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Volumn 7, Issue 7, 2012, Pages

Metabolic profiling in maturity-onset diabetes of the young (MODY) and young onset type 2 diabetes fails to detect robust urinary biomarkers

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; BETAINE; BIOLOGICAL MARKER; CHOLINE; GLUCOKINASE; GLUCOSE; GLYCINE; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; SARCOSINE; VALINE;

EID: 84864487679     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040962     Document Type: Article
Times cited : (15)

References (29)
  • 1
    • 79954628753 scopus 로고    scopus 로고
    • Prevalence of monogenic diabetes in young adults: a community-based, cross-sectional study in Oxfordshire, UK
    • Kropff J, Selwood MP, McCarthy MI, Farmer AJ, Owen KR, ((2011)) Prevalence of monogenic diabetes in young adults: a community-based, cross-sectional study in Oxfordshire, UK. Diabetologia 54:: 1261--1263.
    • (2011) Diabetologia , vol.54 , pp. 1261-1263
    • Kropff, J.1    Selwood, M.P.2    McCarthy, M.I.3    Farmer, A.J.4    Owen, K.R.5
  • 2
  • 3
    • 41149084500 scopus 로고    scopus 로고
    • Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes
    • Murphy R, Ellard S, Hattersley AT, ((2008)) Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes. Nat Clin Pract Endocrinol Metab 4:: 200--213.
    • (2008) Nat Clin Pract Endocrinol Metab , vol.4 , pp. 200-213
    • Murphy, R.1    Ellard, S.2    Hattersley, A.T.3
  • 4
    • 0142186278 scopus 로고    scopus 로고
    • Genetic cause of hyperglycaemia and response to treatment in diabetes
    • Pearson ER, Starkey BJ, Powell RJ, Gribble FM, Clark PM, et al. ((2003)) Genetic cause of hyperglycaemia and response to treatment in diabetes. Lancet 362:: 1275--1281.
    • (2003) Lancet , vol.362 , pp. 1275-1281
    • Pearson, E.R.1    Starkey, B.J.2    Powell, R.J.3    Gribble, F.M.4    Clark, P.M.5
  • 5
    • 41149139275 scopus 로고    scopus 로고
    • Best practice guidelines for the molecular genetic diagnosis of maturity-onset diabetes of the young
    • Ellard S, Bellanne-Chantelot C, Hattersley AT, ((2008)) Best practice guidelines for the molecular genetic diagnosis of maturity-onset diabetes of the young. Diabetologia 51:: 546--553.
    • (2008) Diabetologia , vol.51 , pp. 546-553
    • Ellard, S.1    Bellanne-Chantelot, C.2    Hattersley, A.T.3
  • 6
    • 80054692207 scopus 로고    scopus 로고
    • A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes
    • Thanabalasingham G, Shah N, Vaxillaire M, Hansen T, Tuomi T, et al. ((2011)) A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes. Diabetologia 54:: 2801--2810.
    • (2011) Diabetologia , vol.54 , pp. 2801-2810
    • Thanabalasingham, G.1    Shah, N.2    Vaxillaire, M.3    Hansen, T.4    Tuomi, T.5
  • 7
    • 66349097174 scopus 로고    scopus 로고
    • Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver
    • Servitja JM, Pignatelli M, Maestro MA, Cardalda C, Boj SF, et al. ((2009)) Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver. Mol Cell Biol 29:: 2945--2959.
    • (2009) Mol Cell Biol , vol.29 , pp. 2945-2959
    • Servitja, J.M.1    Pignatelli, M.2    Maestro, M.A.3    Cardalda, C.4    Boj, S.F.5
  • 8
    • 0035458854 scopus 로고    scopus 로고
    • The generalized aminoaciduria seen in patients with hepatocyte nuclear factor-1alpha mutations is a feature of all patients with diabetes and is associated with glucosuria
    • Bingham C, Ellard S, Nicholls AJ, Pennock CA, Allen J, et al. ((2001)) The generalized aminoaciduria seen in patients with hepatocyte nuclear factor-1alpha mutations is a feature of all patients with diabetes and is associated with glucosuria. Diabetes 50:: 2047--2052.
    • (2001) Diabetes , vol.50 , pp. 2047-2052
    • Bingham, C.1    Ellard, S.2    Nicholls, A.J.3    Pennock, C.A.4    Allen, J.5
  • 9
    • 75749155017 scopus 로고    scopus 로고
    • An investigation of serum concentration of apoM as a potential MODY3 marker using a novel ELISA
    • Cervin C, Axler O, Holmkvist J, Almgren P, Rantala E, et al. ((2010)) An investigation of serum concentration of apoM as a potential MODY3 marker using a novel ELISA. J Intern Med 267:: 316--321.
    • (2010) J Intern Med , vol.267 , pp. 316-321
    • Cervin, C.1    Axler, O.2    Holmkvist, J.3    Almgren, P.4    Rantala, E.5
  • 10
    • 49649102433 scopus 로고    scopus 로고
    • Can complement factors 5 and 8 and transthyretin be used as biomarkers for MODY 1 (HNF4A-MODY) and MODY 3 (HNF1A-MODY)
    • Karlsson E, Shaat N, Groop L, ((2008)) Can complement factors 5 and 8 and transthyretin be used as biomarkers for MODY 1 (HNF4A-MODY) and MODY 3 (HNF1A-MODY)? Diabet Med 25:: 788--791.
    • (2008) Diabet Med , vol.25 , pp. 788-791
    • Karlsson, E.1    Shaat, N.2    Groop, L.3
  • 11
    • 78649810544 scopus 로고    scopus 로고
    • Assessment of high-sensitivity C-reactive protein levels as diagnostic discriminator of maturity-onset diabetes of the young due to HNF1A mutations
    • Owen KR, Thanabalasingham G, James TJ, Karpe F, Farmer AJ, et al. ((2010)) Assessment of high-sensitivity C-reactive protein levels as diagnostic discriminator of maturity-onset diabetes of the young due to HNF1A mutations. Diabetes Care 33:: 1919--1924.
    • (2010) Diabetes Care , vol.33 , pp. 1919-1924
    • Owen, K.R.1    Thanabalasingham, G.2    James, T.J.3    Karpe, F.4    Farmer, A.J.5
  • 12
    • 75149183712 scopus 로고    scopus 로고
    • Evaluation of serum 1,5 anhydroglucitol levels as a clinical test to differentiate subtypes of diabetes
    • Pal A, Farmer AJ, Dudley C, Selwood MP, Barrow BA, et al. ((2010)) Evaluation of serum 1,5 anhydroglucitol levels as a clinical test to differentiate subtypes of diabetes. Diabetes Care 33:: 252--257.
    • (2010) Diabetes Care , vol.33 , pp. 252-257
    • Pal, A.1    Farmer, A.J.2    Dudley, C.3    Selwood, M.P.4    Barrow, B.A.5
  • 13
    • 0344412888 scopus 로고    scopus 로고
    • Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels
    • Richter S, Shih DQ, Pearson ER, Wolfrum C, Fajans SS, et al. ((2003)) Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels. Diabetes 52:: 2989--2995.
    • (2003) Diabetes , vol.52 , pp. 2989-2995
    • Richter, S.1    Shih, D.Q.2    Pearson, E.R.3    Wolfrum, C.4    Fajans, S.S.5
  • 14
    • 49649099316 scopus 로고    scopus 로고
    • Clinical application of 1,5-anhydroglucitol measurements in patients with hepatocyte nuclear factor-1alpha maturity-onset diabetes of the young
    • Skupien J, Gorczynska-Kosiorz S, Klupa T, Wanic K, Button EA, et al. ((2008)) Clinical application of 1,5-anhydroglucitol measurements in patients with hepatocyte nuclear factor-1alpha maturity-onset diabetes of the young. Diabetes Care 31:: 1496--1501.
    • (2008) Diabetes Care , vol.31 , pp. 1496-1501
    • Skupien, J.1    Gorczynska-Kosiorz, S.2    Klupa, T.3    Wanic, K.4    Button, E.A.5
  • 15
    • 55849089906 scopus 로고    scopus 로고
    • Evaluation of Apolipoprotein M Serum Concentration as a Biomarker of HNF-1alpha MODY
    • Skupien J, Kepka G, Gorczynska-Kosiorz S, Gebska A, Klupa T, et al. ((2007)) Evaluation of Apolipoprotein M Serum Concentration as a Biomarker of HNF-1alpha MODY. Rev Diabet Stud 4:: 231--235.
    • (2007) Rev Diabet Stud , vol.4 , pp. 231-235
    • Skupien, J.1    Kepka, G.2    Gorczynska-Kosiorz, S.3    Gebska, A.4    Klupa, T.5
  • 16
    • 3843061389 scopus 로고    scopus 로고
    • Serum amino acids in patients with mutations in the hepatocyte nuclear factor-1 alpha gene
    • Stride A, Pearson ER, Brown A, Gooding K, Castleden HA, et al. ((2004)) Serum amino acids in patients with mutations in the hepatocyte nuclear factor-1 alpha gene. Diabet Med 21:: 928--930.
    • (2004) Diabet Med , vol.21 , pp. 928-930
    • Stride, A.1    Pearson, E.R.2    Brown, A.3    Gooding, K.4    Castleden, H.A.5
  • 17
    • 80054845457 scopus 로고    scopus 로고
    • High-Sensitivity CRP Discriminates HNF1A-MODY From Other Subtypes of Diabetes
    • McDonald TJ, Shields BM, Lawry J, Owen KR, Gloyn AL, et al. ((2011)) High-Sensitivity CRP Discriminates HNF1A-MODY From Other Subtypes of Diabetes. Diabetes Care. 34:: 1860--1862.
    • (2011) Diabetes Care , vol.34 , pp. 1860-1862
    • McDonald, T.J.1    Shields, B.M.2    Lawry, J.3    Owen, K.R.4    Gloyn, A.L.5
  • 18
    • 78649411431 scopus 로고    scopus 로고
    • Metabolomics identifies novel Hnf1alpha-dependent physiological pathways in vivo
    • Bonzo JA, Patterson AD, Krausz KW, Gonzalez FJ, ((2010)) Metabolomics identifies novel Hnf1alpha-dependent physiological pathways in vivo. Mol Endocrinol 24:: 2343--2355.
    • (2010) Mol Endocrinol , vol.24 , pp. 2343-2355
    • Bonzo, J.A.1    Patterson, A.D.2    Krausz, K.W.3    Gonzalez, F.J.4
  • 19
    • 79953737332 scopus 로고    scopus 로고
    • Metabolite profiles and the risk of developing diabetes
    • Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, et al. ((2011)) Metabolite profiles and the risk of developing diabetes. Nat Med 17:: 448--453.
    • (2011) Nat Med , vol.17 , pp. 448-453
    • Wang, T.J.1    Larson, M.G.2    Vasan, R.S.3    Cheng, S.4    Rhee, E.P.5
  • 20
    • 79957581759 scopus 로고    scopus 로고
    • Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus
    • Patterson AD, Bonzo JA, Li F, Krausz KW, Eichler GS, et al. ((2011)) Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus. J Biol Chem 286:: 19511--19522.
    • (2011) J Biol Chem , vol.286 , pp. 19511-19522
    • Patterson, A.D.1    Bonzo, J.A.2    Li, F.3    Krausz, K.W.4    Eichler, G.S.5
  • 21
    • 21544451980 scopus 로고    scopus 로고
    • Beta-cell dysfunction, insulin sensitivity, and glycosuria precede diabetes in hepatocyte nuclear factor-1alpha mutation carriers
    • Stride A, Ellard S, Clark P, Shakespeare L, Salzmann M, et al. ((2005)) Beta-cell dysfunction, insulin sensitivity, and glycosuria precede diabetes in hepatocyte nuclear factor-1alpha mutation carriers. Diabetes Care 28:: 1751--1756.
    • (2005) Diabetes Care , vol.28 , pp. 1751-1756
    • Stride, A.1    Ellard, S.2    Clark, P.3    Shakespeare, L.4    Salzmann, M.5
  • 22
    • 0034304925 scopus 로고    scopus 로고
    • HNF1alpha controls renal glucose reabsorption in mouse and man
    • Pontoglio M, Prie D, Cheret C, Doyen A, Leroy C, et al. ((2000)) HNF1alpha controls renal glucose reabsorption in mouse and man. EMBO Rep 1:: 359--365.
    • (2000) EMBO Rep , vol.1 , pp. 359-365
    • Pontoglio, M.1    Prie, D.2    Cheret, C.3    Doyen, A.4    Leroy, C.5
  • 23
    • 79955864329 scopus 로고    scopus 로고
    • Choline and betaine in health and disease
    • Ueland PM, ((2011)) Choline and betaine in health and disease. J Inherit Metab Dis 34:: 3--15.
    • (2011) J Inherit Metab Dis , vol.34 , pp. 3-15
    • Ueland, P.M.1
  • 24
    • 0032917905 scopus 로고    scopus 로고
    • Elevated glycine betaine excretion in diabetes mellitus patients is associated with proximal tubular dysfunction and hyperglycemia
    • Dellow WJ, Chambers ST, Lever M, Lunt H, Robson RA, ((1999)) Elevated glycine betaine excretion in diabetes mellitus patients is associated with proximal tubular dysfunction and hyperglycemia. Diabetes Res Clin Pract 43:: 91--99.
    • (1999) Diabetes Res Clin Pract , vol.43 , pp. 91-99
    • Dellow, W.J.1    Chambers, S.T.2    Lever, M.3    Lunt, H.4    Robson, R.A.5
  • 25
    • 9644301171 scopus 로고    scopus 로고
    • Homocysteine, glycine betaine, and N, N-dimethylglycine in patients attending a lipid clinic
    • Lever M, George PM, Dellow WJ, Scott RS, Chambers ST, ((2005)) Homocysteine, glycine betaine, and N, N-dimethylglycine in patients attending a lipid clinic. Metabolism 54:: 1--14.
    • (2005) Metabolism , vol.54 , pp. 1-14
    • Lever, M.1    George, P.M.2    Dellow, W.J.3    Scott, R.S.4    Chambers, S.T.5
  • 26
    • 84859766869 scopus 로고    scopus 로고
    • Variability of plasma and urine betaine in diabetes mellitus and its relationship to methionine load test responses: an observational study
    • Lever M, Slow S, McGregor DO, Dellow WJ, George PM, et al. ((2012)) Variability of plasma and urine betaine in diabetes mellitus and its relationship to methionine load test responses: an observational study. Cardiovasc Diabetol 11:: 34.
    • (2012) Cardiovasc Diabetol , vol.11 , pp. 34
    • Lever, M.1    Slow, S.2    McGregor, D.O.3    Dellow, W.J.4    George, P.M.5
  • 27
    • 32444446805 scopus 로고    scopus 로고
    • XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification
    • Smith CA, Want EJ, O'Maille G, Abagyan R, Siuzdak G, ((2006)) XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal Chem 78:: 779--787.
    • (2006) Anal Chem , vol.78 , pp. 779-787
    • Smith, C.A.1    Want, E.J.2    O'Maille, G.3    Abagyan, R.4    Siuzdak, G.5
  • 28
    • 33745728718 scopus 로고    scopus 로고
    • Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures. Application in 1H NMR metabonomics
    • Dieterle F, Ross A, Schlotterbeck G, Senn H, ((2006)) Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures. Application in 1H NMR metabonomics. Anal Chem 78:: 4281--4290.
    • (2006) Anal Chem , vol.78 , pp. 4281-4290
    • Dieterle, F.1    Ross, A.2    Schlotterbeck, G.3    Senn, H.4
  • 29
    • 41149120242 scopus 로고    scopus 로고
    • Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models
    • Wiklund S, Johansson E, Sjostrom L, Mellerowicz EJ, Edlund U, et al. ((2008)) Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models. Anal Chem 80:: 115--122.
    • (2008) Anal Chem , vol.80 , pp. 115-122
    • Wiklund, S.1    Johansson, E.2    Sjostrom, L.3    Mellerowicz, E.J.4    Edlund, U.5


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