Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 17, 2009, Pages 5053-5055

  Matos, Maria Joao ^a,b   Viña, Dolores ^a   Picciau, Carmen ^a,b   Orallo, Francisco ^a   Santana, Lourdes ^a   Uriarte, Eugenio ^a  

^a Universidade de Santiago de Compostela   (Spain)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Coumarin resveratrol hybrids; MAOIs; Monoamino oxidase; Perkin reaction; Phenylcoumarins

Indexed keywords

3 (3' METHOXY)PHENYL 6 METHYLCOUMARIN; 5 METHYLSALICYLALDEHYDE; 6 METHYL 3 PHENYLCOUMARIN DERIVATIVE; COUMARIN DERIVATIVE; MONOAMINE OXIDASE A INHIBITOR; MONOAMINE OXIDASE B INHIBITOR; PHENYLACETIC ACID DERIVATIVE; RESVERATROL; SALICYLALDEHYDE; SELEGILINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROLYSIS; IC 50; NONHUMAN; PERKIN REACTION; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

COUMARINS; HUMANS; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PARKINSON DISEASE; PROTEIN ISOFORMS;

EID: 68349155549     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.039     Document Type: Article

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27. 3: C, 76.68; H, 5.30. Found: C, 76.76; H, 5.21.
28. 3: C, 76.68; H, 5.30. Found: C, 76.76; H, 5.22.
29. 3: C, 76.18; H, 4.79. Found: C, 75.99; H, 4.69.
30. 50 values shown in the table are expressed as means ± SEM from five experiments.