Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Spindler, Stephen R ^a   Li, Rui ^a   Dhahbi, Joseph M ^a   Yamakawa, Amy ^a   Mote, Patricia ^a   Bodmer, Rolf ^b   Ocorr, Karen ^b   Williams, Renee T ^c   Wang, Yinsheng ^c   Ablao, Kenneth P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BURNHAM INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[2 [[2 [(2 AMINO 3 MERCAPTOPROPYL)AMINO] 3 METHYLPENTYL]OXY] 1 OXO 3 PHENYLPROPYL]AMINO] 4 (METHYLSULFONYL)BUTANOIC ACID ISOPROPYL ESTER; GGTI 298; JUVENILE HORMONE; METHOPRENE; RAS PROTEIN; SIMVASTATIN; UBIQUINONE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; HEART ARRHYTHMIA; HEART CONTRACTION; HEART FUNCTION; HEART MUSCLE RELAXATION; LIFE EXTENSION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PRENYLATION;

AGING; ANIMALS; BEHAVIOR, ANIMAL; BENZAMIDES; CARDIOVASCULAR DISEASES; DROSOPHILA MELANOGASTER; FEEDING BEHAVIOR; HEART; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LONGEVITY; MALE; METHIONINE; MICE; SIMVASTATIN; UBIQUINONE;

EID: 84862657169     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039581     Document Type: Article

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