The pediatric sepsis biomarker risk model

Critical Care

Volumn 16, Issue 5, 2012, Pages

  Wong, Hector R ^a,b   Salisbury, Shelia ^b   Xiao, Qiang ^c   Cvijanovich, Natalie Z ^d   Hall, Mark ^e   Allen, Geoffrey L ^f   Thomas, Neal J ^g   Freishtat, Robert J ^h   Anas, Nick ⁱ   Meyer, Keith ^j   Checchia, Paul A ^k   Lin, Richard ^l   Shanley, Thomas P ^m   Bigham, Michael T ⁿ   Sen, Anita ^o   Nowak, Jeffrey ^p   Quasney, Michael ^q   Henricksen, Jared W ^r   Chopra, Arun ^s   Banschbach, Sharon ^a   Beckman, Eileen ^a   Harmon, Kelli ^a   Lahni, Patrick ^a   Lindsell, Christopher J ^b   more..

^a CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c The EMD Millipore Corporation   (United States)

^d CHILDREN S HOSPITAL OAKLAND   (United States)

^e NATIONWIDE CHILDREN S HOSPITAL   (United States)

^f CHILDREN S MERCY HOSPITAL   (United States)

^g PENN STATE CHILDREN S HOSPITAL   (United States)

^h CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

ⁱ CHILDREN S HOSPITAL OF ORANGE COUNTY   (United States)

^j MIAMI CHILDREN'S HOSPITAL   (United States)

^k TEXAS CHILDREN S HOSPITAL   (United States)

^l CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^m UNIVERSITY OF MICHIGAN   (United States)

ⁿ AKRON CHILDREN'S HOSPITAL   (United States)

^o NewYork Presbyterian Hospital   (United States)

^p CHILDREN S HOSPITALS AND CLINICS OF MINNESOTA   (United States)

^q CHILDREN S HOSPITAL OF WISCONSIN   (United States)

^r PRIMARY CHILDREN'S MEDICAL CENTER   (United States)

^s ST CHRISTOPHER'S HOSPITAL FOR CHILDREN   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; ELASTASE; ELASTASE II; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN A1 BETA; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; UNCLASSIFIED DRUG;

ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; CHILD; CHILDHOOD DISEASE; CHILDHOOD MORTALITY; CLASSIFICATION AND REGRESSION TREE ANALYSIS; DISEASE SEVERITY; FALSE POSITIVE RESULT; FEMALE; GENE EXPRESSION PROFILING; GENOME; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MEDICAL DECISION MAKING; MULTIPLE ORGAN FAILURE; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; PREDICTIVE VALUE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN ANALYSIS; RISK ASSESSMENT; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY; SEPTIC SHOCK; SURVIVAL; BLOOD; COHORT ANALYSIS; INFANT; SEPSIS; THEORETICAL MODEL; TRENDS;

BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; HUMANS; INFANT; INTENSIVE CARE UNITS, PEDIATRIC; MALE; MODELS, THEORETICAL; RISK ASSESSMENT; SEPSIS;

EID: 84866792152     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc11652     Document Type: Article

References (30)

1. Czaja AS, Zimmerman JJ, Nathens AB. Readmission and late mortality after pediatric severe sepsis. Pediatrics 2009, 123:849-857. 10.1542/peds.2008-0856, 19255013.
2. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008, 36:296-327. 10.1097/01.CCM.0000298158.12101.41, 18158437.
3. Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med 2007, 35:1244-1250. 10.1097/01.CCM.0000261890.41311.E9, 17414736.
4. Watson RS, Carcillo JA, Linde-Zwirble WT, Clermont G, Lidicker J, Angus DC. The epidemiology of severe sepsis in children in the United States. Am J Resp Crit Care Med 2003, 167:695-701. 10.1164/rccm.200207-682OC, 12433670.
5. Marshall JC. Sepsis: rethinking the approach to clinical research. J Leukoc Biol 2008, 83:471-482.
6. Marshall JC, Reinhart K. Biomarkers of sepsis. Crit Care Med 2009, 37:2290-2298. 10.1097/CCM.0b013e3181a02afc, 19487943.
7. Cvijanovich N, Shanley TP, Lin R, Allen GL, Thomas NJ, Checchia P, Anas N, Freishtat RJ, Monaco M, Odoms K, Sakthivel B, Wong HR. Validating the genomic signature of pediatric septic shock. Physiol Genomics 2008, 34:127-134. 10.1152/physiolgenomics.00025.2008, 2440641, 18460642.
8. Shanley TP, Cvijanovich N, Lin R, Allen GL, Thomas NJ, Doctor A, Kalyanaraman M, Tofil NM, Penfil S, Monaco M, Odoms K, Barnes M, Sakthivel B, Aronow BJ, Wong HR. Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock. Mol Med 2007, 13:495-508. 2014731, 17932561.
9. Wong HR, Cvijanovich N, Allen GL, Lin R, Anas N, Meyer K, Freishtat RJ, Monaco M, Odoms K, Sakthivel B, Shanley TP. Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum. Crit Care Med 2009, 37:1558-1566. 10.1097/CCM.0b013e31819fcc08, 2747356, 19325468.
10. Wong HR, Cvijanovich N, Lin R, Allen GL, Thomas NJ, Willson DF, Freishtat RJ, Anas N, Meyer K, Checchia PA, Monaco M, Odoms K, Shanley TP. Identification of pediatric septic shock subclasses based on genome-wide expression profiling. BMC Med 2009, 7:34. 10.1186/1741-7015-7-34, 2720987, 19624809.
11. Wong HR, Freishtat RJ, Monaco M, Odoms K, Shanley TP. Leukocyte subset-derived genome-wide expression profiles in pediatric septic shock. Pediatr Crit Care Med 2009, 11:349-355.
12. Wong HR, Shanley TP, Sakthivel B, Cvijanovich N, Lin R, Allen GL, Thomas NJ, Doctor A, Kalyanaraman M, Tofil NM, Penfil S, Monaco M, Tagavilla MA, Odoms K, Dunsmore K, Barnes M, Aronow BJ. Genome level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol Genomics 2007, 30:146-155. 10.1152/physiolgenomics.00024.2007, 2770262, 17374846.
13. Wong HR, Wheeler DS, Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Doughty LA. Toward a clinically feasible gene expression-based subclassification strategy for septic shock: proof of concept. Crit Care Med 38:1955-1961.
14. Solan PD, Dunsmore KE, Denenberg AG, Odoms K, Zingarelli B, Wong HR. A novel role for matrix metalloproteinase-8 in sepsis. Crit Care Med 2012, 40:379-387. 10.1097/CCM.0b013e318232e404, 22020238.
15. Wong HR. Genetics and genomics in pediatric septic shock. Crit Care Med 2012, 40:1618-1626. 10.1097/CCM.0b013e318246b546, 22511139.
16. Wong HR. Clinical review: Sepsis and septic shock - the potential of gene arrays. Crit Care 2012, 16:204. 10.1186/cc10811, 22316118.
17. Basu RK, Standage SW, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Lin R, Shanley TP, Bigham MT, Wheeler DS, Deverajan P, Goldstein SL, Wong HR. Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray. Crit Care 2011, 15:R273. 10.1186/cc10554, 3388679, 22098946.
18. Standage SW, Wong HR. Biomarkers for pediatric sepsis and septic shock. Expert Rev Anti Infect Ther 2011, 9:71-79. 10.1586/eri.10.154, 3033193, 21171879.
19. Kaplan JM, Wong HR. Biomarker discovery and development in pediatric critical care medicine. Pediatr Crit Care Med 2011, 12:165-173. 10.1097/PCC.0b013e3181e28876, 2924462, 20473243.
20. Goldstein B, Giroir B, Randolph A. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 2005, 6:2-8. 10.1097/01.PCC.0000149131.72248.E6, 15636651.
21. Pollack MM, Patel KM, Ruttimann UE. The Pediatric Risk of Mortality III--Acute Physiology Score (PRISM III-APS): a method of assessing physiologic instability for pediatric intensive care unit patients. J Pediatr 1997, 131:575-581. 10.1016/S0022-3476(97)70065-9, 9386662.
22. Muller R, Mockel M. Logistic regression and CART in the analysis of multimarker studies. Clinica Chimica Acta 2008, 394:1-6.
23. VassarStats Website for Statistical Computation. , http://faculty.vassar.edu/lowry/VassarStats.html
24. Fonarow GC, Adams KF, Abraham WT, Yancy CW, Boscardin WJ. Risk stratification for in-hospital mortality in acutely decompensated heart failure: classification and regression tree analysis. JAMA 2005, 293:572-580. 10.1001/jama.293.5.572, 15687312.
25. Nadel S, Goldstein B, Williams MD, Dalton H, Peters M, Macias WL, Abd-Allah SA, Levy H, Angle R, Wang D, Sundin DP, . Giroir Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial. Lancet 2007, 369:836-843. 10.1016/S0140-6736(07)60411-5, 17350452, Giroir.
26. Watson RS, Carcillo JA. Scope and epidemiology of pediatric sepsis. Pediatr Crit Care Med 2005, 6:S3-5. 10.1097/01.PCC.0000161289.22464.C3, 15857554.
27. Wong HR, Cvijanovich N, Wheeler DS, Bigham MT, Monaco M, Odoms K, Macias WL, Williams MD. Interleukin-8 as a stratification tool for interventional trials involving pediatric septic shock. Am J Resp Crit Care Med 2008, 178:276-282. 10.1164/rccm.200801-131OC, 2542425, 18511707.
28. Freishtat RJ, Natale J, Benton AS, Cohen J, Sharron M, Wiles AA, Ngor WM, Mojgani B, Bradbury M, Degnan A, Sachdeva R, Debiase LM, Ghimbovschi S, Chow M, Bunag C, Kristosturyan E, Hoffman EP. Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity. Am J Resp Crit Care Med 2009, 179:467-473. 10.1164/rccm.200807-1085OC, 2654976, 19136373.
29. Sharron M, Hoptay CE, Wiles AA, Garvin LM, Geha M, Benton AS, Nagaraju K, Freishtat RJ. Platelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb/IIIa blockade. PloS one 2012, 7:e41549. 10.1371/journal.pone.0041549, 3406039, 22844498.
30. Vincent JL, Opal SM, Marshall JC. Ten reasons why we should NOT use severity scores as entry criteria for clinical trials or in our treatment decisions. Crit Care Med 2010, 38:283-287. 10.1097/CCM.0b013e3181b785a2, 19730252.