Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in mice

Journal of Biological Chemistry

Volumn 280, Issue 1, 2005, Pages 548-555

  Xu, Lin ^a   Peng, Haibing ^b   Wu, Dongying ^c   Hu, Kenpan ^c   Goldring, Mary B ^b   Olsen, Bjorn E ^a,c   Li, Yefu ^c,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD INSTITUTES OF MEDICINE   (United States)

^c HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARTILAGE; COLLAGEN; GENETIC ENGINEERING; HUMAN ENGINEERING; JOINTS (ANATOMY); MUTAGENESIS;

DISCOIDIN DOMAIN RECEPTOR 2 (DDR2); MATRIX METALLOPROTEINASE 13 (MMP-13); OSTEOARTHRITIS (OA); RECEPTORS;

ENZYMES;

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ADAMTS 4; ADAMTS 5; AGGRECANASE; CELL SURFACE RECEPTOR; COLLAGEN RECEPTOR; COLLAGEN TYPE 2; COLLAGEN TYPE 9; COLLAGENASE 3; DISCOIDIN; DISCOIDIN DOMAIN RECEPTOR 2; INTERLEUKIN 1; INTERSTITIAL COLLAGENASE; MESSENGER RNA; NEUTROPHIL COLLAGENASE; STROMELYSIN; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE MATRIX; CELL SURFACE; CONTROLLED STUDY; DISEASE MODEL; ENZYME ACTIVITY; ENZYME INDUCTION; GENE OVEREXPRESSION; GENETIC DISORDER; HETEROZYGOTE; IN VITRO STUDY; MOUSE; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION;

ANIMALS; CHONDROCYTES; COLLAGEN TYPE II; COLLAGEN TYPE XI; COLLAGENASES; ENZYME ACTIVATION; ENZYME INDUCTION; KNEE JOINT; LIGANDS; MATRIX METALLOPROTEINASE 13; MICE; OSTEOARTHRITIS, KNEE; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, MITOGEN;

ANIMALIA;

EID: 12844287561     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M411036200     Document Type: Article

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