Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials

Journal of Medicinal Chemistry

Volumn 57, Issue 11, 2014, Pages 4916-4923

  Oliveira, Rudi ^a   Guedes, Rita C ^a   Meireles, Patrícia ^b   Albuquerque, Inês S ^b   Gonçalves, Lídia M ^a   Pires, Elisabete ^c   Bronze, Maria Rosário ^a,c   Gut, Jiri ^d   Rosenthal, Philip J ^d   Prudêncio, Miguel ^b   Moreira, Rui ^a   O'Neill, Paul M ^e   Lopes, Francisca ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^c Estacao Agronomica Nacional   (Portugal)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISININ; CHLOROQUINE; PYRIMIDINE DERIVATIVE; TETRAOXANE DERIVATIVE;

ARTICLE; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; PARASITEMIA; PLASMODIUM; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; CELL LINE; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; HUMANS; MALARIA; MICE, INBRED C57BL; MOLECULAR DOCKING SIMULATION; NITRILES; OXIDATIVE STRESS; PEPTIDOMIMETICS; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAOXANES;

EID: 84902449185     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5004528     Document Type: Article

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