Synthesis, biological evaluation, and molecular docking studies of pyrazolyl-acylhydrazone derivatives as novel anticancer agents

Medicinal Chemistry Research

Volumn 23, Issue 7, 2014, Pages 3274-3286

  Xing, Man ^a   Zhao, Ting Ting ^a   Ren, Yu Jia ^a   Peng, Na Na ^a   Yang, Xian Hui ^a   Li, Xi ^a   Zhang, Hui ^a   Liu, Gao Qi ^b   Zhang, Li Rong ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

^b ZHENGZHOU UNIVERSITY   (China)

Author keywords

3D QSAR; Anticancer; Molecular docking; Pyrazolyl acylhydrazone derivatives; Telomerase

Indexed keywords

2 HYDROXY 3 METHYL N' [[1 PHENYL 3 (4 TOLYL) 1H PYRAZOL 4 YL]METHYLENE]BENZOHYDRAZIDE; 2 HYDROXY N' [[3 (4 METHOXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 3 METHYLBENZOHYDRAZIDE; 2 HYDROXY N' [[3 (4 METHOXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE]BENZOHYDRAZIDE; 5 BROMO 2 HYDROXY N' [[(3 (4 METHOXYPHENYL) 1 DIPHENYL 1H PYRAZOL 4 YL]METHYLENE]BENZOHYDRAZIDE; 5 BROMO 2 HYDROXY N' [[1 PHENYL 3 (4 TOLYL) 1H PYRAZOL 4 YL]METHYLENE]BENZOHYDRAZIDE; 5 BROMO N' [(1,3 DIPHENYL 4 YL)METHYLENE] 2 HYDROXYBENZOHYDRAZIDE; 5 BROMO N' [(3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL)METHYLENE] 2 HYDROXYBENZOHYDRAZIDE; 5 BROMO N' [(3 (4 FLUOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL)METHYLENE] 2 HYDROXYBENZOHYDRAZIDE; 5 CHLORO 2 HYDROXY N' [[(3 (4 METHOXYPHENYL) 1 DIPHENYL 1H PYRAZOL 4 YL]METHYLENE]BENZOHYDRAZIDE; 5 CHLORO 2 HYDROXY N' [[1 PHENYL 3 (4 TOLYL) 1H PYRAZOL 4 YL]METHYLENE]BENZOHYDRAZIDE; 5 CHLORO N' [(1,3 DIPHENYL 4 YL)METHYLENE] 2 HYDROXYBENZOHYDRAZIDE; 5 CHLORO N' [(3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL)METHYLENE] 2 HYDROXYBENZOHYDRAZIDE; 5 CHLORO N' [(3 (4 FLUOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL)METHYLENE] 2 HYDROXYBENZOHYDRAZIDE; ANTINEOPLASTIC AGENT; FLUOROURACIL; N' [(1,3 DIPHENYL 1H PYRAZOL 4 YL)METHYLENE] 2 HYDROXY 3 METHYLBENZOHYDRAZIDE; N' [(1,3 DIPHENYL 1H PYRAZOL 4 YL)METHYLENE] 2 HYDROXYBENZOHYDRAZIDE; N' [(3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL)METHYLENE] 2 HYDROXY 3 METHYLBENZOHYDRAZIDE; N' [(3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL)METHYLENE] 2 HYDROXYBENZOHYDRAZIDE; N' [(3 (4 FLUOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL)METHYLENE] 2 HYDROXY 3 METHYLBENZOHYDRAZIDE; N' [(3 (4 FLUOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL)METHYLENE] 2 HYDROXYBENZOHYDRAZIDE; N' [[1 PHENYL 3 (4 TOLYL) 1H PYRAZOL 4 YL]METHYLENE]BENZOHYDRAZIDE; PYRAZOLYL ACYLHYDRAZONE DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL LINE; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

EID: 84902381248     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-014-0909-0     Document Type: Article

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