Carbohydrate coingestion delays dietary protein digestion and absorption but does not modulate postprandial muscle protein accretion

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 6, 2014, Pages 2250-2258

  Gorissen, Stefan H M ^a,b   Burd, Nicholas A ^a,b   Hamer, Henrike M ^a,b   Gijsen, Annemie P ^b   Groen, Bart B ^b   Van Loon, Luc J C ^a,b  

^a TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

PHENYLALANINE;

ADULT; AGE; AGED; ARTICLE; BLOOD ANALYSIS; CARBOHYDRATE INTAKE; DIGESTION; GASTROINTESTINAL ABSORPTION; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; MUSCLE BIOPSY; NORMAL HUMAN; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROTEIN INTAKE; PROTEIN METABOLISM; PROTEIN SYNTHESIS;

AGED; AGING; BLOOD GLUCOSE; DIETARY CARBOHYDRATES; DIETARY PROTEINS; DIGESTION; EATING; HUMANS; INTESTINAL ABSORPTION; MALE; MUSCLE PROTEINS; PHENYLALANINE; POSTPRANDIAL PERIOD; YOUNG ADULT;

EID: 84902310642     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-3970     Document Type: Article

References (41)

1. Cuthbertson D, Smith K, Babraj J, et al. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J. 2005;19:422-424.
2. Durham WJ, Casperson SL, Dillon EL, et al. Age-related anabolic resistance after endurance-type exercise in healthy humans. FASEB J. 2010;24:4117-4127.
3. Fujita S, Glynn EL, Timmerman KL, Rasmussen BB, Volpi E. Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age related insulin resistance of muscle protein metabolism. Diabetologia. 2009;52:1889-1898.
4. Guillet C, Prod'homme M, Balage M, et al. Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans. FASEB J. 2004;18:1586-1587.
5. Kumar V, Selby A, Rankin D, et al. Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men. J Physiol. 2009;587:211-217.
6. Volpi E, Mittendorfer B, Rasmussen BB, Wolfe RR. The response of muscle protein anabolism to combined hyperaminoacide mia and glucose-induced hyperinsulinemia is impaired in the elderly. J Clin Endocrinol Metab. 2000;85:4481-4490.
7. Burd NA, Gorissen SH, van Loon LJ. Anabolic resistance of muscle protein synthesis with aging. Exerc Sport Sci Rev. 2013;41(3):169-173.
8. Boirie Y, Gachon P, Beaufrere B. Splanchnic and whole-body leucine kinetics in young and elderly men. Am J Clin Nutr. 1997;65: 489-495.
9. Gaudichon C, Mahe S, Benamouzig RD, et al. Net postprandial utilization of [15N]-labeled milk protein nitrogen is influenced by diet composition in humans. J Nutr. 1999;129:890-895.
10. Fouillet H, Gaudichon C, Mariotti F, Bos C, Huneau JF, Tome D. Energy nutrients modulate the splan chnic sequestration of dietary nitrogen in humans: a compartmental analysis. Am J Physiol Endocrinol Metab. 2001;281:E248-E260.
11. Koopman R, Walrand S, Beelen M, et al. Dietary protein digestio n and absorption rates and the subsequent postprandial muscle protein synthetic response do not differ between young and elderly men. J Nutr. 2009;139:1707-1713.
12. Pennings B,KoopmanR, BeelenM,Senden JM, SarisWH,van Loon LJ. Exercising before protein intake allows for greater use of dietary protein-derived amino acids for de novo muscle protein synthesis in both young and elderly men. Am J Clin Nutr. 2011;93:322-331.
13. Pennings B, Pellikaan WF, Senden JM, van Vuuren AM, Sikkema J, van Loon LJ. The production of intrinsically labeled milk and meat protein is feasible and provides functional tools for human nutrition research. J Dairy Sci. 2011;94:4366-4373.
14. van Loon LJ, Boirie Y, Gijsen AP, et al. The production of intrinsically labeled milk protein provides a functional tool for human nutrition research. J Dair y Sci. 2009;92:4812-4822.
15. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15:539-553.
16. Abumrad NN, Rabin D, Diamond MP, Lacy WW. Use of a heated superficial hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man. Metabolism. 1981;30:936-940.
17. Bergstrom J Percutaneous needle biopsy of skeletal muscle in physiological and clinical research Scand J Clin Lab Invest. 1975 35 609-616.
18. Boirie Y, Gachon P, Corny S, Fauquant J, Maubois JL, Beaufrere B. Acute postprandial changes in leucine metabolism as assessed with an intrins ically labeled milk protein. Am J Physiol. 1996;271: E1083-E1091.
19. Dangin M, Guillet C, Garcia-Rodenas C, et al. The rate of protein digestion affects protein gain differently during aging in humans. J Physiol. 2003;549:635-644.
20. Hamer HM, Wall BT, Kiskini A, et al. Carbohydrate co-ingestion with protein does not further augment post-prandial muscle protein accretion in older men. Nutr Metab (Lond). 2013;10:15.
21. Koopman R, Beelen M, Stellingwerff T, et al. Coingestion of carbohydrate with protein does not further augment postexercise muscle protein synthesis. Am J Physiol Endocrinol Metab. 2007;293: E833-E842.
22. Staples AW, Burd NA, West DW, et al. Carbohydrate does not augment exercise-induced protein accretion versus protein alone. Med Sci Sports Exerc. 2011;43:1154-1161.
23. Calbet JA, MacLean DA. Role of caloric content on gastric emptying in humans. J Physiol. 1997;498( Pt 2):553-559.
24. Phillips SM. Insulin and muscle protein turnover in humans: stimulatory, permissive, inhibitory, or all of the above? Am J Physiol Endocrinol Metab. 2008;295:E731.
25. Timmerman KL, L ee JL, Dreyer HC, et al. Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling. J Clin Endocrinol Metab. 2010;95: 3848-3857.
26. Timmerman KL, Lee JL, Fujita S, et al. Pharmacological vasodilation improves insulin-stimulated muscle protein anabolism but not glucose utilization in older adults. Diabete s. 2010;59:2764-2771.
27. Greenhaff PL, Karagounis LG, Peirce N, et al. Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human mu scle. Am J Physiol Endocrinol Metab. 2008;295:E595-E604.
28. Guillet C, Zangarelli A, Gachon P, et al. Whole body protein breakdown is less inhibited by insulin, but still responsive to amino aci d, in nondiabetic elderly subjects. J Clin Endocrinol Metab. 2004;89: 6017-6024.
29. Volpi E, Sheffield-Moore M, Rasmussen BB, Wolfe RR. Basal muscle amino acid kinetics and protein synthesis in healthy young and older men. JAMA. 2001;286:1206-1212.
30. Katsanos CS, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR. Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am J Clin Nutr. 2005;82:1065-1073.
31. Drummond MJ, Dreyer HC, Pennings B, et al. Skeletal muscle protein anabolic response to resis tance exercise and essential amino acids is delayed with aging. J Appl Physiol. 2008;104:1452-1461.
32. Glynn EL, Fry CS, Drummond MJ, et al. Muscle protein breakdown has a minor role in the prot ein anabolic response to essential amino acid and carbohydrate intake following resistance exercise. Am J Physiol Regul Integr Comp Physiol. 2010;299:R533-R540.
33. Glynn EL, Fry CS, Timmerman KL, Dr ummond MJ, Volpi E, Rasmussen BB. Addition of carbohydrate or alanine to an essential amino acid mixture does not enhance human skeletal muscle protein anabolism. J Nutr. 2013;143(3):307-314.
34. He nderson GC, Dhatariya K, Ford GC, et al. Higher muscle protein synthesis in women than men across the lifespan, and failure of androgen administration to amend age-related decrements. FASEB J. 2009;23:631-641.
35. Smith GI, Atherton P, Villareal DT, et al. Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women. PLoS One. 2008;3:e1875.
36. Smith GI, Reeds DN, Hall AM, Chambers KT, Finck BN, Mittendorfer B. Sexually dimorphic effect of aging on skeletal muscle protein synthesis. Biol Sex Differ. 2012;3:11.
37. Smith GI, Villareal DT, Sinacore DR, Shah K, Mittendorfer B. Muscle protein synthesis response to exercise training in obese, oldermen and women. Med Sci Sports Exerc. 2012;44(7):1259-1266.
38. Fujita S, Rasmussen BB, Bell JA, Cadenas JG, Volpi E. Basal muscle intracellular amino acid kinetics in women and men. Am J Physiol Endocrinol Metab. 2007;292:E77-E83.
39. Jahn LA,Barrett EJ,Genco ML,Wei L,Spraggins TA,Fryburg DA Tissue composition affects measures of postabsorptive human skeletal muscle metabolism: comparison across genders J Clin Endocrinol Metab. 1999 84 1007-1010.
40. Smith GI, Atherton P, Reeds DN, et al. No major sex differences in muscle protein synthesis rates in the postabsorptive state and during hyperinsulinemia-hyperaminoacidemia in mid dle-aged adults. J Appl Physiol (1985). 2009;107:1308-1315.
41. West DW, Burd NA, Churchward-Venne TA, et al. Sex-based comparisons of myofibrillar protein synthesis after resistance exercis e in the fed state. J Appl Physiol (1985). 2012;112:1805-1813.