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Volumn 12, Issue 2, 2011, Pages 165-173

Biomarker discovery and development in pediatric critical care medicine

Author keywords

acute kidney injury; biomarker discovery and development; interleukin 8; multibiomarker based risk model; pediatric intensive care unit; pediatric septic shock; procalcitonin

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; CREATINE KINASE; FIBRINOGEN LIKE 2; GRANZYME B; HEAT SHOCK PROTEIN 70; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 8; LACTOFERRIN; LEUKOCYTE ELASTASE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; NEUTROPHIL COLLAGENASE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; OROSOMUCOID; PROCALCITONIN; PROTEIN; RESISTIN; SULFATASE; THROMBOSPONDIN 1; TROPONIN; UNCLASSIFIED DRUG;

EID: 79953087339     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/PCC.0b013e3181e28876     Document Type: Review
Times cited : (88)

References (60)
  • 1
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers Definitions Working Group: Bio-markers and surrogate endpoints: Preferred definitions and conceptual framework
    • Biomarkers Definitions Working Group: Bio-markers and surrogate endpoints: Preferred definitions and conceptual framework. Clin Pharmacol Ther 2001; 69:89-95
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 89-95
  • 3
    • 70349664473 scopus 로고    scopus 로고
    • How-to guide on biomarkers: Biomarker definitions, validation and appli-cations with examples from cardiovascular disease
    • Puntmann VO: How-to guide on biomarkers: Biomarker definitions, validation and appli-cations with examples from cardiovascular disease. Postgrad Med J 2009; 85:538-545
    • (2009) Postgrad Med J , vol.85 , pp. 538-545
    • Puntmann, V.O.1
  • 4
    • 0037078969 scopus 로고    scopus 로고
    • Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events
    • DOI 10.1056/NEJMoa021993
    • Ridker PM, Rifai N, Rose L, et al: Comparison of C-reactive protein and low-density lipo-protein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med 2002; 347:1557-1565 (Pubitemid 35315836)
    • (2002) New England Journal of Medicine , vol.347 , Issue.20 , pp. 1557-1565
    • Ridker, P.M.1    Rifai, N.2    Rose, L.3    Buring, J.E.4    Cook, N.R.5
  • 6
    • 18944371407 scopus 로고    scopus 로고
    • Relative efficacy of atorvastatin 80 mg and pravastatin 40 mg in achieving the dual goals of low-density lipoprotein cholesterol <70 mg/dl and C-reactive protein <2 mg/l: An analysis of the PROVE-IT TIMI-22 trial
    • DOI 10.1016/j.jacc.2005.02.080, PII S0735109705007424
    • Ridker PM, Morrow DA, Rose LM, et al: Rel-ative efficacy of atorvastatin 80 mg and prav-astatin 40 mg in achieving the dual goals of low-density lipoprotein cholesterol <70 mg/dl and C-reactive protein <2 mg/l: an analysis of the PROVE-IT TIMI-22 trial. JAm Coll Cardiol 2005; 45:1644-1648 (Pubitemid 40704500)
    • (2005) Journal of the American College of Cardiology , vol.45 , Issue.10 , pp. 1644-1648
    • Ridker, P.M.1    Morrow, D.A.2    Rose, L.M.3    Rifai, N.4    Cannon, C.P.5    Braunwald, E.6
  • 8
    • 55349099142 scopus 로고    scopus 로고
    • A personalized approach to cancer treatment: How biomarkers can help
    • Duffy MJ, Crown J: A personalized approach to cancer treatment: how biomarkers can help. Clin Chem 2008; 54:1770-1779
    • (2008) Clin Chem , vol.54 , pp. 1770-1779
    • Duffy, M.J.1    Crown, J.2
  • 9
    • 43349108280 scopus 로고    scopus 로고
    • Sepsis: Rethinking the approach to clinical research
    • DOI 10.1189/jlb.0607380
    • Marshall JC: Sepsis: Rethinking the approach to clinical research. J Leukoc Biol 2008; 83: 471-482 (Pubitemid 351966853)
    • (2008) Journal of Leukocyte Biology , vol.83 , Issue.3 , pp. 471-482
    • Marshall, J.C.1
  • 10
    • 33747030845 scopus 로고    scopus 로고
    • Protein biomarker discovery and validation: The long and uncertain path to clinical utility
    • DOI 10.1038/nbt1235, PII NBT1235
    • Rifai N, Gillette MA, Carr SA: Protein bio-marker discovery and validation: The long and uncertain path to clinical utility. Nat Biotechnol 2006; 24:971-983 (Pubitemid 44215392)
    • (2006) Nature Biotechnology , vol.24 , Issue.8 , pp. 971-983
    • Rifai, N.1    Gillette, M.A.2    Carr, S.A.3
  • 11
    • 41649097463 scopus 로고    scopus 로고
    • Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock
    • DOI 10.1097/CCM.0b013e318169245a, PII 0000324620080400000036
    • Wheeler DS, Devarajan P, Ma Q, et al: Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock. Crit Care Med 2008; 36:1297-1303 (Pubitemid 351482681)
    • (2008) Critical Care Medicine , vol.36 , Issue.4 , pp. 1297-1303
    • Wheeler, D.S.1    Devarajan, P.2    Ma, Q.3
  • 16
    • 0029063992 scopus 로고
    • Increased serum nitrite and nitrate concen-trations in children with the sepsis syn-drome
    • Wong HR, Carcillo JA, Burckart G, et al: Increased serum nitrite and nitrate concen-trations in children with the sepsis syn-drome. Crit Care Med 1995; 23:835-842
    • (1995) Crit Care Med , vol.23 , pp. 835-842
    • Wong, H.R.1    Carcillo, J.A.2    Burckart, G.3
  • 17
    • 0001644020 scopus 로고    scopus 로고
    • The human plasma proteome: History character and di-agnostic prospects
    • Anderson NL, Anderson NG: The human plasma proteome: history, character, and di-agnostic prospects. Mol Cell Proteomics 2002; 1:845-867
    • (2002) Mol Cell Proteomics , vol.1 , pp. 845-867
    • Anderson, N.L.1    Anderson, N.G.2
  • 18
    • 70449637194 scopus 로고    scopus 로고
    • Ac-curacy of neutrophil gelatinase-associated li-pocalin (NGAL) in diagnosis and prognosis in acute kidney injury: A systematic review and meta-analysis
    • Haase M, Bellomo R, Devarajan P, et al: Ac-curacy of neutrophil gelatinase-associated li-pocalin (NGAL) in diagnosis and prognosis in acute kidney injury: A systematic review and meta-analysis. Am J Kidney Dis 2009; 54: 1012-1024
    • (2009) Am J Kidney Dis , vol.54 , pp. 1012-1024
    • Haase, M.1    Bellomo, R.2    Devarajan, P.3
  • 19
    • 45849106452 scopus 로고    scopus 로고
    • Neutrophil gelatinase-associated lipocalin (NGAL): A new marker of kidney disease
    • DOI 10.1080/00365510802150158, PII 794009082
    • Devarajan P: Neutrophil gelatinase-associ-ated lipocalin (NGAL): A new marker of kid-ney disease. Scand J Clin Lab Invest Suppl 2008; 241:89-94 (Pubitemid 351883665)
    • (2008) Scandinavian Journal of Clinical and Laboratory Investigation , vol.68 , Issue.SUPPL. 241 , pp. 89-94
    • Devarajan, P.1
  • 20
    • 20144388328 scopus 로고    scopus 로고
    • Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery
    • DOI 10.1016/S0140-6736(05)74811-X
    • Mishra J, Dent C, Tarabishi R, et al: Neutro-phil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 2005; 365: 1231-1238 (Pubitemid 40469655)
    • (2005) Lancet , vol.365 , Issue.9466 , pp. 1231-1238
    • Mishra, J.1    Dent, C.2    Tarabishi, R.3
  • 22
    • 36549025838 scopus 로고    scopus 로고
    • Proteomics for Biomarker Discovery in Acute Kidney Injury
    • DOI 10.1016/j.semnephrol.2007.09.005, PII S0270929507001295, Proteomics and the Kidney
    • Devarajan P: Proteomics for biomarker dis-covery in acute kidney injury. Semin Neph-rol 2007; 27:637-651 (Pubitemid 350180173)
    • (2007) Seminars in Nephrology , vol.27 , Issue.6 , pp. 637-651
    • Devarajan, P.1
  • 23
    • 0031302675 scopus 로고    scopus 로고
    • Procalcitonin and its component peptides in systemic inflammation: Immunochemical characterization
    • Snider RH Jr, Nylen ES, Becker KL: Procal-citonin and its component peptides in sys-temic inflammation: Immunochemical char-acterization. J Investig Med 1997; 45: 552-560 (Pubitemid 127806489)
    • (1997) Journal of Investigative Medicine , vol.45 , Issue.9 , pp. 552-560
    • Snider Jr., R.H.1    Nylen, E.S.2    Becker, K.L.3
  • 24
    • 75649119976 scopus 로고    scopus 로고
    • Procalci-tonin in sepsis and systemic inflammation: A harmful biomarker and a therapeutic target
    • Becker KL, Snider R, Nylen ES: Procalci-tonin in sepsis and systemic inflammation: A harmful biomarker and a therapeutic target. Br J Pharmacol 2010; 159:253-264
    • (2010) Br J Pharmacol , vol.159 , pp. 253-264
    • Becker, K.L.1    Snider, R.2    Nylen, E.S.3
  • 25
    • 0027466275 scopus 로고
    • High serum procalcitonin concentrations in patients with sepsis and infection
    • DOI 10.1016/0140-6736(93)90277-N
    • Assicot M, Gendrel D, Carsin H, et al: High serum procalcitonin concentrations in pa-tients with sepsis and infection. Lancet 1993; 341:515-518 (Pubitemid 23066085)
    • (1993) Lancet , vol.341 , Issue.8844 , pp. 515-518
    • Assicot, M.1    Gendrel, D.2    Carsin, H.3    Raymond, J.4    Guilbaud, J.5    Bohuon, C.6
  • 26
    • 0344825792 scopus 로고    scopus 로고
    • In vitro and in vivo calcitonin I gene expression in parenchymal cells: A novel product of hu-man adipose tissue
    • DOI 10.1210/en.2003-0854
    • Linscheid P, Seboek D, Nylen ES, et al: In vitro and in vivo calcitonin I gene expression in parenchymal cells: A novel product of hu-man adipose tissue. Endocrinology 2003; 144:5578-5584 (Pubitemid 37476087)
    • (2003) Endocrinology , vol.144 , Issue.12 , pp. 5578-5584
    • Linscheid, P.1    Seboek, D.2    Nylen, E.S.3    Langer, I.4    Schlatter, M.5    Becker, K.L.6    Keller, U.7    Muller, B.8
  • 28
    • 0028575739 scopus 로고
    • Procal-citonin increase after endotoxin injection in normal subjects
    • Dandona P, Nix D, Wilson MF, et al: Procal-citonin increase after endotoxin injection in normal subjects. J Clin Endocrinol Metab 1994; 79:1605-1608
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 1605-1608
    • Dandona, P.1    Nix, D.2    Wilson, M.F.3
  • 29
    • 0032734656 scopus 로고    scopus 로고
    • Discrimination of infectious and noninfectious causes of early acute respiratory distress syndrome by procalcitonin
    • DOI 10.1097/00003246-199910000-00016
    • Brunkhorst FM, Eberhard OK, Brunkhorst R: Discrimination of infectious and noninfec-tious causes of early acute respiratory dis-tress syndrome by procalcitonin. Crit Care Med 1999; 27:2172-2176 (Pubitemid 29508332)
    • (1999) Critical Care Medicine , vol.27 , Issue.10 , pp. 2172-2176
    • Brunkhorst, F.M.1    Eberhard, O.K.2    Brunkhorst, R.3
  • 30
    • 33745622134 scopus 로고    scopus 로고
    • Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: A systematic review and meta-analysis
    • DOI 10.1097/01.CCM.0000226413.54364.36, PII 0000324620060700000020
    • Uzzan B, Cohen R, Nicolas P, et al: Procalci-tonin as a diagnostic test for sepsis in criti-cally ill adults and after surgery or trauma: A systematic review and meta-analysis. Crit Care Med 2006; 34:1996-2003 (Pubitemid 43982479)
    • (2006) Critical Care Medicine , vol.34 , Issue.7 , pp. 1996-2003
    • Uzzan, B.1    Cohen, R.2    Nicolas, P.3    Cucherat, M.4    Perret, G.-Y.5
  • 31
    • 68849105631 scopus 로고    scopus 로고
    • Procal-citonin versus C-reactive protein and imma-ture-to-total neutrophil ratio as markers of infection after cardiopulmonary bypass in children
    • McMaster P, Park DY, Shann F, et al: Procal-citonin versus C-reactive protein and imma-ture-to-total neutrophil ratio as markers of infection after cardiopulmonary bypass in children. Pediatr Crit Care Med 2009; 10: 217-221
    • (2009) Pediatr Crit Care Med , vol.10 , pp. 217-221
    • McMaster, P.1    Park, D.Y.2    Shann, F.3
  • 32
    • 61749083263 scopus 로고    scopus 로고
    • Procalcitonin and C-reactive protein as markers of bacterial infection in critically ill children at onset of systemic inflammatory response syndrome
    • Simon L, Saint-Louis P, Amre DK, et al: Procalcitonin and C-reactive protein as markers of bacterial infection in critically ill children at onset of systemic inflammatory response syndrome. Pediatr Crit Care Med 2008; 9:407-413
    • (2008) Pediatr Crit Care Med , vol.9 , pp. 407-413
    • Simon, L.1    Saint-Louis, P.2    Amre, D.K.3
  • 33
    • 3242810355 scopus 로고    scopus 로고
    • Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: A systematic review and meta-analysis
    • DOI 10.1086/421997
    • Simon L, Gauvin F, Amre DK, et al: Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: A systematic review and meta-analysis. Clin Infect Dis 2004; 39:206-217 (Pubitemid 38971491)
    • (2004) Clinical Infectious Diseases , vol.39 , Issue.2 , pp. 206-217
    • Simon, L.1    Gauvin, F.2    Amre, D.K.3    Saint-Louis, P.4    Lacroix, J.5
  • 34
    • 66449093196 scopus 로고    scopus 로고
    • Procal-citonin as a prognostic and diagnostic tool for septic complications after major trauma
    • Castelli GP, Pognani C, Cita M, et al: Procal-citonin as a prognostic and diagnostic tool for septic complications after major trauma. Crit Care Med 2009; 37:1845-1849
    • (2009) Crit Care Med , vol.37 , pp. 1845-1849
    • Castelli, G.P.1    Pognani, C.2    Cita, M.3
  • 35
    • 33847056146 scopus 로고    scopus 로고
    • Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: Systematic review and meta-analysis
    • DOI 10.1016/S1473-3099(07)70052-X, PII S147330990770052X
    • Tang BM, Eslick GD, Craig JC, et al: Accuracy of procalcitonin for sepsis diagnosis in criti-cally ill patients: Systematic review and meta-analysis. Lancet Infect Dis 2007; 7:210-217 (Pubitemid 46274517)
    • (2007) Lancet Infectious Diseases , vol.7 , Issue.3 , pp. 210-217
    • Tang, B.M.1    Eslick, G.D.2    Craig, J.C.3    McLean, A.S.4
  • 36
    • 74949084200 scopus 로고    scopus 로고
    • Additional value of procalcitonin for diagno-sis of infection in patients with fever at the emergency department
    • de Kruif MD, Limper M, Gerritsen H, et al: Additional value of procalcitonin for diagno-sis of infection in patients with fever at the emergency department. Crit Care Med 2010; 38:457-463
    • (2010) Crit Care Med , vol.38 , pp. 457-463
    • De Kruif, M.D.1    Limper, M.2    Gerritsen, H.3
  • 37
    • 33847376418 scopus 로고    scopus 로고
    • Procalcitonin and C-reactive protein as markers of systemic inflammatory response syndrome severity in critically ill children
    • DOI 10.1007/s00134-006-0509-7
    • Rey C, Los Arcos M, Concha A, et al: Procal-citonin and C-reactive protein as markers of systemic inflammatory response syndrome severity in critically ill children. Intensive Care Med 2007; 33:477-484 (Pubitemid 46333842)
    • (2007) Intensive Care Medicine , vol.33 , Issue.3 , pp. 477-484
    • Rey, C.1    Los Arcos, M.2    Concha, A.3    Medina, A.4    Prieto, S.5    Martinez, P.6    Prieto, B.7
  • 38
    • 0035091764 scopus 로고    scopus 로고
    • Comparison of procalcitonin with C-reactive protein and serum amyloid for the early diagnosis of bacterial sepsis in critically ill neonates and children
    • DOI 10.1007/s001340000709
    • Enguix A, Rey C, Concha A, et al: Compari-son of procalcitonin with C-reactive protein and serum amyloid for the early diagnosis of bacterial sepsis in critically ill neonates and children. Intensive Care Med 2001; 27: 211-215 (Pubitemid 32208990)
    • (2001) Intensive Care Medicine , vol.27 , Issue.1 , pp. 211-215
    • Enguix, A.1    Rey, C.2    Concha, A.3    Medina, A.4    Coto, D.5    Dieguez, M.A.6
  • 39
    • 67649678797 scopus 로고    scopus 로고
    • Markers that predict serious bacterial infec-tion in infants under 3 months of age pre-senting with fever of unknown origin
    • Olaciregui I, Hernandez U, Munoz JA, et al: Markers that predict serious bacterial infec-tion in infants under 3 months of age pre-senting with fever of unknown origin. Arch Dis Child 2009; 94:501-505
    • (2009) Arch Dis Child , vol.94 , pp. 501-505
    • Olaciregui, I.1    Hernandez, U.2    Munoz, J.A.3
  • 40
    • 85047687279 scopus 로고    scopus 로고
    • Procal-citonin is persistently increased among chil-dren with poor outcome from bacterial sep-sis
    • Han YY, Doughty LA, Kofos D, et al: Procal-citonin is persistently increased among chil-dren with poor outcome from bacterial sep-sis. Pediatr Crit Care Med 2003; 4:21-25
    • (2003) Pediatr Crit Care Med , vol.4 , pp. 21-25
    • Han, Y.Y.1    Doughty, L.A.2    Kofos, D.3
  • 41
    • 67650917117 scopus 로고    scopus 로고
    • Procalcitonin to guide duration of antibiotic therapy in intensive care patients: A randomized prospective controlled trial
    • Hochreiter M, Kohler T, Schweiger AM, et al: Procalcitonin to guide duration of antibiotic therapy in intensive care patients: A random-ized prospective controlled trial. Crit Care 2009; 13:R83
    • (2009) Crit Care , vol.13
    • Hochreiter, M.1    Kohler, T.2    Schweiger, A.M.3
  • 42
    • 70149088214 scopus 로고    scopus 로고
    • Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: The Pro-HOSP randomized controlled trial
    • Schuetz P, Christ-Crain M, Thomann R, et al: Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: The Pro-HOSP randomized controlled trial. JAMA 2009; 302:1059-1066
    • (2009) JAMA , vol.302 , pp. 1059-1066
    • Schuetz, P.1    Christ-Crain, M.2    Thomann, R.3
  • 43
    • 75949113583 scopus 로고    scopus 로고
    • Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): A multicentre randomised controlled trial
    • Bouadma L, Luyt CE, Tubach F, et al: Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): A multicentre randomised controlled trial. Lancet 2010; 375:463-474
    • (2010) Lancet , vol.375 , pp. 463-474
    • Bouadma, L.1    Luyt, C.E.2    Tubach, F.3
  • 44
    • 33645817748 scopus 로고    scopus 로고
    • Interleukin-18: A novel prognostic cytokine in bacteria-induced sepsis
    • Tschoeke SK, Oberholzer A, Moldawer LL: Interleukin-18: A novel prognostic cytokine in bacteria-induced sepsis. Crit Care Med 2006; 34:1225-1233
    • (2006) Crit Care Med , vol.34 , pp. 1225-1233
    • Tschoeke, S.K.1    Oberholzer, A.2    Moldawer, L.L.3
  • 45
    • 77950308486 scopus 로고    scopus 로고
    • Synovial tissue and serum biomarkers of dis-ease activity, therapeutic response and radio-graphic progression: Analysis of a proof-of-concept randomised clinical trial of cytokine blockade
    • Rooney T, Roux-Lombard P, Veale DJ, et al: Synovial tissue and serum biomarkers of dis-ease activity, therapeutic response and radio-graphic progression: Analysis of a proof-of-concept randomised clinical trial of cytokine blockade. Ann Rheum Dis 2010; 69:706-714
    • (2010) Ann Rheum Dis , vol.69 , pp. 706-714
    • Rooney, T.1    Roux-Lombard, P.2    Veale, D.J.3
  • 47
  • 48
    • 0035653851 scopus 로고    scopus 로고
    • Interleukin-18 plasma levels are increased in patients with sepsis compared to severely injured patients
    • Oberholzer A, Steckholzer U, Kurimoto M, et al: Interleukin-18 plasma levels are increased in patients with sepsis compared to severely injured patients. Shock 2001; 16:411-414 (Pubitemid 33598220)
    • (2001) Shock , vol.16 , Issue.6 , pp. 411-414
    • Oberholzer, A.1    Steckholzer, U.2    Kurimoto, M.3    Trentz, O.4    Ertel, W.5
  • 49
    • 0036781109 scopus 로고    scopus 로고
    • Differential regulation of systemic IL-18 and IL-12 release during postoperative sepsis: High serum IL-18 as an early predic-tive indicator of lethal outcome
    • Emmanuilidis K, Weighardt H, Matevossian E, et al: Differential regulation of systemic IL-18 and IL-12 release during postoperative sepsis: high serum IL-18 as an early predic-tive indicator of lethal outcome. Shock 2002; 18:301-305
    • (2002) Shock , vol.18 , pp. 301-305
    • Emmanuilidis, K.1    Weighardt, H.2    Matevossian, E.3
  • 51
    • 41649095757 scopus 로고    scopus 로고
    • New biomarkers of acute kidney injury
    • DOI 10.1097/CCM.0b013e318168c652, PII 0000324620080400100004
    • Parikh CR, Devarajan P: New biomarkers of acute kidney injury. Crit Care Med 2008; 36(4 Suppl):S159-S165 (Pubitemid 351483046)
    • (2008) Critical Care Medicine , vol.36 , Issue.SUPPL. 4
    • Parikh, C.R.1    Devarajan, P.2
  • 52
    • 33745725903 scopus 로고    scopus 로고
    • Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery
    • DOI 10.1038/sj.ki.5001527, PII 5001527
    • Parikh CR, Mishra J, Thiessen-Philbrook H, et al: Urinary IL-18 is an early predictive biomarker of acute kidney injury after car-diac surgery. Kidney Int 2006; 70:199-203 (Pubitemid 44000139)
    • (2006) Kidney International , vol.70 , Issue.1 , pp. 199-203
    • Parikh, C.R.1    Mishra, J.2    Thiessen-Philbrook, H.3
  • 54
    • 48249148704 scopus 로고    scopus 로고
    • Interleukin-8 as a stratification tool for in-terventional trials involving pediatric septic shock
    • Wong HR, Cvijanovich N, Wheeler DS, et al: Interleukin-8 as a stratification tool for in-terventional trials involving pediatric septic shock. Am J Respir Crit Care Med 2008; 178:276-282
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 276-282
    • Wong, H.R.1    Cvijanovich, N.2    Wheeler, D.S.3
  • 57
    • 77949454402 scopus 로고    scopus 로고
    • Admission chemokine (C-C motif) ligand 4 levels predict survival in pediatric septic shock
    • Nowak JE, Wheeler DS, Harmon KK, et al: Admission chemokine (C-C motif) ligand 4 levels predict survival in pediatric septic shock Pediatr Crit Care Med 2010; 11:213-216
    • (2010) Pediatr Crit Care Med , vol.11 , pp. 213-216
    • Nowak, J.E.1    Wheeler, D.S.2    Harmon, K.K.3
  • 58
    • 70349239233 scopus 로고    scopus 로고
    • Iden-tification of pediatric septic shock subclasses based on genome-wide expression profiling
    • Wong HR, Cvijanovich N, Lin R, et al: Iden-tification of pediatric septic shock subclasses based on genome-wide expression profiling. BMC Med 2009; 7:34
    • (2009) BMC Med , vol.7 , pp. 34
    • Wong, H.R.1    Cvijanovich, N.2    Lin, R.3
  • 59
    • 0345040882 scopus 로고    scopus 로고
    • Support vector machine applications in bioinformatics
    • Byvatov E, Schneider G: Support vector machine applications in bioinformatics. Appl Bioinformatics 2003; 2:67-77
    • (2003) Appl Bioinformatics , vol.2 , pp. 67-77
    • Byvatov, E.1    Schneider, G.2
  • 60
    • 74049085767 scopus 로고    scopus 로고
    • Ten reasons why we should NOT use severity scores as entry criteria for clinical trials or in our treatment decisions
    • Vincent JL, Opal SM, Marshall JC: Ten reasons why we should NOT use severity scores as entry criteria for clinical trials or in our treatment decisions. Crit Care Med 38:283-287
    • Crit Care Med , vol.38 , pp. 283-287
    • Vincent, J.L.1    Opal, S.M.2    Marshall, J.C.3


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