Anabolic resistance of muscle protein synthesis with aging

Exercise and Sport Sciences Reviews

Volumn 41, Issue 3, 2013, Pages 169-173

  Burd, Nicholas A ^a   Gorissen, Stefan H ^a   Van Loon, Luc J C ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

amino acids; dietary protein; exercise; mTORC1; sarcopenia

Indexed keywords

AMINO ACID; MUSCLE PROTEIN;

AGING; ARTICLE; BIOSYNTHESIS; BLOOD; EATING; EXERCISE; HUMAN; PHYSIOLOGY; POSTPRANDIAL STATE;

AGING; AMINO ACIDS; EATING; EXERCISE; HUMANS; MUSCLE PROTEINS; POSTPRANDIAL PERIOD;

EID: 84880192503     PISSN: 00916331     EISSN: 15383008     Source Type: Journal    
DOI: 10.1097/JES.0b013e318292f3d5     Document Type: Article

References (35)

1. Boirie Y, Gachon P, Beaufrere B. Splanchnic and whole-body leucine kinetics in young and elderly men. Am. J. Clin. Nutr. 1997; 65:489-95.
2. Burd NA, Wall BT, van Loon LJ. The curious case of anabolic resistance: Old wives" tales or new fables? J. Appl. Physiol. 2012; 112:1233-5.
3. Burd NA, West DW, Moore DR, et al. Enhanced amino acid sensitivity of myofibrillar protein synthesis persists for up to 24 h after resistance exercise in young men. J. Nutr. 2011; 141:568-73.
4. Churchward-Venne TA, Burd NA, Mitchell CJ, et al. Supplementation of a suboptimal protein dose with leucine or essential amino acids: Effects on myofibrillar protein synthesis at rest and following resistance exercise in men. J. Physiol. 2012; 590(Pt 11):2751-65.
5. Cuthbertson D, Smith K, Babraj J, et al. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J. 2005; 19:422-4.
6. Dickinson JM, Drummond MJ, Coben JR, Volpi E, Rasmussen BB. Aging differentially affects human skeletal muscle amino acid transporter expression when essential amino acids are ingested after exercise. Clin Nutr. 2012;32:273-280.
7. Drummond MJ, Dickinson JM, Fry CS, et al. Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults. Am. J. Physiol. 2012; 302:E1113-22.
8. Fry CS, Drummond MJ, Glynn EL, et al. Aging impairs contractioninduced human skeletal muscle mTORC1 signaling and protein synthesis. Skelet. Muscle. 2011; 1:11.
9. Fujita S, Glynn EL, Timmerman KL, Rasmussen BB, Volpi E. Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: Evidence of a true age-related insulin resistance of muscle protein metabolism. Diabetologia. 2009; 52:1889-98.
10. Fujita S, Rasmussen BB, Cadenas JG, et al. Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling. Diabetes. 2007; 56:1615-22.
11. Glover EI, Phillips SM, Oates BR, et al. Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion. J. Physiol. 2008; 586(Pt 24):6049-61.
12. Goodpaster BH, Park SW, Harris TB, et al. The loss of skeletal muscle strength, mass, and quality in older adults: The health, aging and body composition study. J. Gerontol. A. Biol. Sci. Med. Sci. 2006; 61:1059-64.
13. Greenhaff PL, Karagounis LG, Peirce N, et al. Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle. Am. J. Physiol. 2008; 295:E595-604.
14. Groen BB, Res PT, Pennings B, et al. Intragastric protein administration stimulates overnight muscle protein synthesis in elderly men. Am. J. Physiol. 2012; 302:E52-60.
15. Guillet C, Prodhomme M, Balage M, et al. Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans. FASEB J. 2004; 18:1586-7.
16. Katsanos CS, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR. Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am. J. Clin. Nutr. 2005; 82:1065-73.
17. Katsanos CS, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am. J. Physiol. 2006; 291:E381-7.
18. Koopman R, Crombach N, Gijsen AP, et al. Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein. Am. J. Clin. Nutr. 2009; 90:106-15.
19. Koopman R, Verdijk L, Manders RJ, et al. Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men. Am. J. Clin. Nutr. 2006; 84:623-32.
20. Koopman R, Walrand S, Beelen M, et al. Dietary protein digestion and absorption rates and the subsequent postprandial muscle protein synthetic response do not differ between young and elderly men. J. Nutr. 2009; 139:1707-13.
21. Kumar V, Selby A, Rankin D, et al. Age-related differences in the doseresponse relationship of muscle protein synthesis to resistance exercise in young and old men. J. Physiol. 2009; 587(Pt 1):211-7.
22. Moore DR, Robinson MJ, Fry JL, et al. Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. Am. J. Clin. Nutr. 2009; 89:161-8.
23. Paddon-Jones D, Rasmussen BB. Dietary protein recommendations and the prevention of sarcopenia. Curr. Opin. Clin. Nutr. Metab. Care. 2009; 12:86-90.
24. Pennings B, Boirie Y, Senden JM, Gijsen AP, Kuipers H, van Loon LJ. Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men. Am. J. Clin. Nutr. 2011; 93:997-1005.
25. Pennings B, Groen B, de Lange A, et al. Amino acid absorption and subsequent muscle protein accretion following graded intakes of whey protein in elderly men. Am. J. Physiol. 2012; 302:E992-9.
26. Pennings B, Koopman R, Beelen M, Senden JM, Saris WH, van Loon LJ. Exercising before protein intake allows for greater use of dietary proteinderived amino acids for de novo muscle protein synthesis in both young and elderly men. Am. J. Clin. Nutr. 2011; 93:322-31.
27. Rasmussen BB, Fujita S, Wolfe RR, et al. Insulin resistance of muscle protein metabolism in aging. FASEB J. 2006; 20:768-9.
28. Rennie MJ, Selby A, Atherton P, et al. Facts, noise and wishful thinking: Muscle protein turnover in aging and human disuse atrophy. Scand. J. Med. Sci. Sports. 2010; 20:5-9.
29. Short KR, Vittone JL, Bigelow ML, Proctor DN, Nair KS. Age and aerobic exercise training effects on whole body and muscle protein metabolism. Am. J. Physiol. 2004; 286:E92-101.
30. Timmerman KL, Dhanani S, Glynn EL, et al. A moderate acute increase in physical activity enhances nutritive flow and the muscle protein anabolic response to mixed nutrient intake in older adults. Am. J. Clin. Nutr. 2012; 95:1403-12.
31. Timmerman KL, Lee JL, Fujita S, et al. Pharmacological vasodilation improves insulin-stimulated muscle protein anabolism but not glucose utilization in older adults. Diabetes. 2010; 59:2764-71.
32. Volpi E, Mittendorfer B, Rasmussen BB, Wolfe RR. The response of muscle protein anabolism to combined hyperaminoacidemia and glucoseinduced hyperinsulinemia is impaired in the elderly. J. Clin. Endocrinol. Metab. 2000; 85:4481-90.
33. Volpi E, Mittendorfer B, Wolf SE, Wolfe RR. Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction. Am. J. Physiol. 1999; 277(3 Pt 1):E513-20.
34. Volpi E, Sheffield-Moore M, Rasmussen BB, Wolfe RR. Basal muscle amino acid kinetics and protein synthesis in healthy young and older men. JAMA. 2001; 286:1206-12.
35. Yang Y, Breen L, Burd NA, et al. Resistance exercise enhances myofibrillar protein synthesis with graded intakes of whey protein in older men. Br. J. Nutr. 2012; 108:1780-8.