Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 43, 2009, Pages 18285-18290

  Mörck, Catarina ^a   Olsen, Louise ^b   Kurth, Caroline ^c   Persson, Annelie ^a   Storm, Nadia Jin ^b   Svensson, Emma ^a   Jansson, John Olov ^a   Hellqvist, Marika ^a   Enejder, Annika ^c   Faergeman, Nils J ^b   Pilon, Marc ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

HMG CoA reductase; Small GTPase; Unfolded protein response (UPR)

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; DYE; FLUINDOSTATIN; GREEN FLUORESCENT PROTEIN; GUANOSINE TRIPHOSPHATASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID; LIPID; MEVALONIC ACID; NUCLEIC ACID BINDING PROTEIN; PEK 1 PROTEIN; PROTEIN FARNESYLTRANSFERASE; PROTEIN IRE1; STEROL; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ARTICLE; CAENORHABDITIS ELEGANS; CELL STRESS; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; ENZYME SUBSTRATE; GROWTH INHIBITION; LARVAL DEVELOPMENT; LIPID COMPOSITION; LIPID STORAGE; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN INDUCTION; PROTEIN LIPIDATION; PROTEIN MODIFICATION; PROTEIN PRENYLATION; RNA INTERFERENCE; STAINING; UPREGULATION; WORM;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; GERANYLTRANSTRANSFERASE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LARVA; LIPID METABOLISM; LIPOPROTEINS; PHENOTYPE; PROTEIN FOLDING; PROTEIN PRENYLATION; RNA INTERFERENCE; SUBSTRATE SPECIFICITY;

CAENORHABDITIS ELEGANS;

EID: 70849108761     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0907117106     Document Type: Article

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