Synthesis, biological evaluation, and molecular docking studies of 1,3,4-oxadiazole derivatives possessing 1,4-benzodioxan moiety as potential anticancer agents

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 21, 2011, Pages 6518-6524

  Zhang, Xiao Min ^a   Qiu, Min ^a   Sun, Juan ^a   Zhang, Yan Bin ^a   Yang, Yu Shun ^a   Wang, Xiao Liang ^a   Tang, Jian Feng ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

1,3,4 Oxadiazole derivatives; Antitumor activity; Molecular docking; Synthesis; Telomerase inhibitor

Indexed keywords

1,3,4 OXADIAZOLE DERIVATIVE; 1,4 BENZODIOXAN; 2 (2 BROMOBENZYLTHIO) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 1,3,4 OXADIAZOLE; 2 (2 CHLOROBENZYLTHIO) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (2 FLUOROBENZYLTHIO) 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (2 IODOBENZYLTHIO) 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (2 METHYLBENZYLTHIO) 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (2 NITROBENZYLTHIO) 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (3 METHYLBENZYLTHIO) 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (3 NITROBENZYLTHIO) 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (4 FLUOROBENZYLTHIO) 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (4 IODOBENZYLTHIO) 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (4 METHYLBENZYLTHIO) 1,3,4 OXADIAZOLE; 2 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 5 (4 NITROBENZYLTHIO) 1,3,4 OXADIAZOLE; 2 (2,4 DIFLUOROBENZYLTHIO) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 1,3,4 OXADIAZOLE; 2 (2,6 DIFLUOROBENZYLTHIO) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 1,3,4 OXADIAZOLE; 2 (3 BROMOBENZYLTHIO) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 1,3,4 OXADIAZOLE; 2 (3 CHLOROBENZYLTHIO) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 1,3,4 OXADIAZOLE; 2 (4 BROMOBENZYLTHIO) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 1,3,4 OXADIAZOLE; 2 (4 CHLOROBENZYLTHIO) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 1,3,4 OXADIAZOLE; 2 (BENZYLTHIO) 5 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 1,3,4 OXADIAZOLE; ANTINEOPLASTIC AGENT; FLUOROURACIL; STAUROSPORINE; TELOMERASE; TELOMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; CANCER CELL CULTURE; CELL PROLIFERATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME STRUCTURE; ESTERIFICATION; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MODEL; PHARMACOLOGICAL PARAMETERS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY;

EID: 80054890022     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.08.013     Document Type: Article

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