Knockdown expression and hepatic deficiency reveal an atheroprotective role for SR-BI in liver and peripheral tissues

Journal of Clinical Investigation

Volumn 116, Issue 10, 2006, Pages 2767-2776

  Huby, Thierry ^a,d   Doucet, Chantal ^a   Dachet, Christiane ^a   Ouzilleau, Betty ^a   Ueda, Yukihiko ^b   Afzal, Veena ^c   Rubin, Edward ^c   Chapman, M John ^a   Lesnik, Philippe ^a  

^a SORBONNE UNIVERSITÉ   (France)

^b KYOTO UNIVERSITY   (Japan)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

LIPID; SCAVENGER RECEPTOR BI; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROGENIC DIET; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; GENE INACTIVATION; HYPERCHOLESTEROLEMIA; KNOCKOUT MOUSE; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; LIVER CELL; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL;

ALLELES; ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; APOLIPOPROTEINS; ATHEROSCLEROSIS; ATP-BINDING CASSETTE TRANSPORTERS; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CHOLESTEROL, VLDL; DIET, ATHEROGENIC; FEMALE; GENE EXPRESSION; INTERLEUKIN-6; LIPOPROTEINS; LIVER; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; SCAVENGER RECEPTORS, CLASS B; SEX FACTORS; TRIGLYCERIDES;

EID: 33749430965     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI26893     Document Type: Article

References (46)

1. Marsche, G., et al. 2001. Identification of the human analog of SR-BI and LOX-1 as receptors for hypochlorite-modified high density lipoprotein on human umbilical venous endothelial cells. FASEB J. 15:1095-1097.
2. Yuhanna, I.S., et al. 2001. High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase. Nat. Med. 7:853-857.
3. Yeh, Y.C., Hwang, G.Y., Liu, I.P., and Yang, V.C. 2002. Identification and expression of scavenger receptor SR-BI in endothelial cells and smooth muscle cells of rat aorta in vitro and in vivo. Atherosclerosis. 161:95-103.
4. Chinetti, G., et al. 2000. CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors. Circulation. 101:2411-2417.
5. Rhainds, D., and Brissette, L. 2004. The role of scavenger receptor class B type I (SR-BI) in lipid trafficking. Defining the rules for lipid traders. Int. J. Biochem. Cell Biol. 36:39-77.
6. Kozarsky, K.F., Donahee, M.H., Glick, J.M., Krieger, M., and Rader, D.J. 2000. Gene transfer and hepatic overexpression of the HDL receptor SR-BI reduces atherosclerosis in the cholesterol-fed LDL receptor-deficient mouse. Arterioscler. Thromb. Vasc. Biol. 20:721-727.
7. Ueda, Y., et al. 1999. Lower plasma levels and accelerated clearance of high density lipoprotein (HDL) and non-HDL cholesterol in scavenger receptor class B type I transgenic mice. J. Biol. Chem. 274:7165-7171.
8. Ji, Y., et al. 1999. Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile. J. Biol. Chem. 274:33398-33402.
9. Kozarsky, K.F., et al. 1997. Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels. Nature. 387:414-417.
10. Rigotti, A., et al. 1997. A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism. Proc. Natl. Acad. Sci. U. S. A. 94:12610-12615.
11. Varban, M.L., et al. 1998. Targeted mutation reveals a central role for SR-BI in hepatic selective uptake of high density lipoprotein cholesterol. Proc. Natl. Acad. Sci. U. S. A. 95:4619-4624.
12. Osgood, D., et al. 2003. Genetic variation at the scavenger receptor class B type I gene locus determines plasma lipoprotein concentrations and particle size and interacts with type 2 diabetes: the Framingham study. J. Clin. Endocrinol. Metab. 88:2869-2879.
13. Hong, S.H., et al. 2002. Association between HaeIII polymorphism of scavenger receptor class B type I gene and plasma HDL-cholesterol concentration. Ann. Clin. Biochem. 39:478-481.
14. Acton, S., et al. 1999. Association of polymorphisms at the SR-BI gene locus with plasma lipid levels and body mass index in a white population. Arterioscler. Thromb. Vasc. Biol. 19:1734-1743.
15. Van Eck, M., et al. 2003. Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver. J. Biol. Chem. 278:23699-23705.
16. Trigatti, B., et al. 1999. Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology. Proc. Natl. Acad. Sci. U. S. A. 96:9322-9327.
17. Ueda, Y., et al. 2000. Relationship between expression levels and atherogenesis in scavenger receptor class B, type I transgenics. J. Biol. Chem. 275:20368-20373.
18. Arai, T., Wang, N., Bezouevski, M., Welch, C., and Tall, A.R. 1999. Decreased atherosclerosis in heterozygous low density lipoprotein receptor-deficient mice expressing the scavenger receptor BI transgene. J. Biol. Chem. 274:2366-2371.
19. Zhang, Y., et al. 2005. Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo. J. Clin. Invest. 115:2870-2874. doi:10.1172/JCI25327.
20. Li, X.A., et al. 2002. High density lipoprotein binding to scavenger receptor, class B, type I activates endothelial nitric-oxide synthase in a ceramide-dependent manner. J. Biol. Chem. 277:11058-11063.
21. Covey, S.D., Krieger, M., Wang, W., Penman, M., and Trigatti, B.L. 2003. Scavenger receptor class B type I-mediated protection against atherosclerosis in LDL receptor-negative mice involves its expression in bone marrow-derived cells. Arterioscler. Thromb. Vasc. Biol. 23:1589-1594.
22. Zhang, W., et al. 2003. Inactivation of macrophage scavenger receptor class B type I promotes atherosclerotic lesion development in apolipoprotein E-deficient mice. Circulation. 108:2258-2263.
23. Van Eck, M., Bos, I.S., Hildebrand, R.B., Van Rij, B.T., and Van Berkel, T.J. 2004. Dual role for scavenger receptor class B, type I on bone marrow-derived cells in atherosclerotic lesion development. Am. J. Pathol. 165:785-794.
24. Li, X.A., Guo, L., Dressman, J.L., Asmis, R., and Smart, E.J. 2005. A novel ligand-independent apoptotic pathway induced by scavenger receptor class B, type I and suppressed by endothelial nitric-oxide synthase and high density lipoprotein. J. Biol. Chem. 280:19087-19096.
25. Nakagawa, A., Shiratsuchi, A., Tsuda, K., and Nakanishi, Y. 2005. In vivo analysis of phagocytosis of apoptotic cells by testicular Sertoli cells. Mol. Reprod. Dev. 71:166-177.
26. Goti, D., et al. 2001. Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL-associated vitamin E. J. Neurochem. 76:498-508.
27. Mardones, P., et al. 2002. Alpha-tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-BI)-deficient mice. J. Nutr. 132:443-449.
28. Kocher, O., et al. 2003. Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism. J. Biol. Chem. 278:52820-52825.
29. Postic, C., and Magnuson, M.A. 2000. DNA excision in liver by an albumin-Cre transgene occurs progressively with age. Genesis. 26:149-150.
30. Timmins, J.M., et al. 2005. Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. J. Clin. Invest. 115:1333-1342. doi:10.1172/JCI200523915.
31. Miettinen, H.E., Rayburn, H., and Krieger, M. 2001. Abnormal lipoprotein metabolism and reversible female infertility in HDL receptor (SR-BI)-deficient mice. J. Clin. Invest. 108:1717-1722. doi:10.1172/JCI200113288.
32. Huszar, D., et al. 2000. Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1. Arterioscler. Thromb. Vasc. Biol. 20:1068-1073.
33. Brundert, M., et al. 2005. Scavenger receptor class B type I mediates the selective uptake of high-density lipoprotein-associated cholesteryl ester by the liver in mice. Arterioscler. Thromb. Vasc. Biol. 25:143-148.
34. Out, R., et al. 2004. Scavenger receptor class B type I is solely responsible for the selective uptake of cholesteryl esters from HDL by the liver and the adrenals in mice. J. Lipid Res. 45:2088-2095.
35. Wang, N., Arai, T., Ji, Y., Rinninger, F., and Tall, A.R. 1998. Liver-specific overexpression of scavenger receptor BI decreases levels of very low density lipoprotein ApoB, low density lipoprotein ApoB, and high density lipoprotein in transgenic mice. J. Biol. Chem. 273:32920-32926.
36. Out, R., et al. 2005. Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice. J. Lipid Res. 46:1172-1181.
37. Baranova, I.N., et al. 2005. Serum amyloid A binding to CLA-1 (CD36 and LIMPII analogous-1) mediates serum amyloid A protein-induced activation of ERK1/2 and p38 mitogen-activated protein kinases. J. Biol. Chem. 280:8031-8040.
38. O'Brien, K.D., et al. 2005. Serum amyloid A and lipoprotein retention in murine models of atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 25:785-790.
39. Terasawa, Y., et al. 2000. Increased atherosclerosis in hyperlipidemic mice deficient in alpha-tocopherol transfer protein and vitamin E. Proc. Natl. Acad. Sci. U. S. A. 97:13830-13834.
40. Sata, M., et al. 2002. Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis. Nat. Med. 8:403-409.
41. Gillotte-Taylor, K., Boullier, A., Witztum, J.L., Steinberg, D., and Quehenberger, O. 2001. Scavenger receptor class B type I as a receptor for oxidized low density lipoprotein. J. Lipid Res. 42:1474-1482.
42. Ji, Y., et al. 1997. Scavenger receptor BI promotes high density lipoprotein-mediated cellular cholesterol efflux. J. Biol. Chem. 272:20982-20985.
43. Li, Y., et al. 2005. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J. Biol. Chem. 280:21763-21772.
44. Folch, J., Lees, M., and Sloane Stanley, G.H. 1957. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226:497-509.
45. Treguier, M., et al. 2004. Transcription factor sterol regulatory element binding protein 2 regulates scavenger receptor Cla-1 gene expression. Arterioscler. Thromb. Vasc. Biol. 24:2358-2364.
46. -/- mice reveals a role for fractalkine in atherogenesis. J. Clin. Invest. 111:333-340. doi:10.1172/ JCI200315555.