Different oxysterols have opposing actions at N-methyl-d-aspartate receptors

Neuropharmacology

Volumn 85, Issue , 2014, Pages 232-242

  Linsenbardt, Andrew J ^a   Taylor, Amanda ^a   Emnett, Christine M ^a   Doherty, James J ^b   Krishnan, Kathiresan ^a   Covey, Douglas F ^a   Paul, Steven M ^b,c   Zorumski, Charles F ^a   Mennerick, Steven ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Sage Therapeutics Inc   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Allosteric; Gating; Modulation; Neurodegeneration; NMDA receptor

Indexed keywords

24 HYDROXYCHOLESTEROL; 4 AMINOBUTYRIC ACID A RECEPTOR; ION CHANNEL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; OXYSTEROL; PREGNENOLONE SULFATE; SGE 201; UNCLASSIFIED DRUG; 24-HYDROXYCHOLESTEROL; 25-HYDROXYCHOLESTEROL; AMINO ACID RECEPTOR AFFECTING AGENT; AMINO ACID RECEPTOR STIMULATING AGENT; CHOLESTEROL DERIVATIVE; DIZOCILPINE MALEATE;

ALLOSTERISM; ANIMAL EXPERIMENT; ARTICLE; CELL MEMBRANE; CHANNEL GATING; CONTROLLED STUDY; DRUG MECHANISM; ENANTIOSELECTIVITY; FEMALE; MALE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; CELL CULTURE; CYTOSOL; DOSE RESPONSE; DRUG EFFECTS; HIPPOCAMPUS; KINETICS; MEMBRANE POTENTIAL; METABOLISM; NERVE CELL; OOCYTE; PATCH CLAMP TECHNIQUE; PHYSIOLOGY; SPRAGUE DAWLEY RAT; XENOPUS LAEVIS;

ANIMALS; CELL MEMBRANE; CELLS, CULTURED; CYTOSOL; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGENTS; EXCITATORY AMINO ACID AGONISTS; FEMALE; HIPPOCAMPUS; HYDROXYCHOLESTEROLS; KINETICS; MALE; MEMBRANE POTENTIALS; NEURONS; OOCYTES; PATCH-CLAMP TECHNIQUES; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; XENOPUS LAEVIS;

EID: 84902492052     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.05.027     Document Type: Article

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