Synthesis, biological evaluation, and molecular docking studies of 2,6-dinitro-4-(trifluoromethyl)phenoxysalicylaldoxime derivatives as novel antitubulin agents

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 10, 2012, Pages 3233-3241

  Zhao, Ting Ting ^a   Lu, Xiang ^a   Yang, Xian Hui ^a   Wang, Li Ming ^a   Li, Xi ^a   Wang, Zhong Chang ^a   Gong, Hai Bin ^b   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

^b XUZHOU CENTRAL HOSPITAL   (China)

Author keywords

2* 6 Dinitro 4 (trifluoromethyl)phenoxysalicylaldoxime derivatives; Antitubulin polymerization; Molecular docking; Structure activity relationship

Indexed keywords

2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE O (2 CHLOROBENZYL)OXIME; 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE O (2 FLUOROBENZYL)OXIME; 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE O (2,4 DICHLOROBENZYL)OXIME; 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE O BENZYLOXIME; 2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXYSALICYLALDOXIME DERIVATIVE; 3,5 DIBROMO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE O (2 CHLOROBENZYL)OXIME; 3,5 DIBROMO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE O (2 FLUOROBENZYL)OXIME; 3,5 DIBROMO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE O (2,4 DICHLOROBENZYL)OXIME; 3,5 DIBROMO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE O BENZYLOXIME; 3,5 DICHLORO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE O (2 CHLOROBENZYL)OXIME; 3,5 DICHLORO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE O (2 FLUOROBENZYL)OXIME; 3,5 DICHLORO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE O (2,4 DICHLOROBENZYL)OXIME; 3,5 DICHLORO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE O BENZYLOXIME; 5 BROMO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE O (2 CHLOROBENZYL)OXIME; 5 BROMO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE O (2 FLUOROBENZYL)OXIME; 5 BROMO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE O (2,4 DICHLOROBENZYL)OXIME; 5 BROMO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE O BENZYLOXIME; 5 CHLORO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE O (2 CHLOROBENZYL)OXIME; 5 CHLORO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE O (2 FLUOROBENZYL)OXIME; 5 CHLORO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE O (2,4 DICHLOROBENZYL)OXIME; 5 CHLORO 2 [2,6 DINITRO 4 (TRIFLUOROMETHYL)PHENOXY]BENZALDEHYDE O BENZYLOXIME; COLCHICINE; SALICYLALDOXIME; TUBULIN; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BINDING SITE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; PROTEIN POLYMERIZATION;

APOPTOSIS; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTER SIMULATION; DRUG SCREENING ASSAYS, ANTITUMOR; FLOW CYTOMETRY; FLUORINE; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXIMES; POLYMERIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN MODULATORS;

EID: 84860486758     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.03.057     Document Type: Article

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