Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 10, 2011, Pages 4846-4852

  Secci, Daniela ^a   Carradori, Simone ^a   Bolasco, Adriana ^a   Chimenti, Paola ^a   Yáñez, Matilde ^b   Ortuso, Francesco ^c   Alcaro, Stefano ^c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Financial and Tributary Law Area   (Spain)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

Coumarin; Hydrazido; Hydrolytic stability; Monoamine oxidase

Indexed keywords

2 OXO 2H CHROMENE 3 CARBOXYLIC ACID N' (2 NITRO PHENYL) HYDRAZIDE; 2 OXO 2H CHROMENE 3 CARBOXYLIC ACID N' (2,4 DINITROPHENYL) HYDRAZIDE; 2 OXO 2H CHROMENE 3 CARBOXYLIC ACID N' (4 CHLORPHENYL)HYDRAZIDE; 3 ACETYL 8 BROMO 6 CHLORO 2H CHROMEN 2 ONE; 3 BENZOYL 6 HYDROXY 2H CHROMEN 2 ONE; 3 BENZOYL 8 BROMO 6 CHLORO 2H CHROMEN 2 ONE; 7 (3 CHLOROBENZYLOXY) 2 OXO 2H CHROMENE 3 CARBOXYLIC ACID; 7 (3,4 CHLOROBENZYLOXY) 2 OXO 2H CHROMENE 3 CARBOXYLIC ACID; 7 (4 TERTBUTYLBENZYLOXY) 2 OXO 2H CHROMENE 3 CARBOXYLIC ACID; 7 (CYCLOHEPTYLOXY) 2 OXO 2H CHROMENE 3 CARBOXYLIC ACID; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CARBONYL DERIVATIVE; CARBOXYL GROUP; COUMARIN DERIVATIVE; ESTER DERIVATIVE; ETHYL 7 (3 CHLOROBENZYLOXY) 2 OXO 2H CHROMENE 3 CARBOXYLATE; ETHYL 7 (3,4 CHLOROBENZYLOXY) 2 OXO 2H CHROMENE 3 CARBOXYLATE; ETHYL 7 (4 TERT BUTYLBENZYLOXY) 2 OXO 2H CHROMENE 3 CARBOXYLATE; ETHYL 7 (CYCLOHEPTYLOXY) 2 OXO 2H CHROMENE 3 CARBOXYLATE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG HYDROLYSIS; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; SUBSTITUTION REACTION;

COUMARINS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80053187018     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.07.017     Document Type: Article

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