Garlic oil alleviated ethanol-induced fat accumulation via modulation of SREBP-1, PPAR-α, and CYP2E1

Food and Chemical Toxicology

Volumn 50, Issue 3-4, 2012, Pages 485-491

  Zeng, Tao ^a   Zhang, Cui Li ^a   Song, Fu Yong ^a   Zhao, Xiu Lan ^a   Xie, Ke Qin ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

CYP2E1; Ethanol; Fatty liver; Garlic oil; PPAR ; SREBP 1c

Indexed keywords

CYTOCHROME P450 2E1; FATTY ACID SYNTHASE; GARLIC OIL; GLUTATHIONE; MALONALDEHYDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LEVEL; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFECT; FATTY LIVER; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIPID STORAGE; LIVER DYSFUNCTION; LIVER INJURY; LIVER MITOCHONDRION; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PROTEIN CONTENT; PROTEIN FUNCTION; SINGLE DRUG DOSE;

ADIPOSE TISSUE; ALLYL COMPOUNDS; ANIMALS; CELLS, CULTURED; CYTOCHROME P-450 CYP2E1; ETHANOL; MALE; MICE; PPAR ALPHA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; SULFIDES;

ALLIUM SATIVUM; MUS;

EID: 84862811285     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.11.030     Document Type: Article

References (41)

1. Agarwal M.K., Iqbal M., Athar M. Garlic oil ameliorates ferric nitrilotriacetate (Fe-NTA)-induced damage and tumor promotion: implications for cancer prevention. Food Chem. Toxicol. 2007, 45:1634-1640.
2. Albano E. Alcohol, oxidative stress and free radical damage. Proc. Nutr. Soc. 2006, 65:278-290.
3. Albano E. Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol. Aspects Med. 2008, 29:9-16.
4. Amagase H. Clarifying the real bioactive constituents of garlic. J. Nutr. 2006, 136:716S-725S.
5. Banerjee S.K., Mukherjee P.K., Maulik S.K. Garlic as an antioxidant: the good, the bad and the ugly. Phytother. Res. 2003, 17:97-106.
6. Bobboi A., Augusti K.T., Joseph P.K. Hypolipidemic effects of onion oil and garlic oil in ethanol-fed rats. Indian J. Biochem. Biophys. 1984, 21:211-213.
7. Butt M.S., Sultan M.T., Iqbal J. Garlic: nature's protection against physiological threats. Crit. Rev. Food Sci. Nutr. 2009, 49:538-551.
8. Cederbaum A.I., Lu Y., Wu D. Role of oxidative stress in alcohol-induced liver injury. Arch. Toxicol. 2009, 83:519-548.
9. Choi J.S., Yoon T.J., Kang K.R., Lee K.H., Kim W.H., Suh Y.H., Song J., Jung M.H. Glycoprotein isolated from Acanthopanax senticosus protects against hepatotoxicity induced by acute and chronic alcohol treatment. Biol. Pharm. Bull. 2006, 29:306-314.
10. Crabb D.W., Galli A., Fischer M., You M. Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha. Alcohol 2004, 34:35-38.
11. Day C.P., James O.F. Hepatic steatosis: innocent bystander or guilty party?. Hepatology 1998, 27:1463-1466.
12. Dey A., Cederbaum A.I. Alcohol and oxidative liver injury. Hepatology 2006, 43:S63-74.
13. Diluzio N.R. Prevention of the Acute Ethanol-Induced Fatty Liver by the Simultaneous Administration of Antioxidants. Life Sci. 1964, 3:113-118.
14. Emaus R.K., Grunwald R., Lemasters J.J. Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties. Biochim. Biophys. Acta 1986, 850:436-448.
15. Enomoto N., Ikejima K., Yamashina S., Enomoto A., Nishiura T., Nishimura T., Brenner D.A., Schemmer P., Bradford B.U., Rivera C.A., Zhong Z., Thurman R.G. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. Am. J. Physiol. Gastrointest Liver Physiol. 2000, 279:G100-106.
16. Espenshade P.J. SREBPs: sterol-regulated transcription factors. J. Cell Sci. 2006, 119:973-976.
17. Hassan H.A., El-Agmy S.M., Gaur R.L., Fernando A., Raj M.H., Ouhtit A. In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress. Int. J. Biol. Sci. 2009, 5:249-255.
18. Ji C., Chan C., Kaplowitz N. Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model. J. Hepatol. 2006, 45:717-724.
19. Konishi M., Iwasa M., Araki J., Kobayashi Y., Katsuki A., Sumida Y., Nakagawa N., Kojima Y., Watanabe S., Adachi Y., Kaito M. Increased lipid peroxidation in patients with non-alcoholic fatty liver disease and chronic hepatitis C as measured by the plasma level of 8-isoprostane. J. Gastroenterol. Hepatol. 2006, 21:1821-1825.
20. Kono H., Arteel G.E., Rusyn I., Sies H., Thurman R.G. Ebselen prevents early alcohol-induced liver injury in rats. Free Radic. Biol. Med. 2001, 30:403-411.
21. Liu H.G., Xu L.H. Garlic oil prevents tributyltin-induced oxidative damage in vivo and in vitro. J. Food Prot. 2007, 70:716-721.
22. Lu Y., Wu D., Wang X., Ward S.C., Cederbaum A.I. Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice. Free Radic. Biol. Med. 2010, 49:1406-1416.
23. Lu Y., Zhuge J., Wang X., Bai J., Cederbaum A.I. Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology 2008, 47:1483-1494.
24. McKim S.E., Konno A., Gabele E., Uesugi T., Froh M., Sies H., Thurman R.G., Arteel G.E. Cocoa extract protects against early alcohol-induced liver injury in the rat. Arch. Biochem. Biophys. 2002, 406:40-46.
25. Pai J.T., Guryev O., Brown M.S., Goldstein J.L. Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins. J. Biol. Chem. 1998, 273:26138-26148.
26. Palmieri V.O., Grattagliano I., Portincasa P., Palasciano G. Systemic oxidative alterations are associated with visceral adiposity and liver steatosis in patients with metabolic syndrome. J. Nutr. 2006, 136:3022-3026.
27. Ramaiah S., Rivera C., Arteel G. Early-phase alcoholic liver disease: an update on animal models, pathology, and pathogenesis. Int. J. Toxicol. 2004, 23:217-231.
28. Reinhart K.M., Talati R., White C.M., Coleman C.I. The impact of garlic on lipid parameters: a systematic review and meta-analysis. Nutr. Res. Rev. 2009, 22:39-48.
29. Ringseis R., Muschick A., Eder K. Dietary oxidized fat prevents ethanol-induced triacylglycerol accumulation and increases expression of PPARalpha target genes in rat liver. J. Nutr. 2007, 137:77-83.
30. Shimano H., Horton J.D., Shimomura I., Hammer R.E., Brown M.S., Goldstein J.L. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J. Clin. Invest. 1997, 99:846-854.
31. Shoetan A., Augusti K.T., Joseph P.K. Hypolipidemic effects of garlic oil in rats fed ethanol and a high lipid diet. Experientia 1984, 40:261-263.
32. Song Z., Zhou Z., Chen T., Hill D., Kang J., Barve S., McClain C. S-adenosylmethionine (SAMe) protects against acute alcohol induced hepatotoxicity in mice small star, filled. J. Nutr. Biochem. 2003, 14:591-597.
33. Wada S., Yamazaki T., Kawano Y., Miura S., Ezaki O. Fish oil fed prior to ethanol administration prevents acute ethanol-induced fatty liver in mice. J. Hepatol. 2008, 49:441-450.
34. Wu D., Wang X., Zhou R., Cederbaum A. CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophagy in HepG2 E47 cells. Biochem. Biophys. Res. Commun. 2010, 402:116-122.
35. Yin H.Q., Choi Y.J., Kim Y.C., Sohn D.H., Ryu S.Y., Lee B.H. Salvia miltiorrhiza Bunge and its active component cryptotanshinone protects primary cultured rat hepatocytes from acute ethanol-induced cytotoxicity and fatty infiltration. Food Chem. Toxicol. 2009, 47:98-103.
36. Yin H.Q., Kim M., Kim J.H., Kong G., Kang K.S., Kim H.L., Yoon B.I., Lee M.O., Lee B.H. Differential gene expression and lipid metabolism in fatty liver induced by acute ethanol treatment in mice. Toxicol. Appl. Pharmacol. 2007, 223:225-233.
37. Yin H.Q., Kim Y.C., Chung Y.S., Shin Y.K., Lee B.H. Honokiol reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element binding protein-1c and the expression of its downstream lipogenesis genes. Toxicol. Appl. Pharmacol. 2009, 236:124-130.
38. You M., Fischer M., Deeg M.A., Crabb D.W. Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). J. Biol. Chem. 2002, 277:29342-29347.
39. Zeng T., Guo F.F., Zhang C.L., Zhao S., Dou D.D., Gao X.C., Xie K.Q. The anti-fatty liver effects of garlic oil on acute ethanol-exposed mice. Chem. Biol. Interact. 2008, 176:234-242.
40. Zeng T., Xie K.Q. Ethanol and liver: recent advances in the mechanisms of ethanol-induced hepatosteatosis. Arch. Toxicol. 2009, 83:1075-1081.
41. Zeng T., Zhang C.L., Song F.Y., Han X.Y., Xie K.Q. The modulatory effects of garlic oil on hepatic cytochrome P450s in mice. Hum. Exp. Toxicol. 2009, 28:777-783.