The novel calpain inhibitor A-705253 prevents stress-induced tau hyperphosphorylation in vitro and in vivo

Neuropharmacology

Volumn 63, Issue 4, 2012, Pages 606-612

  Nikkel, Arthur L ^a   Martino, Brenda ^a   Markosyan, Stella ^a   Brederson, Jill Desiree ^a   Medeiros, Rodrigo ^c   Moeller, Achim ^b   Bitner, Robert S ^a  

^a ABBOTT LABORATORIES   (United States)

^b ABBOTT GMBH AND CO KG   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; Calpain; Hippocampus; Stress; Tau hyperphosphorylation

Indexed keywords

A 705253; CYCLIN DEPENDENT KINASE 5; CYSTEINE PROTEINASE INHIBITOR; LIPOPOLYSACCHARIDE; N (1 BENZYL 2 CARBAMOYL 2 OXOETHYL) 2 [2 (4 DIETHYLAMINOMETHYLPHENYL) ETHEN 1 YLBENZAMIDE]; PENTOBARBITAL; PROTEIN P25; TAU PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DRUG EFFECT; HIPPOCAMPAL CA3 REGION; HIPPOCAMPAL MOSSY FIBER; HIPPOCAMPUS; HYPOTHERMIA; IN VITRO STUDY; IN VIVO STUDY; LOW TEMPERATURE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STRESS;

ALZHEIMER DISEASE; ANIMALS; BENZAMIDES; CALPAIN; COLD TEMPERATURE; CYSTEINE PROTEINASE INHIBITORS; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; MALE; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MOLECULAR TARGETED THERAPY; MOSSY FIBERS, HIPPOCAMPAL; NEURONS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; STRESS, PHYSIOLOGICAL; TAU PROTEINS;

EID: 84863607935     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.05.011     Document Type: Article

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