The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-Methyl-D-Aspartate receptors

Journal of Neuroscience

Volumn 33, Issue 44, 2013, Pages 17290-17300

  Paul, Steven M ^a,b   Doherty, James J ^a   Robichaud, Albert J ^a   Belfort, Gabriel M ^a   Chow, Brian Y ^a   Hammond, Rebecca S ^a   Crawford, Devon C ^c   Linsenbardt, Andrew J ^c   Shu, Hong Jin ^c   Izumi, Yukitoshi ^c   Mennerick, Steven J ^c   Zorumski, Charles F ^c  

^a Sage Therapeutics Inc   (United States)

^b FEIL FAMILY BRAIN AND MIND RESEARCH INSTITUTE   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

24 HYDROXYCHOLESTEROL; CHOLESTEROL DERIVATIVE; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OXYSTEROL; RECOMBINANT RECEPTOR; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; HUMAN; HUMAN CELL; INHIBITORY POSTSYNAPTIC POTENTIAL; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LONG TERM POTENTIATION; MALE; MASS SPECTROMETRY; MOUSE; NERVE CELL PLASTICITY; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SCHIZOPHRENIA; SOCIAL INTERACTION;

ACTION POTENTIALS; ALLOSTERIC REGULATION; ANIMALS; CHOLESTEROL; FEMALE; HIPPOCAMPUS; HYDROXYCHOLESTEROLS; MALE; MICE; ORGAN CULTURE TECHNIQUES; RATS; RATS, LONG-EVANS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84886690869     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2619-13.2013     Document Type: Article

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