain J Biol Chem 273 41 1998 26338 26348
73. B. Sun, B. Boyanovsky, and M. Connelly et al. Distinct mechanisms for oxldl uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI J Lipid Res 48 12 2007 2560 2570
74. M. Connelly, S. Klein, and S. Azhar et al. Comparison of class B scavenger receptors, CD36 and scavenger receptor BI (SR-BI), shows that both receptors mediate high density lipoprotein-cholesteryl ester selective uptake but SR-BI exhibits a unique enhancement of cholesteryl ester uptake J Biol Chem 274 1 1999 41 47
75. M. Yu, K. Romer, and T. Nieland et al. Exoplasmic cysteine cys384 of the HDL receptor SR-BI is critical for its sensitivity to a small-molecule inhibitor and normal lipid transport activity Proc Natl Acad Sci U S A 108 30 2011 12243 12248
76. A. Bocharov, I. Baranova, and T. Vishnyakova et al. Targeting of scavenger receptor class B type I by synthetic amphipathic alpha-helical- containing peptides blocks lipopolysaccharide (LPS) uptake and lps-induced pro-inflammatory cytokine responses in thp-1 monocyte cells J Biol Chem 279 34 2004 36072 36082
77. S. Thuahnai, S. Lund-Katz, and G. Anantharamaiah et al. A quantitative analysis of apolipoprotein binding to SR-BI: multiple binding sites for lipid-free and lipid-associated apolipoproteins J Lipid Res 44 6 2003 1132 1142
78. E. Reaven, S. Leers-Sucheta, and A. Nomoto et al. Expression of scavenger receptor class B type 1 (SR-BI) promotes microvillar channel formation and selective cholesteryl ester transport in a heterologous reconstituted system Proc Natl Acad Sci U S A 98 2001 1613
79. D. Williams, J. Wong, and R. Hamilton SR-BI is required for microvillar channel formation and the localization of HDL particles to the surface of adrenocortical cells in vivo J Lipid Res 43 2002 544
80. Y. Peng, W. Akmentin, and M. Connelly et al. Scavenger receptor BI (SR-BI) clustered on microvillar extensions suggests that this plasma membrane domain is a way station for cholesterol trafficking between cells and high-density lipoprotein Mol Biol Cell 15 2004 384 396
81. J. Hu, Z. Zhang, and W. Shen et al. Differential roles of cysteine residues in the cellular trafficking, dimerization, and function of the high-density lipoprotein receptor, SR-BI Biochemistry 50 50 2011 10860 10875
82. M. Donowitz, B. Cha, and N. Zachos et al. Nherf family and nhe3 regulation J Physiol 567 2005 3 11
83. A. Claperon, M. Mergey, and L. Fouassier Roles of the scaffolding proteins nherf in liver biology Clin Res Hepatol Gastroenterol 35 3 2011 176 181
84. D.L. Silver SR-BI and protein-protein interactions in hepatic high density lipoprotein metabolism Rev Endocr Metab Disord 5 4 2004 327 333
85. O. Kocher, and M. Krieger Role of the adaptor protein pdzk1 in controlling the HDL receptor SR-BI Curr Opin Lipidol 20 3 2009 236 241
86. R. Cunningham, R. Biswas, and D. Steplock et al. Role of nherf and scaffolding proteins in proximal tubule transport Urol Res 38 4 2010 257 262
87. K. Tsukamoto, T. Wales, and K. Daniels et al. Noncanonical role of the pdz4 domain of the adaptor protein pdzk1 in the regulation of the hepatic high density lipoprotein receptor scavenger receptor class B, type I (SR-BI) J Biol Chem 288 2013 19845 19860
88. M. Ikemoto, H. Arai, and D. Feng et al. Identification of a pdz-domain-containing protein that interacts with the scavenger receptor class B type I Proc Natl Acad Sci U S A 97 2000 6538 6543
89. O. Kocher, A. Yesilaltay, and C. Cirovic et al. Targeted disruption of the pdzk1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism J Biol Chem 278 2003 52820 52825
90. S. Fenske, A. Yesilaltay, and R. Pal et al. Overexpression of the pdz1 domain of pdzk1 blocks the activity of hepatic scavenger receptor, class B, type I by altering its abundance and cellular localization J Biol Chem 283 2008 22097 22104
91. S. Fenske, A. Yesilaltay, and R. Pal et al. Normal hepatic cell surface localization of the high density lipoprotein receptor, scavenger receptor class B, type I, depends on all four pdz domains of pdzk1 J Biol Chem 284 2009 5797 5806
92. O. Kocher, G. Birrane, and A. Yesilaltay et al. Identification of the pdz3 domain of the adaptor protein pdzk1 as a second, physiologically functional binding site for the c terminus of high density lipoprotein receptor scavenger receptor class B type I J Biol Chem 286 2011 25171 25186
93. O. Kocher, A. Yesilalttay, and C.-H. Shen et al. Influence of pdzk1 on lipoprotein metabolism and atherosclerosis Biochim Biophys Acta 1782 2008 310 316
94. W. Zhu, S. Saddar, and D. Seetharam et al. The scavenger receptor class B type I adaptor protein pdzk1 maintains endothelial monolayer integrity Circ Res 102 2008 480 487
95. D. Silver, N. Wang, and S. Vogel Identification of small pdzk1-associated protein, dd96/map17, as a regulator of pdzk1 and plasma high density lipoprotein levels J Biol Chem 278 2003 28528 28532
96. A. Rigotti, B. Trigatti, and M. Penman et al. A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism Proc Natl Acad Sci U S A 94 1997 12610 12615
97. Z. Hu, J. Hu, and Z. Zhang et al. Regulation of expression and function of scavenger receptor class B, type I (SR-BI) by na +/h + exchanger regulatory factors (nherfs) J Biol Chem 288 16 2013 11416 11435
98. U. Seidler, A. Singh, and A. Cinar et al. The role of the nherf family of pdz scaffolding proteins in the regulation of salt and water transport Ann N Y Acad Sci 1165 2009 249 260
99. J. Ardura, and P. Friedman Regulation of g protein-coupled receptor function by na +/h + exchange regulatory factors Pharmacol Rev 63 4 2011 882 900
100. A. Bretscher, K. Edwards, and R. Fehon Erm proteins and merlin: integrators at the cell cortex Nat Rev Mol Cell Biol 3 8 2002 586 599
101. M. de La Llera-Moya, G. Rothblat, and M. Conelly et al. Scavenger receptor BI (SR-BI) mediates free cholesterol flux independently of HDL tethering to the cell surface J Lipid Res 40 1999 575 580
102. M. de La Llera-Moya, M. Connelly, and D. Drazul et al. Scavenger receptor class B type I affects cholesterol homeostasis by magnifying cholesterol flux between cells and HDL J Lipid Res 42 2001 1969-078
103. B. Engelman, and M. Weidmann Cellular phospholipid uptake: flexible paths to coregulate the functions of intracellular lipids Biochim Biophys Acta 2010 1801 609 616
104. A. Kent, and I. Stylianou Scavenger receptor class B member I protein: hepatic regulation and its effects on lipids, reverse cholesterol transport, and atherosclerosis Hepat Med 3 2011 29 44
105. B. Trigatti, M. Krieger, and A. Rigotti Influence of the HDL receptor SR-BI on lipoprotein metabolism and atherosclerosis Arterioscler Thromb Vasc Biol 23 2003 1732 1738
106. C. Mineo, and P. Shaul Functions of scavenger receptor class B, type I in atherosclerosis Curr Opin Lipidol 23 2012 487 493
107. K. Murao, V. Terpdtra, and S. Green et al. Characterization of cla-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes J Biol Chem 272 1997 17551 17557
108. A. Shiratsuchi, Y. Kawasaki, and M. Ikemoto et al. Role of class B scavenger receptor type I in phagocytosis of apoptotic rat spermatogenic cells by sertoli cells J Biol Chem 274 1999 5901 5908
109. B. Fuhrman, A. Gantman, and M. Aviram Paraoxonase 1 (pon1) deficiency in mice is associated with esduced expression of macrophage SR-BI and consequently the loss of HDL cytoprotection against apoptosis Atherosclerosis 211 2010 61 68
110. T. Nishiuchi, K. Murao, and H. Imachi et al. Scavenger receptor class BI mediates the anti-apoptotic effect of erythropoietin Ann Med 42 2010 151 160
111. J.-R. Nofer, and M. van Eck Hdl scavenger receptor class B type I and platelet function Curr Opin Lipidol 22 2011 277 282
112. Z. Zheng, J. Ai, and X.A. Li Scavenger receptor class B type I and immune dysfunctions Curr Opin Endocrinol Diabetes Obes 21 2 2014 121 128
113. M. Catanese, R. Graziani, and T. von Hahn et al. High-avidity monoclonal antibodies against the human scavenger class B type I receptor efficiently block hepatitis c virus infection in the presence of high-density lipoprotein J Virol 81 2007 8063 8071
114. J. Grove, T. Huby, and Z. Stamataki et al. Scavenger receptor BI and BII expression levels modulate hepatitis c virus infectivity J Virol 81 2007 3162 3169
115. A. Syder, H. Lee, and M. Zeisel et al. Small molecule scavenger receptor BI antagonists are potent HCV entry inhibitors J Hepatol 54 2011 48 55
116. Y. Li, C. Kakinami, and Q. Li et al. Human apolipoprotein A-I is associated with dengue virus and enhances virus infection through SR-BI PLoS ONE 8 2013 e70390
117. C.D. Rodrigues, M. Hannus, and M. Prudencio et al. Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection Cell Host Microbe 4 3 2008 271 282
118. M. Vergeer, S. Korporaal, and R. Franssen et al. Genetic variant of the scavenger receptor BI in humans N Engl J Med 364 2011 136 145
119. L. Brunham, I. Tietjen, and A. Bochem et al. Novel mutations in scavenger receptor BI associated with high HDL cholesterol in humans Clin Genet 79 2011 575 581
120. T. Arai, N. Wang, and M. Benzouevski et al. Decreased atherosclerosis in heterozygous low density lipoprotein-deficient mice expressing the scavenger receptor BI transgene J Biol Chem 274 1999 2366-271
121. Y. Ueda, E. Gong, and L. Royer et al. Relationship between expression levels and atherogenesis in scavenger receptor class B, type I transgenics J Biol Chem 275 2000 20368 20373
122. K. Kozarsky, M. Donahee, and J. Glick et al. Gene transfer and hepatic overexpression of the HDL receptor SR-BI reduces atherosclerosis in the cholesterol-fed ldl receptor-deficient mouse Arterioscler Thromb Vasc Biol 20 2000 721 727
123. B. Trigatti, H. Rayburn, and M. Viñals et al. Influence of the HDL receptor SR-BI on reproductive and cardiovascular pathophysiology Proc Natl Acad Sci U S A 96 1999 9322 9327
124. S.D. Covey, M. Krieger, and W. Wang et al. Scavenger receptor class B type I-mediated protection against atherosclerosis in ldl receptor-negative mice involves its expression in bone marrow-derived cells Arterioscler Thromb Vasc Biol 23 9 2003 1589 1594
125. A. Braun, B.L. Trigatti, and M.J. Post et al. Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein e-deficient mice Circ Res 90 3 2002 270 276
126. H. Yu, W. Zhang, and P. Yancey et al. Macrophage apolipoprotein e reduces atherosclerosis and prevents premature death in apolipoprotein e and scavenger receptor-class BI double-knockout mice Arterioscler Thromb Vasc Biol 26 1 2006 150 156
127. D. Huszar, M. Varban, and F. Rinninger et al. Increased ldl cholesterol and atherosclerosis in ldl receptor-deficient mice with attenuated expression scavenger receptor BI Arterioscler Thromb Vasc Biol 20 2000 1068 1073
128. M. Van Eck, J. Twisk, and M. Hoekstra et al. Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver J Biol Chem 278 26 2003 23699 23705
129. T. Huby, C. Doucet, and C. Dachet et al. Knockdown expression and hepatic deficiency reveal an atheroprotective role for SR-BI in liver and peripheral tissues J Clin Invest 116 2006 2787-76
130. H. Imachi, K. Murao, and W. Cao et al. Expression of human scavenger receptor b1 on and in human platelets Arterioscler Thromb Vasc Biol 23 5 2003 898 904
131. V.S. Dole, J. Matuskova, and E. Vasile et al. Thrombocytopenia and platelet abnormalities in high-density lipoprotein receptor-deficient mice Arterioscler Thromb Vasc Biol 28 6 2008 1111 1116
132. S. Korporaal, I. Meurs, and A. Hauer et al. Deletion of the high-density lipoprotein receptor scavenger receptor BI in mice modulates thrombosis susceptibility and indirectly affects platelet function by elevation of plasma free cholesterol Arterioscler Thromb Vasc Biol 31 2011 34 42
133. T.M. Teslovich, K. Musunuru, and A.V. Smith et al. Biological, clinical and population relevance of 95 loci for blood lipids Nature 466 7307 2010 707 713