Role of the adaptor protein PDZK1 in controlling the HDL receptor SR-BI

Current Opinion in Lipidology

Volumn 20, Issue 3, 2009, Pages 236-241

  Kocher, Olivier ^a   Krieger, Monty ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Atherosclerosis; Endothelium; High density lipoprotein receptor; PDZ domains

Indexed keywords

2 [4 [2 [3 CYCLOHEXYL 1 (4 CYCLOHEXYLBUTYL)UREIDO]ETHYL]PHENYLTHIO] 2 METHYLPROPIONIC ACID; ADAPTOR PROTEIN; CIPROFIBRATE; FENOFIBRATE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; PDZ PROTEIN; PROTEIN PDZK1; SCAVENGER RECEPTOR BI; UNCLASSIFIED DRUG;

ATHEROGENIC DIET; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CORONARY ARTERY ATHEROSCLEROSIS; DIMERIZATION; GENE CONTROL; GENE INACTIVATION; HEART INFARCTION; HORMONAL REGULATION; HUMAN; ISCHEMIC HEART DISEASE; LIPOPROTEIN METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, CD36; ATHEROSCLEROSIS; CHOLESTEROL, HDL; ENDOTHELIAL CELLS; HUMANS; LIVER;

EID: 67049143906     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOL.0b013e32832aee82     Document Type: Review

References (65)

1. Gordon T, Castelli W, Hjortland M, et al. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med 1977; 62:707-714.
2. Miller G, Miller N. Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. Lancet 1975; 1:16-19.
3. Glomset J. The plasma lecithinrcholesterol acyltrans ferase reaction. J Lipid Res 1968; 9:155-167.
4. Krieger M. Charting the fate of the "Good Cholesterol": identification and characterization of the high-density lipoprotein receptor SR-BI. Annu Rev Biochem 1999; 68:523-558.
5. Krieger M, Kozarsky K. Influence of the HDL receptor SR-BI on atherosclerosis. Curr Opin Lipidol 1999; 10:491-497.
6. Rigotti A, Miettinen H, Krieger M. The rale of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues. Endocrine Rev 2003; 24:357-387.
7. Cohen J, Kimmel M, Polanski A, Hobbs H. Molecular mechanisms of auto-somal recessive hypercholesterolemia. Curr Opin Lipidol 2003; 14:121-127.
8. Stolt P, Bock H. Modulation of lipoprotein receptor functions by intracellular adaptor proteins. Cell Signal 2006; 18:1560-1571.
9. He G, Gupta S, Yi M, et al. ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin and AP-2. J Biol Chem 2002; 277:44044-44049.
10. Michaely P, Li W, Anderson R, et al. The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits. J Biol Chem 2004; 279:34023-34031.
11. Zuliani G, Arca M, Signore A, et al. Characterization of a new form of inherited hypercholesterolemia: familial recessive hypercholesterolemia. Arterioscler Thromb Vase Biol 1999; 19:802-809.
12. Acton S, Rigotti A, Landschulz KT, et al. Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science 1996; 271:518-520.
13. Ikemoto M, Arai H, Feng D, et al. Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I. Proc Natl Acad Sci U S A 2000; 97:6538-6543.
14. Kocher O, Yesilaltay A, Cirovic C, et al. Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism. J Biol Chem 2003; 278:52820-52825.
15. Seidler U, Singh A, Chen M, et al. Knockout mouse models for intestinal electrolyte transporters and regulatory PDZ adaptors: new insights into cystic fibrosis, secretory diarrhoea and fructose-induced hypertension. Exp Physiol 2009; 94:175-179.
16. Yesilaltay A, Kocher O, Rigotti A, Krieger M. Regulation of SR-BI-mediated high-density lipoprotein metabolism by the tissue-specific adaptor protein PDZK1. Curr Opin Lipidol 2005; 16:147-152.
17. Ji Y, Jian B, Wang N, et al. Scavenger receptor Bl promotes high density lipoprotein-mediated cellular cholesterol efflux. J Biol Chem 1997; 272: 20982-20985.
18. Rigotti A, Trigatti BL, Penman M, et al. A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism. Proc Natl Acad Sci U S A 1997; 94:12610-12615.
19. Braun A, Zhang S, Miettinen H, et al. Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor SR-B1/apolipopro-tein E double knockout mouse. Proc Natl Acad Sci U S A 2003; 100:7283-7288.
20. Mardones P, Quinones V, Amigo L, et al. Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type l-deficient mice. J Lipid Res 2001; 42:170-180.
21. Braun A, Trigatti BL, Post MJ, et al. Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice. Circ Res 2002; 90:270-276.
22. Trigatti B, Rayburn H, Vinals M, et al. Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology. Proc Natl Acad Sci U S A 1999; 96:9322-9327.
23. Van Eck M, Twisk J, Hoekstra M, et al. Differential effects of scavenger receptor Bl deficiency on lipid metabolism in cells of the arterial wall and in the liver. J Biol Chem 2003; 278:23699-23705.
24. Arai T, Wang N, Bezouevski M, et al. Decreased atherosclerosis in heterozygous low density lipoprotein receptor-deficient mice expressing the scaveger receptor Bl transgene. J Biol Chem 1999; 274:2266-2271.
25. Kozarsky K, Donahee M, Glick J, et al. Gene transfer and hepatic over-expression of the HDL receptor SR-BI reduces atherosclerosis in the cholesterol-fed LDL receptor-deficient mouse. Arterioscler Thromb Vasc Biol 2000; 20:721-727.
26. Ueda Y, Gong E, Royer L, et al. Relationship between expression levels and atherogenesis in scavenger receptor class B, type I transgenics. J Biol Chem 2000; 275:20368-20373.
27. Zhang Y, Da Silva J, Reilly M, et al. Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo. J Clin Invest 2005; 115:2870-2874.
28. Rader D, Alexander E, Weibel G, el al. Role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis. J Lipid Res 2008 (in press).
29. Fenske S, Yesilaltay A, Pal R, et al. Normal hepatic cell-surface localization of the high-density lipoprotein receptor, SR-BI, depends on all four PDZ domains of PDZK1. J Biol Chem 2009; 284:5797-5806. This study establishes that all four domains of PDZK1 are necessary for normal expression, localization and function of SR-BI in hepatocytes.
30. Kocher O, Cornelia N, Tognazzi K, Brown LF. Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains. Lab Invest 1998; 78:117-125.
31. Zhu W, Saddar S, Seetharam D, et al. The scavenger receptor class B type I adaptor protein PDZK1 maintains endothelial monolayer integrity. Circ Res 2008; 102:480-487. This study shows that PDZK1 is necessary for endothelial regeneration following injury.
32. Kocher O, Yesilaltay A, Shen C, et al. Influence of PDZK1 on lipoprotein metabolism and atherosclerosis. Biochim Biophys Acta 2008; 1782:310-316. This study establishes that PDZK1 is atheroprotective in mice.
33. Pawson T, Scott JD. Signaling through scaffold, anchoring, and adaptor proteins. Science 1997; 278:2075-2080.
34. Doyle DA, Lee A, Lewis J, et al. Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell 1996; 85:1067-1076.
35. Tonikian R, Zhang Y, Sazinsky S, et al. A specificity map for the PDZ domain family. PLoS Biol 2008; 6:e239.
36. Hung A, Sheng M. PDZ domains: structural modules for protein complex assembly. J Biol Chem 2002; 277:5699-5702.
37. Nourry C, Grant s, Borg J. PDZ domain proteins: plug and play! Sci STKE 2003; 2003:RE7.
38. Chen J, Chang B, Allen J, et al. Predicting PDZ domain-peptide interactions from primary sequences. Nat Biotechnol 2008; 26:1041-1045.
39. Stiffler M, Chen J, Grantcharova V, et al. PDZ domain binding selectivity is optimized across the mouse proteome. Science 2007; 317:364-369.
40. Wang P, Wang J, Xiao Y, et al. Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface. J Biol Chem 2005; 280:30143-30149.
41. Hillesheim J, Riederer B, Tuo B, et al. Down regulation of small intestinal ion transport in PDZK1 (CAP70/NHERF3) deficient mice. Pflugers Archiv Eur J Physiol 2007; 454:575-586.
42. Thomson R, Wang T, Thomson B, et al. Role of PDZK1 in membrane expression of renal brush border ion exchangers. Proc Natl Acad Sci U S A 2005; 102:13331-13336.
43. Kocher O, Pal R, Roberts M, et al. Targeted disruption of the PDZK1 gene by homologous recombination. Mol Cell Biol 2003; 23:1175-1180.
44. Yesilaltay A, Kocher O, Pal R, et al. PDZK1 is required for maintaining hepatic scavenger receptor, class B, type I (SR-BI) steady state levels but not its surface localization or function. J Biol Chem 2006; 281:28975-28980.
45. Komori H, Arai H, Kashima T, et al. Co-expression of CLA-1 and human PDZK1 in murine liver modulates HDL cholesterol metabolism. Arterioscler Thromb Vase Biol 2008; 28:1298-1303.
46. Fenske S, Yesilaltay A, Pal R, et al. Overexpression of the PDZ1 domain of PDZK1 blocks the activity of hepatic scavenger receptor, class B, type I by altering its abundance and cellular localization. J Biol Chem 2008; 283:22097-22104. This study shows that the first PDZ domain of PDZK1 expressed as a truncated mutant functions as a dominant negative.
47. Lalonde D, Bretscher A. The scaffold protein PDZK1 undergoes a head-to-tail intramolecular association that negatively regulates its interaction with EBP50. Biochemistry 2009. [Epub ahead of print]
48. Niemeier A, Kovacs W, Strobl W, Stangl H. Atherogenic diet leads to posttranslational down-regulation of murine hepatocyte SR-BI expression. Atherosclerosis 2009; 202:169-175.
49. Robichaud J, Francis G, Vance D. A role for hepatic scavenger receptor class B, type I in decreasing high density lipoprotein levels in mice that lack phosphatidylethanolamine N-methyltransferase. J Biol Chem 2008; 283:35496-35506.
50. Nakamura T, Shibata N, Nishimoto-Shibata T, et al. Regulation of SR-BI protein levels by phosphorylation of its associated protein, PDZK1. Proc Natl Acad Sci U S A 2005; 102:13404-13409.
51. Mardones P, Pilon A, Bouly M, et al. Fibrate down-regulate hepatic scavenger receptor class B type I protein expression in mice. J Biol Chem 2003; 278:7884-7890.
52. Lan D, Silver DL. Fenofibrate induces a novel degradation pathway for scavenger receptor B-l independent of PDZK1. J Biol Chem 2005; 280:23390-23396.
53. Tachibana K, Anzai N, Ueda C, et al. Regulation of the human PDZK1 expression by peroxisome proliferator-activated receptor alpha. FEBS Lett 2008; 582:3884-3888.
54. Walker G, MacLeod K, Williams A, et al. Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer. Gynecol Oncol 2007; 106:461-468.
55. Rader D, Dugi K. The endothelium and lipoproteins: insights from recent cell biology and animal studies. Semin Thromb Hemost 2000; 26:521-528.
56. Nofer J, Kehrel B, Fobker M, er a/. HDL and atherosclerosis: beyond reverse cholesterol transport. Atherosclerosis 2002; 161:1-16.
57. Hatzopoulos A, Rigotti A, Rosenberg R, Krieger M. Temporal and spatial pattern of expression of the HDL receptor SR-BI during murine embryogen-esis. J Lipid Res 1998; 39:495-508.
58. Yuhanna I, Zhu Y, Cox B, et al. High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase. Nat Med 2001; 7:853-857.
59. Li X, Titlow W, Jackson B, et al. High density lipoprotein binding to scavenger receptor, Class B, type I activates endothelial nitric-oxide synthase in a ceramide-dependent manner. J Biol Chem 2002; 277: 11058-11063.
60. Mineo C, Deguchi H, Griffin J, Shaul PW. Endothelial and antithrombotic actions of HDL. Circ Res 2006; 98:1352-1364.
61. Mineo C, Shaul P. Role of high-density lipoprotein and scavenger receptor B type I in the promotion of endothelial repair. Trends Cardiovasc Med 2007; 17:156-161.
62. Kimura T, Tomura H, Mogi C, et al. Role of scavenger receptor class B type I and sphingosine 1-phosphate receptors in high density lipoprotein-induced inhibition of adhesion molecule expression in endothelial cells. J Biol Chem 2006; 281:37457-37467.
63. Assanasen C, Mineo C, Seetharam D, et al. Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor-BI mediate HDL-initiated signaling. J Clin Invest 2005; 115:969-977.
64. Seetharam D, Yuhanna I, Marcel Y, et al. Cholesterol binding, efflux, and a PDZ-interaoting domain of scavenger receptor-BI mediate HDL-initiated signaling. Circ Res 2006; 98:63-72.
65. Covey S, Krieger M, Wang W, et al. Scavenger receptor class B type l-mediated protection against atherosclerosis in LDL receptor-negative mice involves its expression in bone marrow-derived cells. Arterioscler Thromb Vasc Biol 2003; 23:1589-1594.