Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1

Cell Metabolism

Volumn 19, Issue 6, 2014, Pages 967-980

  Liu, Meilian ^a,b   Bai, Juli ^a,b   He, Sijia ^a,b   Villarreal, Ricardo ^c   Hu, Derong ^a   Zhang, Chuntao ^a,d   Yang, Xin ^c   Liang, Huiyun ^c   Slaga, Thomas J ^a   Yu, Yonghao ^e   Zhou, Zhiguang ^b   Blenis, John ^e   Scherer, Philipp E ^f   Dong, Lily Q ^c   Liu, Feng ^a,b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c Mays Cancer Center at UT Health San Antonio   (United States)

^d XINJIANG MEDICAL UNIVERSITY   (China)

^e HARVARD MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR RECEPTOR BOUND PROTEIN 10; INSULIN RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET RAPAMYCIN COMPLEX 1; PHOSPHATIDYLINOSITOL 3 KINASE; RAPAMYCIN; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; ANTINEOPLASTIC ANTIBIOTIC; GRB10 PROTEIN, MOUSE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; PROTEIN BINDING; PROTEIN KINASE B; RPTOR PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; SERINE;

ADIPOCYTE; ANIMAL CELL; ARTICLE; BROWN ADIPOSE TISSUE; COLD EXPOSURE; COLD STRESS; CONTROLLED STUDY; ENERGY EXPENDITURE; FEMALE; IN VIVO STUDY; LIPOLYSIS; MALE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; NONSHIVERING THERMOGENESIS; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAPTOR; TISSUE SPECIFICITY; WHITE ADIPOSE TISSUE; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL CULTURE; COLD; COLD SHOCK RESPONSE; DIABETES MELLITUS; ENERGY METABOLISM; FEEDBACK SYSTEM; INSULIN RESISTANCE; KNOCKOUT MOUSE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; THERMOGENESIS; ADIPOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; DIET; FATTY LIVER; LIPID STORAGE; LIPOGENESIS; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELLS, CULTURED; COLD TEMPERATURE; COLD-SHOCK RESPONSE; DIABETES MELLITUS; ENERGY METABOLISM; FEEDBACK, PHYSIOLOGICAL; GRB10 ADAPTOR PROTEIN; INSULIN RESISTANCE; LIPOLYSIS; MICE; MICE, KNOCKOUT; MULTIPROTEIN COMPLEXES; OBESITY; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; SIROLIMUS; THERMOGENESIS; TOR SERINE-THREONINE KINASES;

EID: 84902257417     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2014.03.018     Document Type: Article

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