Regulation of expression and function of scavenger receptor class B, type i (SR-BI) by Na+/H+ exchanger regulatory factors (NHERFs)

Journal of Biological Chemistry

Volumn 288, Issue 16, 2013, Pages 11416-11435

  Hu, Zhigang ^a,b   Hu, Jie ^a,b   Zhang, Zhonghua ^a,b   Shen, Wen Jun ^a,b   Yun, C Chris ^c   Berlot, Catherine H ^d   Kraemer, Fredric B ^a,b   Azhar, Salman ^a,b  

^a VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^b STANFORD UNIVERSITY   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d WEIS CENTER FOR RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLASS B; PRODUCT FORMATION; PROTEIN DOMAINS; PROTEIN LEVEL; REGULATORY FACTORS; SCAVENGER RECEPTOR;

BIOCHEMISTRY; BIOLOGY;

PROTEINS;

CHOLESTEROL ESTER; CYCLIC AMP; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN; MERM PROTEIN; MESSENGER RNA; PDZ PROTEIN; PROTEIN; SCAVENGER RECEPTOR BI; SODIUM PROTON EXCHANGE PROTEIN 1; SODIUM PROTON EXCHANGE PROTEIN 2; SODIUM PROTON EXCHANGE PROTEIN 3; SODIUM PROTON EXCHANGE PROTEIN 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GRANULOSA CELL; IMMUNOPRECIPITATION; MALE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; RAT; RECEPTOR BINDING; STEROIDOGENESIS;

AMINO ACID MOTIFS; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CERCOPITHECUS AETHIOPS; CHO CELLS; CHOLESTEROL ESTERS; COS CELLS; CRICETINAE; CRICETULUS; DOWN-REGULATION; FEMALE; GRANULOSA CELLS; MALE; PHOSPHOPROTEINS; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SCAVENGER RECEPTORS, CLASS B; SODIUM-HYDROGEN ANTIPORTER;

EID: 84876536517     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.437368     Document Type: Article

References (87)

1. Gwynne, J. T., and Hess, B. (1980) The role of high density lipoproteins in rat adrenal cholesterol metabolism and steroidogenesis. J. Biol. Chem. 255, 10875-10883.
2. Glass, C., Pittman, R. C., Weinstein, D. B., and Steinberg, D. (1983) Dissociation of tissue uptake of cholesterol ester from that of apoprotein A-I of rat plasma high density lipoprotein. Selective delivery of cholesteryl ester to liver, adrenal, and gonad. Proc. Natl. Acad. Sci. U.S.A. 80, 5435-5439.
3. Reaven, E., Chen, Y. D., Spicher, M., and Azhar, S. (1984) Morphological evidence that high density lipoproteins are not internalized by steroid producing cells during in situ organ perfusion. J. Clin. Invest. 74, 1384-1397.
4. Pittman, R. C., Knecht, T. P., Rosenbaum, M. S., and Taylor, C. A., Jr. (1987)A nonendocytic mechanism for the selective uptake of high density lipoprotein-associated cholesteryl esters. J. Biol. Chem. 262, 2443-2450.
5. Azhar, S., Stewart, D., and Reaven, E. (1989) Utilization of cholesterol-rich lipoproteins by perfused rat adrenals. J. Lipid Res. 30, 1799-1810.
6. Azhar, S., and Reaven, E. (2002) Scavenger receptor class BI and selective cholesteryl ester uptake. Partners in the regulation of steroidogenesis. Mol. Cell Endocrinol. 195, 1-26.
7. Azhar, S., Leers-Sucheta, S., and Reaven, E. (2003) Cholesterol uptake in adrenal and gonadal tissues. The SR-BI and "selective" pathway connection. Front. Biosci. 8, s998-1029.
8. Temel, R. E., Trigatti, B., DeMattos, R. B., Azhar, S., Krieger, M., and Williams, D. L. (1997) Scavenger receptor class B, type I (SR-BI) is the major route for the delivery of high density lipoprotein cholesterol to the steroidogenic pathway in cultured mouse adrenocortical cells. Proc. Natl. Acad. Sci. U.S.A. 94, 13600-13605.
9. Cherradi, N., Bideau, M., Arnaudeau, S., Demaurex, N., James, R. W., Azhar, S., and Capponi, A. M. (2001) Angiotensin II promotes selective uptake of high density lipoprotein cholesterol esters in bovine adrenal glomerulosa and human adrenocortical carcinoma cells through induction of scavenger receptor class B type I. Endocrinology 142, 4540-4549.
10. Azhar, S., Tsai, L., Medicherla, S., Chandrasekher, Y., Giudice, L., and Reaven, E. (1998) Human granulosa cells use high density lipoprotein cholesterol for steroidogenesis. J. Clin. Endocrinol. Metab. 83, 983-991.
11. Reaven, E., Tsai, L., and Azhar, S. (1995) Cholesterol uptake by the "selective" pathway of ovarian granulosa cells. Early intracellular events. J. Lipid Res. 36, 1602-1617.
12. Reaven, E., Lua, Y., Nomoto, A., Temel, R., Williams, D. L., van der Westhuyzen, D. R., and Azhar, S. (1999) The selective pathway and a highdensity lipoprotein receptor (SR-BI) in ovarian granulosa cells of the mouse. Biochim. Biophys. Acta 1436, 565-576.
13. Towns, R., Azhar, S., Peegel, H., and Menon, K. M. (2005) LH/hCG-stimulated androgen production and selective HDL-cholesterol transport are inhibited by a dominant-negative CREB construct in primary cultures of rat theca-interstitial cells. Endocrine 27, 269-277.
14. Reaven, E., Zhan, L., Nomoto, A., Leers-Sucheta, S., and Azhar, S. (2000) Expression and microvillar localization of scavenger receptor class B, type I (SR-BI) and selective cholesteryl ester uptake in Leydig cells from rat testis. J. Lipid Res. 41, 343-356.
15. Hu, J., Zhang, Z., Shen, W.-J., and Azhar, S. (2010) Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones. Nutr. Metab. 7, 47.
16. Rinninger, F., Brundert, M., Jäckle, S., Galle, P. R., Busch, C., Izbicki, J. R., Rogiers, X., Henne-Bruns, D., Kremer, B., Broelsch, C. E., and Greten, H. (1994) Selective uptake of high-density lipoprotein-associated cholesteryl esters by human hepatocytes in primary culture. Hepatology 19, 1100-1114.
17. Kozarsky, K. F., Donahee, M. H., Rigotti, A., Iqbal, S. N., Edelman, E. R., and Krieger, M. (1997) Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels. Nature 387, 414-417.
18. Ji, Y., Wang, N., Ramakrishnan, R., Sehayek, E., Huszar, D., Breslow, J. L., and Tall, A. R. (1999) Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile. J. Biol. Chem. 274, 33398-33402.
19. Mardones, P., Quiñones, V., Amigo, L., Moreno, M., Miquel, J. F., Schwarz, M., Miettinen, H. E., Trigatti, B., Krieger, M., VanPatten, S., Cohen, D. E., and Rigotti, A. (2001) Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice. J. Lipid Res. 42, 170-180.
20. Van Eck, M., Twisk J., Hoekstra, M., Van Rij, B. T., Van der Lans, C. A., Bos, I. S., Kruijt, J. K., Kuipers, F., and Van Berkel, T. J. (2003) Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver. J. Biol. Chem. 278, 23699-23705.
21. Acton, S., Rigotti, A., Landschulz, K. T., Xu, S., Hobbs, H. H., and Krieger, M. (1996) Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science 271, 518-520.
22. Rigotti, A., Miettinen, H. E., and Krieger, M. (2003) The role of the highdensity lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues. Endocr. Rev. 24, 357-387.
23. Gu, X., Trigatti, B., Xu, S., Acton, S., Babitt, J., and Krieger, M. (1998) The efficient cellular uptake of high density lipoprotein lipids via scavenger receptor class B type I requires not only receptor-mediated surface binding but also receptor-specific lipid transfer mediated by its extracellular domain. J. Biol. Chem. 273, 26338-26348.
24. Connelly, M. A., Klein, S. M., Azhar, S., Abumrad, N. A., and Williams, D. L. (1999) Comparison of class B scavenger receptors, CD36 and scavenger receptors mediate high density lipoprotein-cholesteryl ester selective uptake but SR-BI exhibits a unique enhancement of cholesteryl ester uptake. J. Biol. Chem. 274, 41-47.
25. Viñals, M., Xu, S., Vasile, E., and Krieger, M. (2003) Identification of the N-linked glycosylation sites on the high density lipoprotein (HDL) receptor SR-BI and assessment of their effects on HDL binding and selective lipid uptake. J. Biol. Chem. 278, 5325-5332.
26. Hu, J., Zhang, Z., Shen, W.-J., Nomoto, A., and Azhar, S. (2011) Differential roles of cysteine residues in the cellular trafficking, dimerization, and function of the high-density lipoprotein receptor, SR-BI. Biochemistry 50, 10860-10875.
27. Landschulz, K. T., Pathak, R. K., Rigotti, A., Krieger, M., and Hobbs, H. H. (1996) Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat. J. Clin. Invest. 98, 984-995.
28. Rigotti, A., Edelman, E. R., Seifert, P., Iqbal, S. N., DeMattos, R. B., Temel, R. E., Krieger, M., and Williams, D. L. (1996) Regulation by adrenocorticotropic hormone of the in vivo expression of scavenger receptor, in steroidogenic cells of the murine adrenal gland. J. Biol. Chem. 271, 33545-33549.
29. Reaven, E., Nomoto, A., Leers-Sucheta, S., Temel, R., Williams, D. L., and Azhar, S. (1998) Expression and microvillar localization of scavenger receptor, class B, type I (a high density lipoprotein receptor) in luteinized and hormone-desensitized rat ovarian models. Endocrinology 139, 2847-2856.
30. Azhar, S., Nomoto, A., and Reaven, E. (2002) Hormonal regulation of adrenal microvillar channel formation. J. Lipid Res. 43, 861-871.
31. Azhar, S., Nomoto, A., Leers-Sucheta, S., and Reaven, E. (1998) Simultaneous induction of an HDL receptor protein (SR-BI) and the selective uptake of HDL-cholesteryl esters in a physiologically relevant steroidogenic model. J. Lipid Res. 39, 1616-1628.
32. Ikemoto, M., Arai, H., Feng, D., Tanaka, K., Aoki, J., Dohmae, N., Takio, K., Adachi, H., Tsujimoto, M., and Inoue, K. (2000) Identification of a PDZdomain-containing protein that interacts with scavenger receptor class B type I. Proc. Natl. Acad. Sci. U.S.A. 97, 6538-6543.
33. Leiva, A., Verdejo, H., Benítez, M. L., and Martínez, A. (2011) Mechanisms regulating hepatic SR-BI expression and their impact on HDL metabolism. Atherosclerosis 217, 299-307.
34. Kocher, O., Yesilaltay, A., Cirovic, C., Pal, R., Rigotti, A., and Krieger, M. (2003) Targeted disruption of the PDZK1 gene in mice causes tissuespecific deletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism. J. Biol. Chem. 278, 52820-52825.
35. Fenske, S. A., Yesilaltay, A., Pal, R., Daniels, K., Rigotti, A., Krieger, M., and Kocher, O. (2008) Overexpression of the PDZ1 domain of PDZK1 blocks the activity of hepatic scavenger receptor, class B, type I by altering its abundance and cellular localization. J. Biol. Chem. 283, 22097-22104.
36. Fenske, S. A., Yesilaltay, A., Pal, R., Daniels, K., Barker, C., Quiñones, V., Rigotti, A., Krieger, M., and Kocher, O. (2009) Normal hepatic cell surface localization of the high density lipoprotein receptor, scavenger receptor class B, type I, depends on all four PDZ domains of PDZK1. J. Biol. Chem. 284, 5797-5806.
37. Wang, S., Yue, H., Derin, R. B., Guggino, W. B., and Li, M. (2000) Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity. Cell 103, 169-179.
38. Anzai, N., Miyazaki, H., Noshiro, R., Khamdang, S., Chairoungdua, A., Shin, H.-J., Enomoto, A., Sakamoto, S., Hirata, T., Tomita, K., Kanai, Y., and Endou, H. (2004) The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus. J. Biol. Chem. 279, 45942-45950.
39. Hu, Z., Shen, W.-J., Kraemer, F. B., and Azhar, S. (2012) MicroRNAs-125a and -455 repress lipoprotein-supported steroidogenesis by targeting scavenger receptor class B, type I (SR-BI) in steroidogenic cells. Mol. Cell. Biol. 32, 5035-5045.
40. Donowitz, M., Cha, B., Zachos, N. C., Brett, C. L., Sharma, A., Tse, C. M., and Li, X. (2005) NHERF family and NHE3 regulation. J. Physiol. 567, 3-11.
41. Seidler, U., Singh, A. K., Cinar, A., Chen, M., Hillesheim, J., Hogema, B., and Riederer, B. (2009) The role of the NHERF family of PDZ scaffolding proteins in the regulation of salt and water transport. Ann. N.Y. Acad. Sci. 1165, 249-260.
42. Ardura, J. A., and Friedman, P. A. (2011) Regulation of G protein-coupled receptor function by Na+/H+ exchange regulatory factors. Pharmacol. Rev. 63, 882-900.
43. Bretscher, A., Edwards, K., and Fehon, R. G. (2002) ERM proteins and merlin. Integrators at the cell cortex. Nat. Rev. Mol. Cell Biol. 3, 586-599.
44. Hung, A. Y., and Sheng, M. (2002) PDZ domains. Structural modules for protein complex assembly. J. Biol. Chem. 277, 5699-5702.
45. Nourry, C., Grant, S. G., Borg, J.-P. (2003) PDZ domain proteins. Plug and play. Science's STKE 2003, RE7.
46. Hynes, T. R., Tang, L., Mervine, S. M., Sabo, J. L., Yost, E. A., Devreotes, P. N., and Berlot, C. B. (2004) Visualization of G proteinγδ dimers using bimolecular fluorescence complementation demonstrates roles for both β and γ subcellular targeting. J. Biol. Chem. 279, 30279-30286.
47. Griesbeck, O., Baird, G. S., Campbell, R. E., Zacharias, D. A., and Tsien, R. Y. (2001) Reducing the environmental sensitivity of yellow fluorescent protein. J. Biol. Chem. 276, 29188-29194.
48. Hall, R. A., Premont, R. T., Chow, C.-W., Blitzer, J. T., Pitcher, J. A., Claing, A., Stoffel, R. H., Barak, L. S., Shenolikar, S., Weinman, E. J., Grinstein, S., and Lefkowitz, R. J. (1998) The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+-exchange. Nature 392, 626-630.
49. Lamprecht, G., Weinman, E. J., and Yun, C.-H. (1998) The role of NHERF and E3KARP in the c-AMP-mediated inhibition of NHE3. J. Biol. Chem. 273, 29972-29978.
50. Yun, C.-H., Lamprecht, G., Forster, D. V., and Sidor, A. (1998) NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+-exchanger NHE3 and the cytoskeletal protein ezrin. J. Biol. Chem. 273, 25856-25863.
51. Livak, K. J., Schmittgen, T. D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2γδCt method. Methods 25, 402-408.
52. Kornfeld, R., and Kornfeld, S. (1985) Assembly of asparagine-linked oligosaccharides. Annu. Rev. Biochem. 54, 631-664.
53. Maley, F., Trimble, R. B., Tarentino, A. L., Plummer, T. H., Jr. (1989) Characterization of glycoproteins and their associated oligosaccharides through the use of endoglycosidases. Anal. Biochem. 180, 195-204.
54. Kerppola, T. K. (2008) Biomolecular fluorescence complementation (BiFC) analysis as a probe of protein interactions in living cells. Annu. Rev. Biophys. 37, 465-487.
55. Rao, R. M., Joy, Y., Leers-Sucheta, S., Bose, H. S., Miller, W. L., Azhar, S., and Stocco, D. M. (2003) Differential regulation of steroid hormone biosynthesis in R2C and MA-10 Leydig tumor cells. Role of SR-BI-mediated selective cholesteryl ester transport. Biol. Reprod. 68, 114-121.
56. Vergeer, M., Korporaal, S. J., Franssen, R., Meurs, I., Out, R., Hovingh, G. K., Hoekstra, M., Sierts, J. A., Dallinga-Thie, G. M., Motazacker, M. M., Holleboom, A. G., Van Berkel, T. J., Kastelein, J. J., Van Eck, M., and Kuivenhoven, J. A. (2011) Genetic variant of the scavenger receptor BI in humans. N. Engl. J. Med. 364, 136-145.
57. Lau, A. G., and Hall, R. A. (2001) Oligomerization of NHERF-1 and NHERF-2 PDZ domains. Differential regulation by association with receptor carboxyl-termini and by phosphorylation. Biochemistry 40, 8572-8580.
58. Minkoff, C., Shenolikar, S., and Weinman, E. J. (1999) Assembly of signaling complexes by sodium-hydrogen exchanger regulatory factor family of PDZ-containing proteins. Curr. Opin. Nephrol. Hypertens. 8, 603-608.
59. Weinman, E. J., Steplock, D., Wang, Y., and Shenolikar, S. (1995) Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na+-H+ exchanger. J. Clin. Invest. 95, 2143-2149.
60. Reczek, D., Berryman, M., Bretscher, A. (1997) Identification of EBP50. A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family. J. Cell Biol. 139, 169-179.
61. Yun, C. H., Oh, S., Zizak, M., Steplock, D., Tsao, S., Tse, C.-M., Weiman, E. J., and Donowitz, M. (1997) cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein. Proc. Natl. Acad. Sci. U.S.A. 94, 3010-3015.
62. Gisler, S. M., Stagljar, I., Traebert, M., Bacic, D., Biber, J., and Murer, H. (2001) Interaction of the type IIa Na/Pi cotransporter with PDZ proteins. J. Biol. Chem. 276, 9206-9213.
63. Scott, R. O., Thelin, W. R., and Milgram, S. L. (2002) A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable endotoxin receptor. J. Biol. Chem. 277, 22934-22941.
64. Ediger, T. R., Kraus, W. L., Weinman, E. J., and Katzenellenbogen, B. S. (1999) Estrogen receptor regulation of the Na+/H+ exchange regulatory factor. Endocrinology 140, 2976-2982.
65. Fanelli, T., Cardone, R. A., Favia, M., Guerra, L., Zaccolo, M., Monterisi, S., De Santis, T., Riccardi, S. M., Reshkin, S. J., and Casavola, V. (2008)β-Oestradiol rescues ΔF508CFTR functional expression in human cystic fibrosis airway CFBE41o cells through the up-regulation of NHERF1. Biol. Cell 100, 399-412.
66. Weinman, E. J., Hall, R. A., Friedman, P. A., Liu-Chen, L. Y., Shenolikar, S. (2006) The association of adaptor proteins with G protein-coupled receptors and receptor tyrosine kinases. Annu. Rev. Physiol. 68, 491-505.
67. Romero, G., von Zastrow, M., and Friedman, P. A. (2011) Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs. Means, motif, and opportunity. Adv. Pharmacol. 62, 279-314.
68. Sarker, R., Valkhoff, V. E., Zachos, N. C., Lin, R., Cha, B., Chen, T. E., Guggino, S., Zizak, M., de Jonge, H., Hogema, B., and Donowitz, M. (2011) NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity. Am. J. Physiol. Cell Physiol. 300, C771-C782.
69. Singh, A. K., Riederer, B., Krabbenhöft, A., Rausch, B., Bonhagen, J., Lehmann, U., de Jonge, H. R., Donowitz, M., Yun, C., Weinman, E. J., Kocher, O., Hogema, B. M., and Seidler, U. (2009) Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice. J. Clin. Invest. 119, 540-550.
70. Hall, R. A., Ostedgaard, L. S., Premont, R. T., Blitzer, J. T., Rahman, N., Welsh, M. J., Lefkowitz, R. J. (1998) A C-terminal motif found in the β2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. Proc. Natl. Acad. Sci, U.S.A. 95, 8496-8501.
71. Takahashi, Y., Morales, F. C., Kreimann, E. L., and Georgescu, M.-M. (2006) PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling. EMBO J. 25, 910-920.
72. Wheeler, D., Sneddon, W. B., Wang, B., Friedman, P. A., Romero, G. (2007) NHERF-1 and cytoskeleton regulate the traffic and membrane dynamics of G protein-coupled receptors. J. Biol. Chem. 282, 25076-25087.
73. Ardura, J. A., Wang, B., Watkins, S. C., Vilardaga, J.-P., and Friedman, P. A. (2011) Dynamic Na+-H+ exchanger regulatory factor-1 association and dissociation regulate parathyroid hormone receptor trafficking at membrane microdomains. J. Biol. Chem. 286, 35020-35029.
74. Slattery, C., Jenkin, K. A., Lee, A., Simcocks, A. C., McAinch, A. J., Poronnik, P., and Hryciw, D. H. (2011) Na+-H+ exchanger regulatory factor 1 (NHERF1) PDZ scaffold binds an internal binding site in the scavenger receptor megalin. Cell Physiol. Biochem. 27, 171-178.
75. Ritter, S. L., and Hall, R. A. (2009) Fine-tuning of GPCR activity by receptor-interacting proteins. Nat. Rev. Mol. Cell Biol. 10, 819-830.
76. Hammad, M. M., Kuang, Y.-Q., Yan, R., Allen, H., Dupré, D. J. (2010) Na+/H+ exchanger regulatory factor-1 is involved in chemokine receptor homodimer CCR5 internalization and signal transduction but does not affect CXCR4 homodimer or CXCR4-CCR5 heterodimer. J. Biol. Chem. 285, 34653-34664.
77. Nisar, S. P., Cunningham, M., Saxena, K., Pope, R. J., Kelly, E., and Mundell, S. J. (2012) Arrestin scaffolds NHERF1 to the P2Y12 receptor to regulate receptor internalization. J. Biol. Chem. 287, 24505-24515.
78. Hoque, M. T., and Cole, S. P. (2008) Down-regulation of Na+/H+ exchanger regulatory factor 1 increases expression and function of multidrug resistance protein 4. Cancer Res. 68, 4802-4809.
79. Sitaraman, S. V., Wang, L., Wong, M., Bruewer, M., Hobert, M., Yun, C. H., Merlin, D., Madara, J. L. (2002) The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation. J. Biol. Chem. 277, 33188-33195.
80. Padányi, R., Xiong, Y., Antalffy, G., Lór, K., Pászty, K., Strehler, E. E., Enyedi, A. (2010) Apical scaffolding protein NHERF2 modulates the lo-calization of alternatively spliced plasma membrane Ca2+ pump 2B variants in polarized epithelial cells. J. Biol. Chem. 285, 31704-31712.
81. Hwang, J. I., Heo, K., Shin, K. J., Kim, E., Yun, C., Ryu, S. H., Shin, H. S., and Suh, P. G. (2000) Regulation of phospholipase C- α3 activity by Na+/H+ exchanger regulatory factor 2. J. Biol. Chem. 275, 16632-16637.
82. Oh, Y.-S., Jo, N. W., Choi, W., Kim, H. S., Seo, S.-W., Kang, K.-O., Hwang, J.-I., Heo, K., Kim, S.-H., Kim, Y.-H., Kim, I.-H., Kim, J. H., Banno, Y., Ryu, S. O., and Suh, P.-G. (2004) NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C- α3 activation. Mol. Cell. Biol. 24, 5069-5079.
83. Paquet, M., Asay, M. J., Fam, S. R., Inuzuka, H., Castleberry, A. M., Oller, H., Smith, Y., Yun, C. C., Traynelis, S. F., and Hall, R. A. (2006) The PDZ scaffold NHERF-2 interacts with mGluR5 and regulates receptor activity. J. Biol. Chem. 281, 29949-29961.
84. Hryciw, D. H., Ekberg, J., Ferguson, C., Lee, A., Wang, D., Parton, R. G., Pollock, C. A., Yun, C. C., and Poronnik, P. (2006) Regulation of albumin endocytosis by PSD95/Dlg/ZO-1 (PDZ) scaffolds. Interaction of Na+-H+ exchange regulatory factor-2 with ClC-5. J. Biol. Chem. 281, 16068-16077.
85. Poulat, F., de Santa Barbara, P., Desclozeaux, M., Soullier, S., Moniot, B., Bonneaud, N., Boizet, B., and Berta, P. (1997) The human testis determing factor SRY binds a nuclear factor containing PDZ protein interaction domains. J. Biol. Chem. 272, 7167-7172.
86. Thevenet, L., Albrecht, K. H., Malki, S., Berta, P., Boizet-Bonhoure, B., and Poulat, F. (2005) NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY. J. Biol. Chem. 280, 38625-38630.
87. Lin, S., Yeruva, S., He, P., Singh, A. K., Zhang, H., Chen, M., Lamprecht, G., de Jonge, H. R., Tse, M., Donowitz, M., Hogema, B. M., Chun, J., Seidler, U., and Yun, C. C. (2010) Lysophosphatidic acid stimulates the intestinal brush border Na+/H+ exchanger 3 and fluid absorption via LPA5 and NHERF2. Gastroenterology 138, 649-658.