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Volumn 12, Issue 7, 2014, Pages 809-816

The pediatric sepsis biomarker risk model: Potential implications for sepsis therapy and biology

Author keywords

Biomarker; Pediatric; PERSEVERE; Risk stratification; Sepsis

Indexed keywords

GRANZYME B; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 70KDA 1B; INTERLEUKIN 1ALPHA; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; NEUTROPHIL COLLAGENASE; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; GRANZYME;

EID: 84902504618     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/14787210.2014.912131     Document Type: Review
Times cited : (27)

References (59)
  • 1
    • 0037451929 scopus 로고    scopus 로고
    • The epidemiology of sepsis in the United States from 1979 through 2000
    • Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003;348(16):1546-54
    • (2003) N Engl J Med , vol.348 , Issue.16 , pp. 1546-1554
    • Martin, G.S.1    Mannino, D.M.2    Eaton, S.3    Moss, M.4
  • 2
    • 84875591100 scopus 로고    scopus 로고
    • Pediatric sepsis: Challenges and adjunctive therapies
    • Hanna W, Wong HR. Pediatric sepsis: challenges and adjunctive therapies. Crit Care Clin 2013;29(2):203-22
    • (2013) Crit Care Clin , vol.29 , Issue.2 , pp. 203-222
    • Hanna, W.1    Wong, H.R.2
  • 3
    • 0037180768 scopus 로고    scopus 로고
    • The immunopathogenesis of sepsis
    • Cohen J. The immunopathogenesis of sepsis. Nature 2002;420(6917):885-91
    • (2002) Nature , vol.420 , Issue.6917 , pp. 885-891
    • Cohen, J.1
  • 4
    • 84880950517 scopus 로고    scopus 로고
    • Sepsis: Multiple abnormalities, heterogeneous responses, and evolving understanding
    • Iskander KN, Osuchowski MF, Stearns-Kurosawa DJ, et al. Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol Rev 2013; 93(3):1247-88
    • (2013) Physiol Rev , vol.93 , Issue.3 , pp. 1247-1288
    • Iskander, K.N.1    Osuchowski, M.F.2    Stearns-Kurosawa, D.J.3
  • 5
    • 84887073310 scopus 로고    scopus 로고
    • Role of biomarkers in sepsis care
    • Samraj RS, Zingarelli B, Wong HR. Role of biomarkers in sepsis care. Shock 2013; 40(5):358-65
    • (2013) Shock , vol.40 , Issue.5 , pp. 358-365
    • Samraj, R.S.1    Zingarelli, B.2    Wong, H.R.3
  • 6
    • 84866792152 scopus 로고    scopus 로고
    • The pediatric sepsis biomarker risk model
    • Wong HR, Salisbury S, Xiao Q, et al. The pediatric sepsis biomarker risk model. Crit Care 2012;16(5):R174
    • (2012) Crit Care , vol.16 , Issue.5
    • Wong, H.R.1    Salisbury, S.2    Xiao, Q.3
  • 7
    • 84897378910 scopus 로고    scopus 로고
    • Testing the prognostic accuracy of the update pediatric sepsis biomarker risk model
    • Wong HR, Weiss SL, Giuliano JS Jr, et al. Testing the prognostic accuracy of the update pediatric sepsis biomarker risk model. PLoS One 2014;9:e86242
    • (2014) PLoS One , vol.9
    • Wong, H.R.1    Weiss, S.L.2    Giuliano Jr., J.S.3
  • 8
    • 79953087339 scopus 로고    scopus 로고
    • Biomarker discovery and development in pediatric critical care medicine
    • Kaplan JM, Wong HR. Biomarker discovery and development in pediatric critical care medicine. Pediatr Crit Care Med 2011;12(2):165-73
    • (2011) Pediatr Crit Care Med , vol.12 , Issue.2 , pp. 165-173
    • Kaplan, J.M.1    Wong, H.R.2
  • 9
    • 84877346216 scopus 로고    scopus 로고
    • Genome-wide expression profiling in pediatric septic shock
    • Wong HR. Genome-wide expression profiling in pediatric septic shock. Pediatr Res 2013;73(4 Pt 2):564-9
    • (2013) Pediatr Res , vol.73 , Issue.4 PART 2 , pp. 564-569
    • Wong, H.R.1
  • 10
    • 84896595576 scopus 로고    scopus 로고
    • A multibiomarker-based outcome risk stratification model for adult septic shock
    • Wong HR, Lindsell CJ, Pettila V, et al. A multibiomarker-based outcome risk stratification model for adult septic shock. Crit Care Med 2014;42(4):781-9
    • (2014) Crit Care Med , vol.42 , Issue.4 , pp. 781-789
    • Wong, H.R.1    Lindsell, C.J.2    Pettila, V.3
  • 12
    • 84857616057 scopus 로고    scopus 로고
    • Increased granzyme levels in cytotoxic T lymphocytes are associated with disease severity in emergency department patients with severe sepsis
    • Napoli AM, Fast LD, Gardiner F, et al. Increased granzyme levels in cytotoxic T lymphocytes are associated with disease severity in emergency department patients with severe sepsis. Shock 2012;37(3):257-62
    • (2012) Shock , vol.37 , Issue.3 , pp. 257-262
    • Napoli, A.M.1    Fast, L.D.2    Gardiner, F.3
  • 13
    • 33750288937 scopus 로고    scopus 로고
    • Apoptosis and caspases regulate death and inflammation in sepsis
    • Hotchkiss RS, Nicholson DW. Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol 2006;6(11):813-22
    • (2006) Nat Rev Immunol , vol.6 , Issue.11 , pp. 813-822
    • Hotchkiss, R.S.1    Nicholson, D.W.2
  • 14
    • 63249101191 scopus 로고    scopus 로고
    • Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity
    • Freishtat RJ, Natale J, Benton AS, et al. Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity. Am J Respir Crit Care Med 2009;179(6):467-73
    • (2009) Am J Respir Crit Care Med , vol.179 , Issue.6 , pp. 467-473
    • Freishtat, R.J.1    Natale, J.2    Benton, A.S.3
  • 15
    • 17044387386 scopus 로고    scopus 로고
    • Hsp70 chaperones: Cellular functions and molecular mechanism
    • Mayer MP, Bukau B. Hsp70 chaperones: cellular functions and molecular mechanism. Cell Mol Life Sci 2005;62(6):670-84
    • (2005) Cell Mol Life Sci , vol.62 , Issue.6 , pp. 670-684
    • Mayer, M.P.1    Bukau, B.2
  • 16
    • 33751203833 scopus 로고    scopus 로고
    • Heat shock proteins 27 and 70: Anti-apoptotic proteins with tumorigenic properties
    • Garrido C, Brunet M, Didelot C, et al. Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties. Cell Cycle 2006;5(22):2592-601
    • (2006) Cell Cycle , vol.5 , Issue.22 , pp. 2592-2601
    • Garrido, C.1    Brunet, M.2    Didelot, C.3
  • 17
    • 0028035112 scopus 로고
    • Protective effects of hsp70 in inflammation
    • Jacquier-Sarlin MR, Fuller K, Dinh-Xuan AT, et al. Protective effects of hsp70 in inflammation. Experientia 1994; 50(11-12):1031-8
    • (1994) Experientia , vol.50 , Issue.11-12 , pp. 1031-1038
    • Jacquier-Sarlin, M.R.1    Fuller, K.2    Dinh-Xuan, A.T.3
  • 18
    • 0026703222 scopus 로고
    • Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity
    • Jaattela M, Wissing D, Bauer PA, Li GC. Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity. EMBO J 1992;11(10):3507-12
    • (1992) EMBO J , vol.11 , Issue.10 , pp. 3507-3512
    • Jaattela, M.1    Wissing, D.2    Bauer, P.A.3    Li, G.C.4
  • 19
    • 84862805903 scopus 로고    scopus 로고
    • Stimulation of TLR4 by recombinant HSP70 requires structural integrity of the HSP70 protein itself
    • Luong M, Zhang Y, Chamberlain T, et al. Stimulation of TLR4 by recombinant HSP70 requires structural integrity of the HSP70 protein itself. J Inflamm (Lond) 2012;9:11
    • (2012) J Inflamm (Lond) , vol.9 , pp. 11
    • Luong, M.1    Zhang, Y.2    Chamberlain, T.3
  • 20
    • 41149118513 scopus 로고    scopus 로고
    • How dying cells alert the immune system to danger
    • Kono H, Rock KL. How dying cells alert the immune system to danger. Nat Rev Immunol 2008;8(4):279-89
    • (2008) Nat Rev Immunol , vol.8 , Issue.4 , pp. 279-289
    • Kono, H.1    Rock, K.L.2
  • 21
    • 79953186909 scopus 로고    scopus 로고
    • The role of heat shock protein 70 in mediating age-dependent mortality in sepsis
    • McConnell KW, Fox AC, Clark AT, et al. The role of heat shock protein 70 in mediating age-dependent mortality in sepsis. J Immunol 2011;186(6):3718-25
    • (2011) J Immunol , vol.186 , Issue.6 , pp. 3718-3725
    • McConnell, K.W.1    Fox, A.C.2    Clark, A.T.3
  • 22
    • 0035210971 scopus 로고    scopus 로고
    • Protective functions of intracellular heat-shock protein (HSP) 70-expression in patients with severe sepsis
    • Bruemmer-Smith S, Stuber F, Schroeder S. Protective functions of intracellular heat-shock protein (HSP) 70-expression in patients with severe sepsis. Intensive Care Med 2001;27(12):1835-41
    • (2001) Intensive Care Med , vol.27 , Issue.12 , pp. 1835-1841
    • Bruemmer-Smith, S.1    Stuber, F.2    Schroeder, S.3
  • 23
    • 23744513067 scopus 로고    scopus 로고
    • Parenteral glutamine increases serum heat shock protein 70 in critically ill patients
    • Ziegler TR, Ogden LG, Singleton KD, et al. Parenteral glutamine increases serum heat shock protein 70 in critically ill patients. Intensive Care Med 2005;31(8): 1079-86
    • (2005) Intensive Care Med , vol.31 , Issue.8 , pp. 1079-1086
    • Ziegler, T.R.1    Ogden, L.G.2    Singleton, K.D.3
  • 24
    • 0036234920 scopus 로고    scopus 로고
    • Serum levels of Hsp 72 measured early after trauma correlate with survival
    • discussion 617
    • Pittet JF, Lee H, Morabito D, et al. Serum levels of Hsp 72 measured early after trauma correlate with survival. J Trauma 2002;52(4):611-17. discussion 617
    • (2002) J Trauma , vol.52 , Issue.4 , pp. 611-617
    • Pittet, J.F.1    Lee, H.2    Morabito, D.3
  • 27
    • 84887459924 scopus 로고    scopus 로고
    • Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype
    • McCarthy DA, Clark RR, Bartling TR, et al. Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype. J Biol Chem 2013; 288(45):32149-59
    • (2013) J Biol Chem , vol.288 , Issue.45 , pp. 32149-32159
    • McCarthy, D.A.1    Clark, R.R.2    Bartling, T.R.3
  • 28
    • 78649507655 scopus 로고    scopus 로고
    • Differential susceptibility to lethal endotoxaemia in mice deficient in IL-1alpha, IL-1beta or IL-1 receptor type i
    • Joosten LA, Van De Veerdonk FL, Vonk AG, et al. Differential susceptibility to lethal endotoxaemia in mice deficient in IL-1alpha, IL-1beta or IL-1 receptor type I. APMIS 2010;118(12):1000-7
    • (2010) APMIS , vol.118 , Issue.12 , pp. 1000-1007
    • Joosten, L.A.1    Van De Veerdonk, F.L.2    Vonk, A.G.3
  • 29
    • 0030281494 scopus 로고    scopus 로고
    • Interleukin 8 as a novel target for intervention therapy in acute inflammatory diseases
    • Harada A, Mukaida N, Matsushima K. Interleukin 8 as a novel target for intervention therapy in acute inflammatory diseases. Mol Med Today 1996;2(11):482-9
    • (1996) Mol Med Today , vol.2 , Issue.11 , pp. 482-489
    • Harada, A.1    Mukaida, N.2    Matsushima, K.3
  • 30
    • 78649397052 scopus 로고    scopus 로고
    • The role of endothelial interleukin-8/NADPH oxidase 1 axis in sepsis
    • Miyoshi T, Yamashita K, Arai T, et al. The role of endothelial interleukin-8/NADPH oxidase 1 axis in sepsis. Immunology 2010; 131(3):331-9
    • (2010) Immunology , vol.131 , Issue.3 , pp. 331-339
    • Miyoshi, T.1    Yamashita, K.2    Arai, T.3
  • 31
    • 84886732783 scopus 로고    scopus 로고
    • Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome
    • Ware LB, Koyama T, Zhao Z, et al. Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome. Crit Care 2013;17(5):R253
    • (2013) Crit Care , vol.17 , Issue.5
    • Ware, L.B.1    Koyama, T.2    Zhao, Z.3
  • 32
    • 48249148704 scopus 로고    scopus 로고
    • Interleukin-8 as a stratification tool for interventional trials involving pediatric septic shock
    • Wong HR, Cvijanovich N, Wheeler DS, et al. Interleukin-8 as a stratification tool for interventional trials involving pediatric septic shock. Am J Respir Crit Care Med 2008;178(3):276-82
    • (2008) Am J Respir Crit Care Med , vol.178 , Issue.3 , pp. 276-282
    • Wong, H.R.1    Cvijanovich, N.2    Wheeler, D.S.3
  • 33
    • 77953081638 scopus 로고    scopus 로고
    • Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock
    • Calfee CS, Thompson BT, Parsons PE, et al. Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock. Crit Care Med 2010;38(6):1436-41
    • (2010) Crit Care Med , vol.38 , Issue.6 , pp. 1436-1441
    • Calfee, C.S.1    Thompson, B.T.2    Parsons, P.E.3
  • 34
    • 0030056856 scopus 로고    scopus 로고
    • The role of MIP-1 alpha in inflammation and hematopoiesis
    • Cook DN. The role of MIP-1 alpha in inflammation and hematopoiesis. J Leukoc Biol 1996;59(1):61-6
    • (1996) J Leukoc Biol , vol.59 , Issue.1 , pp. 61-66
    • Cook, D.N.1
  • 35
    • 0028984574 scopus 로고
    • Macrophage inflammatory protein-1 alpha mediates lung leukocyte recruitment, lung capillary leak, and early mortality in murine endotoxemia
    • Standiford TJ, Kunkel SL, Lukacs NW, et al. Macrophage inflammatory protein-1 alpha mediates lung leukocyte recruitment, lung capillary leak, and early mortality in murine endotoxemia. J Immunol 1995;155(3):1515-24
    • (1995) J Immunol , vol.155 , Issue.3 , pp. 1515-1524
    • Standiford, T.J.1    Kunkel, S.L.2    Lukacs, N.W.3
  • 36
    • 0037108502 scopus 로고    scopus 로고
    • An increase in the susceptibility of burned patients to infectious complications due to impaired production of macrophage inflammatory protein 1 alpha
    • Kobayashi M, Takahashi H, Sanford AP, et al. An increase in the susceptibility of burned patients to infectious complications due to impaired production of macrophage inflammatory protein 1 alpha. J Immunol 2002;169(8):4460-6
    • (2002) J Immunol , vol.169 , Issue.8 , pp. 4460-4466
    • Kobayashi, M.1    Takahashi, H.2    Sanford, A.P.3
  • 38
    • 0032946181 scopus 로고    scopus 로고
    • Detection of macrophage inflammatory protein (MIP)-1alpha and MIP-1beta during experimental endotoxemia and human sepsis
    • O'Grady NP, Tropea M, Preas HL 2nd, et al. Detection of macrophage inflammatory protein (MIP)-1alpha and MIP-1beta during experimental endotoxemia and human sepsis. J Infect Dis 1999;179(1):136-41
    • (1999) J Infect Dis , vol.179 , Issue.1 , pp. 136-141
    • O'grady, N.P.1    Tropea, M.2    Preas, I.I.H.L.3
  • 39
    • 0032077060 scopus 로고    scopus 로고
    • Chemokines and chemotaxis of leukocytes in infectious meningitis
    • Lahrtz F, Piali L, Spanaus KS, et al. Chemokines and chemotaxis of leukocytes in infectious meningitis. J Neuroimmunol 1998;85(1):33-43
    • (1998) J Neuroimmunol , vol.85 , Issue.1 , pp. 33-43
    • Lahrtz, F.1    Piali, L.2    Spanaus, K.S.3
  • 40
    • 0031041656 scopus 로고    scopus 로고
    • Activation of human matrix metalloproteinases by various bacterial proteinases
    • Okamoto T, Akaike T, Suga M, et al. Activation of human matrix metalloproteinases by various bacterial proteinases. J Biol Chem 1997;272(9): 6059-66
    • (1997) J Biol Chem , vol.272 , Issue.9 , pp. 6059-6066
    • Okamoto, T.1    Akaike, T.2    Suga, M.3
  • 41
    • 36049005089 scopus 로고    scopus 로고
    • Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation
    • Van Lint P, Libert C. Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation. J Leukoc Biol 2007;82(6):1375-81
    • (2007) J Leukoc Biol , vol.82 , Issue.6 , pp. 1375-1381
    • Van Lint, P.1    Libert, C.2
  • 42
    • 84856183793 scopus 로고    scopus 로고
    • A novel role for matrix metalloproteinase-8 in sepsis
    • Solan PD, Dunsmore KE, Denenberg AG, et al. A novel role for matrix metalloproteinase-8 in sepsis. Crit Care Med 2012;40(2):379-87
    • (2012) Crit Care Med , vol.40 , Issue.2 , pp. 379-387
    • Solan, P.D.1    Dunsmore, K.E.2    Denenberg, A.G.3
  • 43
    • 80054091646 scopus 로고    scopus 로고
    • Serum MMP-8,-9 and TIMP-1 in sepsis: High serum levels of MMP-8 and TIMP-1 are associated with fatal outcome in a multicentre, prospective cohort study
    • Lauhio A, Hastbacka J, Pettila V, et al. Serum MMP-8,-9 and TIMP-1 in sepsis: high serum levels of MMP-8 and TIMP-1 are associated with fatal outcome in a multicentre, prospective cohort study. Hypothetical impact of tetracyclines. Pharmacol Res 2011;64(6):590-4
    • (2011) Hypothetical Impact of Tetracyclines. Pharmacol Res , vol.64 , Issue.6 , pp. 590-594
    • Lauhio, A.1    Hastbacka, J.2    Pettila, V.3
  • 44
    • 84863919429 scopus 로고    scopus 로고
    • Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases
    • Vandenbroucke RE, Dejonckheere E, Van Lint P, et al. Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases. J Neurosci 2012;32(29):9805-16
    • (2012) J Neurosci , vol.32 , Issue.29 , pp. 9805-9816
    • Vandenbroucke, R.E.1    Dejonckheere, E.2    Van Lint, P.3
  • 45
    • 77951855187 scopus 로고    scopus 로고
    • The host response to sepsis and developmental impact
    • Wynn J, Cornell TT, Wong HR, et al. The host response to sepsis and developmental impact. Pediatrics 2010;125(5):1031-41
    • (2010) Pediatrics , vol.125 , Issue.5 , pp. 1031-1041
    • Wynn, J.1    Cornell, T.T.2    Wong, H.R.3
  • 46
    • 3142628083 scopus 로고    scopus 로고
    • IL-1beta induces an exaggerated proand anti-inflammatory response in peritoneal macrophages of children compared with adults
    • Barsness KA, Bensard DD, Partrick DA, et al. IL-1beta induces an exaggerated proand anti-inflammatory response in peritoneal macrophages of children compared with adults. Pediatr Surg Int 2004;20(4):238-42
    • (2004) Pediatr Surg Int , vol.20 , Issue.4 , pp. 238-242
    • Barsness, K.A.1    Bensard, D.D.2    Partrick, D.A.3
  • 47
    • 3042618682 scopus 로고    scopus 로고
    • Endotoxin induces an exaggerated interleukin-10 response in peritoneal macrophages of children compared with adults
    • discussion 912-5
    • Barsness KA, Bensard DD, Partrick DA, et al. Endotoxin induces an exaggerated interleukin-10 response in peritoneal macrophages of children compared with adults. J Pediatr Surg 2004;39(6):912-15. discussion 912-5
    • (2004) J Pediatr Surg , vol.39 , Issue.6 , pp. 912-915
    • Barsness, K.A.1    Bensard, D.D.2    Partrick, D.A.3
  • 49
    • 0027788004 scopus 로고
    • Expression of interleukin-1 alpha and beta in early passage fibroblasts from aging individuals
    • Kumar S, Vinci JM, Millis AJ, Baglioni C. Expression of interleukin-1 alpha and beta in early passage fibroblasts from aging individuals. Exp Gerontol 1993;28(6): 505-13
    • (1993) Exp Gerontol , vol.28 , Issue.6 , pp. 505-513
    • Kumar, S.1    Vinci, J.M.2    Millis, A.J.3    Baglioni, C.4
  • 50
    • 84862766869 scopus 로고    scopus 로고
    • A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis
    • Boomer JS, Shuherk-Shaffer J, Hotchkiss RS, Green JM. A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis. Crit Care 2012;16(3):R112
    • (2012) Crit Care , vol.16 , Issue.3
    • Boomer, J.S.1    Shuherk-Shaffer, J.2    Hotchkiss, R.S.3    Green, J.M.4
  • 51
    • 84888325490 scopus 로고    scopus 로고
    • Sepsis-induced immunosuppression: From cellular dysfunctions to immunotherapy
    • Hotchkiss RS, Monneret G, Payen D. Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 2013;13(12):862-74
    • (2013) Nat Rev Immunol , vol.13 , Issue.12 , pp. 862-874
    • Hotchkiss, R.S.1    Monneret, G.2    Payen, D.3
  • 52
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med 2003;348(2):138-50
    • (2003) N Engl J Med , vol.348 , Issue.2 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 53
    • 84898013136 scopus 로고    scopus 로고
    • The temporal version of the pediatric sepsis biomarker risk model
    • Wong HR, Weiss SL, Giuliano JS Jr, et al. The temporal version of the pediatric sepsis biomarker risk model. PLoS One 2014;9(3): e92121
    • (2014) PLoS One , vol.9 , Issue.3
    • Wong, H.R.1    Weiss, S.L.2    Giuliano Jr., J.S.3
  • 54
    • 59749100172 scopus 로고    scopus 로고
    • Potential of immunomodulatory agents for prevention and treatment of neonatal sepsis
    • Wynn JL, Neu J, Moldawer LL, Levy O. Potential of immunomodulatory agents for prevention and treatment of neonatal sepsis. J Perinatol 2009;29(2):79-88
    • (2009) J Perinatol , vol.29 , Issue.2 , pp. 79-88
    • Wynn, J.L.1    Neu, J.2    Moldawer, L.L.3    Levy, O.4
  • 55
    • 84893319736 scopus 로고    scopus 로고
    • Post-ICU Admission Fluid Balance and Pediatric Septic Shock Outcomes: A Risk-Stratified Analysis
    • Abulebda K, Cvijanovich NZ, Thomas NJ, et al. Post-ICU Admission Fluid Balance and Pediatric Septic Shock Outcomes: a Risk-Stratified Analysis. Crit Care Med 2014;42(2):397-403
    • (2014) Crit Care Med , vol.42 , Issue.2 , pp. 397-403
    • Abulebda, K.1    Cvijanovich, N.Z.2    Thomas, N.J.3
  • 56
    • 8544262221 scopus 로고    scopus 로고
    • Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab') 2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels
    • Panacek EA, Marshall JC, Albertson TE, et al. Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab') 2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit Care Med 2004; 32(11):2173-82
    • (2004) Crit Care Med , vol.32 , Issue.11 , pp. 2173-2182
    • Panacek, E.A.1    Marshall, J.C.2    Albertson, T.E.3
  • 58
    • 84897545788 scopus 로고    scopus 로고
    • Is H NMR metabolomics becoming the promising early biomarker for neonatal sepsis and for monitoring the antibiotic toxicity?
    • Epub ahead of print
    • Noto A, Mussap M, Fanos V. Is H NMR metabolomics becoming the promising early biomarker for neonatal sepsis and for monitoring the antibiotic toxicity? J Chemother 2013. [Epub ahead of print]
    • (2013) J Chemother
    • Noto, A.1    Mussap, M.2    Fanos, V.3
  • 59
    • 84877128328 scopus 로고    scopus 로고
    • Metabolomics as a novel approach for early diagnosis of pediatric septic shock and its mortality
    • Mickiewicz B, Vogel HJ, Wong HR, Winston BW. Metabolomics as a novel approach for early diagnosis of pediatric septic shock and its mortality. Am J Respir Crit Care Med 2013;187(9):967-76
    • (2013) Am J Respir Crit Care Med , vol.187 , Issue.9 , pp. 967-976
    • Mickiewicz, B.1    Vogel, H.J.2    Wong, H.R.3    Winston, B.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.