CMZ reversed chronic ethanol-induced disturbance of PPAR-α possibly by suppressing oxidative stress and PGC-1α acetylation, and activating the MAPK and GSK3β pathway

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Zeng, Tao ^a   Zhang, Cui Li ^a   Song, Fu Yong ^a   Zhao, Xiu Lan ^a   Xie, Ke Qin ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A CARBOXYLASE; CARBOXYLASE; CLOMETHIAZOLE; FATTY ACID SYNTHASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RETINOID X RECEPTOR ALPHA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ALCOHOL; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; PPARGC1A PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ACC ALPHA GENE; ACETYLATION; ALCOHOLIC FATTY LIVER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEACETYLATION; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; FAS GENE; GENE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PGC 1ALPHA GENE; POLYMERASE CHAIN REACTION; PPAR ALPHA GENE; SIGNAL TRANSDUCTION; SREBP 1 GENE; TRIACYLGLYCEROL BLOOD LEVEL; WESTERN BLOTTING; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; FATTY LIVER; LIVER; METABOLISM; PATHOLOGY; TOXICITY;

ACETYLATION; ANIMALS; CHLORMETHIAZOLE; ETHANOL; FATTY LIVER; GLYCOGEN SYNTHASE KINASE 3; LIVER; MALE; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; OXIDATIVE STRESS; PPAR ALPHA; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84902440622     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0098658     Document Type: Article

References (55)

1. Ramaiah S, Rivera C, Arteel G (2004) Early-phase alcoholic liver disease: an update on animal models, pathology, and pathogenesis. Int J Toxicol 23: 217-231. (Pubitemid 39346621)
2. O'Shea RS, Dasarathy S, McCullough AJ (2010) Alcoholic liver disease. Hepatology 51: 307-328.
3. Day CP, James OF (1998) Hepatic steatosis: innocent bystander or guilty party? Hepatology 27: 1463-1466. (Pubitemid 28264666)
4. Crabb DW (1999) Pathogenesis of alcoholic liver disease: newer mechanisms of injury. Keio J Med 48: 184-188.
5. Lieber CS, Jones DP, Decarli LM (1965) Effects of Prolonged Ethanol Intake: Production of Fatty Liver Despite Adequate Diets. J Clin Invest 44: 1009-1021.
6. Leevy CM (1962) Fatty liver: a study of 270 patients with biopsy proven fatty liver and review of the literature. Medicine (Baltimore) 41: 249-276.
7. Sorensen TI, Orholm M, Bentsen KD, Hoybye G, Eghoje K, et al. (1984) Prospective evaluation of alcohol abuse and alcoholic liver injury in men as predictors of development of cirrhosis. Lancet 2: 241-244. (Pubitemid 14057074)
8. Zeng T, Zhang CL, Song FY, Zhao XL, Xie KQ (2012) Garlic oil alleviated ethanol-induced fat accumulation via modulation of SREBP-1, PPAR-alpha, and CYP2E1. Food Chem Toxicol 50: 485-491.
9. Gyamfi MA, Wan YJ (2010) Pathogenesis of alcoholic liver disease: the role of nuclear receptors. Exp Biol Med (Maywood) 235: 547-560.
10. Purohit V, Gao B, Song BJ (2009) Molecular mechanisms of alcoholic fatty liver. Alcohol Clin Exp Res 33: 191-205.
11. Donohue TM Jr (2007) Alcohol-induced steatosis in liver cells. World J Gastroenterol 13: 4974-4978.
12. Cederbaum AI (2010) Role of CYP2E1 in ethanol-induced oxidant stress, fatty liver and hepatotoxicity. Dig Dis 28: 802-811.
13. Leung TM, Nieto N (2013) CYP2E1 and oxidant stress in alcoholic and nonalcoholic fatty liver disease. J Hepatol 58: 395-398.
14. Reinke LA, Lai EK, DuBose CM, McCay PB (1987) Reactive free radical generation in vivo in heart and liver of ethanol-fed rats: correlation with radical formation in vitro. Proc Natl Acad Sci U S A 84: 9223-9227.
15. Lu Y, Zhuge J, Wang X, Bai J, Cederbaum AI (2008) Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology 47: 1483-1494. (Pubitemid 351702732)
16. Wan YY, Cai Y, Li J, Yuan Q, French B, et al. (2001) Regulation of peroxisome proliferator activated receptor alpha-mediated pathways in alcohol fed cytochrome P450 2E1 deficient mice. Hepatol Res 19: 117-130. (Pubitemid 32097937)
17. Kono H, Bradford BU, Yin M, Sulik KK, Koop DR, et al. (1999) CYP2E1 is not involved in early alcohol-induced liver injury. Am J Physiol 277: G1259-1267. (Pubitemid 30046029)
18. You M, Crabb DW (2004) Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteins. Alcohol 34: 39-43.
19. Zhao Z, Yu M, Crabb D, Xu Y, Liangpunsakul S (2011) Ethanol-induced alterations in fatty acid-related lipids in serum and tissues in mice. Alcohol Clin Exp Res 35: 229-234.
20. Nakajima T, Kamijo Y, Tanaka N, Sugiyama E, Tanaka E, et al. (2004) Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage. Hepatology 40: 972-980. (Pubitemid 39288131)
21. Crabb DW, Galli A, Fischer M, You M (2004) Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha. Alcohol 34: 35-38.
22. Zeng T, Xie KQ (2009) Ethanol and liver: recent advances in the mechanisms of ethanol-induced hepatosteatosis. Arch Toxicol 83: 1075-1081.
23. Ding WX, Manley S, Ni HM (2011) The emerging role of autophagy in alcoholic liver disease. Exp Biol Med (Maywood) 236: 546-556.
24. You M, Fischer M, Deeg MA, Crabb DW (2002) Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). J Biol Chem 277: 29342-29347.
25. Ajmo JM, Liang X, Rogers CQ, Pennock B, You M (2008) Resveratrol alleviates alcoholic fatty liver in mice. Am J Physiol Gastrointest Liver Physiol 295: G833-842.
26. Yin HQ, Kim M, Kim JH, Kong G, Kang KS, et al. (2007) Differential gene expression and lipid metabolism in fatty liver induced by acute ethanol treatment in mice. Toxicol Appl Pharmacol 223: 225-233. (Pubitemid 47371140)
27. Ji C, Chan C, Kaplowitz N (2006) Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model. J Hepatol 45: 717-724. (Pubitemid 44479875)
28. Ding WX, Li M, Chen X, Ni HM, Lin CW, et al. (2010) Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice. Gastroenterology 139: 1740-1752.
29. Eid N, Ito Y, Maemura K, Otsuki Y (2013) Elevated autophagic sequestration of mitochondria and lipid droplets in steatotic hepatocytes of chronic ethanol-treated rats: an immunohistochemical and electron microscopic study. J Mol Histol 44: 311-326.
30. Lieber CS, DeCarli LM, Sorrell MF (1989) Experimental methods of ethanol administration. Hepatology 10: 501-510. (Pubitemid 19255473)
31. Zeng T, Zhang CL, Song FY, Zhao XL, Yu LH, et al. (2013) The activation of HO-1/Nrf-2 contributes to the protective effects of diallyl disulfide (DADS) against ethanol-induced oxidative stress. Biochim Biophys Acta 1830: 4848-4859.
32. Zeng T, Zhang CL, Song FY, Han XY, Xie KQ (2009) The modulatory effects of garlic oil on hepatic cytochrome P450s in mice. Hum Exp Toxicol 28: 777-783.
33. Pahan K, Smith BT, Singh AK, Singh I (1997) Cytochrome P-450 2E1 in rat liver peroxisomes: downregulation by ischemia/reperfusion-induced oxidative stress. Free Radic Biol Med 23: 963-971. (Pubitemid 27451282)
34. Zeng T, Zhang CL, Song FY, Zhao XL, Yu LH, et al. (2012) PI3K/Akt pathway activation was involved in acute ethanol-induced fatty liver in mice. Toxicology 296: 56-66.
35. Shen Z, Liang X, Rogers CQ, Rideout D, You M (2009) Involvement of Adiponectin-SIRT1-AMPK Signaling in the Protective Action of Rosiglitazone against Alcoholic Fatty Liver in Mice. Am J Physiol Gastrointest Liver Physiol.
36. Sertznig P, Seifert M, Tilgen W, Reichrath J (2008) Peroxisome proliferator-activated receptors (PPARs) and the human skin: importance of PPARs in skin physiology and dermatologic diseases. Am J Clin Dermatol 9: 15-31. (Pubitemid 351993189)
37. Medina J, Moreno-Otero R (2005) Pathophysiological basis for antioxidant therapy in chronic liver disease. Drugs 65: 2445-2461. (Pubitemid 41697314)
38. Albano E (2008) Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol Aspects Med 29: 9-16.
39. Zhou Z, Wang L, Song Z, Lambert JC, McClain CJ, et al. (2003) A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-alpha production. Am J Pathol 163: 1137-1146. (Pubitemid 37040149)
40. Beier K, Volkl A, Fahimi HD (1997) TNF-alpha downregulates the peroxisome proliferator activated receptor-alpha and the mRNAs encoding peroxisomal proteins in rat liver. FEBS Lett 412: 385-387. (Pubitemid 27321288)
41. You M, Crabb DW (2004) Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver. Am J Physiol Gastrointest Liver Physiol 287: G1-6. (Pubitemid 38802112)
42. Burns KA, Vanden Heuvel JP (2007) Modulation of PPAR activity via phosphorylation. Biochim Biophys Acta 1771: 952-960. (Pubitemid 47198547)
43. Ogita S, Lorusso P (2011) Targeting phosphatidylinositol 3 kinase (PI3K)-Akt beyond rapalogs. Target Oncol 6: 103-117.
44. Simpson KJ, Venkatesan S, Peters TJ (1994) Fatty acid synthesis by rat liver after chronic ethanol feeding with a low-fat diet. Clin Sci (Lond) 87: 441-446. (Pubitemid 24323937)
45. Ki SH, Choi JH, Kim CW, Kim SG (2007) Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity. Chem Biol Interact 169: 80-90. (Pubitemid 47125870)
46. He L, Marecki JC, Serrero G, Simmen FA, Ronis MJ, et al. (2007) Dose-dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health. Mol Endocrinol 21: 2541-2550. (Pubitemid 47529364)
47. Mizushima N (2004) Methods for monitoring autophagy. Int J Biochem Cell Biol 36: 2491-2502.
48. Bjorkoy G, Lamark T, Pankiv S, Overvatn A, Brech A, et al. (2009) Monitoring autophagic degradation of p62/SQSTM1. Methods Enzymol 452: 181-197.
49. Kong L, Ren W, Li W, Zhao S, Mi H, et al. (2011) Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol induced steatohepatitis in mice. Lipids Health Dis 10: 246.
50. Kang X, Zhong W, Liu J, Song Z, McClain CJ, et al. (2009) Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha. Hepatology 50: 1241-1250.
51. Zhu H, Jia Z, Misra H, Li YR (2012) Oxidative stress and redox signaling mechanisms of alcoholic liver disease: updated experimental and clinical evidence. J Dig Dis 13: 133-142.
52. Sugden MC, Caton PW, Holness MJ (2010) PPAR control: it's SIRTainly as easy as PGC. Journal of Endocrinology 204: 93-104.
53. Cho K, Kim SJ, Park SH, Kim S, Park T (2009) Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat. J Med Food 12: 1293-1301.
54. Shearn CT, Smathers RL, Jiang H, Orlicky DJ, Maclean KN, et al. (2013) Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis. J Nutr Biochem 24: 1436-1445.
55. Bader AG, Kang S, Zhao L, Vogt PK (2005) Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 5: 921-929. (Pubitemid 41766781)