Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: Evidence of a true age-related insulin resistance of muscle protein metabolism

Diabetologia

Volumn 52, Issue 9, 2009, Pages 1889-1898

  Fujita, S ^a,b   Glynn, E L ^a   Timmerman, K L ^a   Rasmussen, B B ^a   Volpi, E ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Ageing; Insulin; Insulin resistance; Muscle protein synthesis; Sarcopenia

Indexed keywords

AMINO ACID; GLUCOSE; INSULIN; ISOTOPE; MAMMALIAN TARGET OF RAPAMYCIN; MUSCLE PROTEIN; PHENYLALANINE; PROTEIN KINASE B; PROTEIN P70;

AGED; AGING; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DYE DILUTION CURVE; FEMALE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; HYPERINSULINEMIA; IMMUNOBLOTTING; INSULIN RESISTANCE; LEG BLOOD FLOW; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ANIMALS; BIOPSY; BLOOD GLUCOSE; BODY MASS INDEX; FEMALE; FEMORAL ARTERY; HUMANS; HYPERINSULINISM; INSULIN; INSULIN RESISTANCE; LEG; MALE; METABOLISM; MUSCLE PROTEINS; MUSCLE, SKELETAL; REFERENCE VALUES; REGIONAL BLOOD FLOW;

EID: 68449094247     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1430-8     Document Type: Article

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