메뉴 건너뛰기




Volumn 2014, Issue , 2014, Pages

Insulin increases ceramide synthesis in skeletal muscle

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; DIACYLGLYCEROL ACYLTRANSFERASE 1; INSULIN; PALMITIC ACID; SERINE PALMITOYLTRANSFERASE SUBUNIT 1; SERINE PALMITOYLTRANSFERASE SUBUNIT 2; SPHINGOLIPID; SPHINGOLIPID DELTA(4) DESATURASE; TRANSFERASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; CHAPERONE; LIPID; PALMITIC ACID DERIVATIVE; SPT2 PROTEIN, MOUSE;

EID: 84902206970     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2014/765784     Document Type: Article
Times cited : (21)

References (63)
  • 1
    • 84869831903 scopus 로고    scopus 로고
    • Diabetes: Have we got it all wrong? Hyperinsulinism as the culprit: Surgery provides the evidence
    • 10.2337/dc12-0684
    • Pories W. J., Dohm G. L., Diabetes: have we got it all wrong? Hyperinsulinism as the culprit: surgery provides the evidence. Diabetes Care 2012 35 12 2438 2442 10.2337/dc12-0684
    • (2012) Diabetes Care , vol.35 , Issue.12 , pp. 2438-2442
    • Pories, W.J.1    Dohm, G.L.2
  • 2
    • 0024244339 scopus 로고
    • Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM
    • Reaven G. M., Hollenbeck C., Jeng C.-Y., Wu M. S., Chen Y.-D. I., Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM. Diabetes 1988 37 8 1020 1024 2-s2.0-0024244339 (Pubitemid 19033579)
    • (1988) Diabetes , vol.37 , Issue.8 , pp. 1020-1024
    • Reaven, G.M.1    Hollenbeck, C.2    Jeng, C.-Y.3    Wu, M.S.4    Chen, Y.-D.I.5
  • 4
    • 0026468362 scopus 로고
    • What if Minkowski had been ageusic? An alternative angle on diabetes
    • 2-s2.0-0026468362
    • McGarry J. D., What if Minkowski had been ageusic? An alternative angle on diabetes. Science 1992 258 5083 766 770 2-s2.0-0026468362
    • (1992) Science , vol.258 , Issue.5083 , pp. 766-770
    • McGarry, J.D.1
  • 5
    • 76049095119 scopus 로고    scopus 로고
    • Lipid oversupply, selective insulin resistance, and lipotoxicity: Molecular mechanisms
    • 2-s2.0-76049095119 10.1016/j.bbalip.2009.09.015
    • Chavez J. A., Summers S. A., Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms. Biochimica et Biophysica Acta 2010 1801 3 252 265 2-s2.0-76049095119 10.1016/j.bbalip.2009.09.015
    • (2010) Biochimica et Biophysica Acta , vol.1801 , Issue.3 , pp. 252-265
    • Chavez, J.A.1    Summers, S.A.2
  • 6
    • 41149159084 scopus 로고    scopus 로고
    • Insulin resistance and hyperinsulinemia: Is hyperinsulinemia the cart or the horse?
    • supplement 2 2-s2.0-41149159084
    • Shanik M. H., Xu Y., Skrha J., Dankner R., Zick Y., Roth J., Insulin resistance and hyperinsulinemia: is hyperinsulinemia the cart or the horse? Diabetes Care 2008 31 supplement 2 S262 S268 2-s2.0-41149159084
    • (2008) Diabetes Care , vol.31
    • Shanik, M.H.1    Xu, Y.2    Skrha, J.3    Dankner, R.4    Zick, Y.5    Roth, J.6
  • 7
    • 75749145810 scopus 로고    scopus 로고
    • Survival as a function of HbA1c in people with type 2 diabetes: A retrospective cohort study
    • 2-s2.0-75749145810 10.1016/S0140-6736(09)61969-3
    • Currie C. J., Peters J. R., Tynan A., Evans M., Heine R. J., Bracco O. L., Zagar T., Poole C. D., Survival as a function of HbA1c in people with type 2 diabetes: a retrospective cohort study. The Lancet 2010 375 9713 481 489 2-s2.0-75749145810 10.1016/S0140-6736(09)61969-3
    • (2010) The Lancet , vol.375 , Issue.9713 , pp. 481-489
    • Currie, C.J.1    Peters, J.R.2    Tynan, A.3    Evans, M.4    Heine, R.J.5    Bracco, O.L.6    Zagar, T.7    Poole, C.D.8
  • 8
    • 0023191508 scopus 로고
    • Insulin resistance in essential hypertension
    • Ferrannini E., Buzzigoli G., Bonadonna R., Giorico M. A., Oleggini M., Graziadei L., Pedrinelli R., Brandi L., Bevilacqua S., Insulin resistance in essential hypertension. The New England Journal of Medicine 1987 317 6 350 357 (Pubitemid 17118813)
    • (1987) New England Journal of Medicine , vol.317 , Issue.6 , pp. 350-357
    • Ferrannini, E.1    Buzzigoli, G.2    Bonadonna, R.3
  • 9
    • 33845490856 scopus 로고    scopus 로고
    • Review: The role of insulin resistance in nonalcoholic fatty liver disease
    • DOI 10.1210/jc.2006-0587
    • Utzschneider K. M., Kahn S. E., Review: the role of insulin resistance in nonalcoholic fatty liver disease. The Journal of Clinical Endocrinology and Metabolism 2006 91 12 4753 4761 2-s2.0-33845490856 10.1210/jc.2006-0587 (Pubitemid 44917301)
    • (2006) Journal of Clinical Endocrinology and Metabolism , vol.91 , Issue.12 , pp. 4753-4761
    • Utzschneider, K.M.1    Kahn, S.E.2
  • 10
    • 80053616691 scopus 로고    scopus 로고
    • Sphingolipids and hepatic steatosis
    • 2-s2.0-80053616691 10.1007/978-1-4614-0650-1-6
    • Bikman B. T., Summers S. A., Sphingolipids and hepatic steatosis. Advances in Experimental Medicine and Biology 2011 721 87 97 2-s2.0-80053616691 10.1007/978-1-4614-0650-1-6
    • (2011) Advances in Experimental Medicine and Biology , vol.721 , pp. 87-97
    • Bikman, B.T.1    Summers, S.A.2
  • 11
    • 0031456016 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis
    • DOI 10.1210/er.18.6.774
    • Dunaif A., Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocrine Reviews 1997 18 6 774 800 (Pubitemid 28009567)
    • (1997) Endocrine Reviews , vol.18 , Issue.6 , pp. 774-800
    • Dunaif, A.1
  • 12
    • 0037221379 scopus 로고    scopus 로고
    • The role of insulin resistance in the pathogenesis of Alzheimer's disease: Implications for treatment
    • DOI 10.2165/00023210-200317010-00003
    • Watson G. S., Craft S., The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment. CNS Drugs 2003 17 1 27 45 2-s2.0-0037221379 10.2165/00023210-200317010-00003 (Pubitemid 36044347)
    • (2003) CNS Drugs , vol.17 , Issue.1 , pp. 27-45
    • Watson, G.S.1    Craft, S.2
  • 13
    • 3142766836 scopus 로고    scopus 로고
    • Insulin resistance in patients with hypertrophic cardiomyopthy
    • DOI 10.1253/circj.68.650
    • Murakami K., Shigematsu Y., Hamada M., Higaki J., Insulin resistance in patients with hypertrophic cardiomyopthy. Circulation Journal 2004 68 7 650 655 2-s2.0-3142766836 10.1253/circj.68.650 (Pubitemid 38906627)
    • (2004) Circulation Journal , vol.68 , Issue.7 , pp. 650-655
    • Murakami, K.1    Shigematsu, Y.2    Hamada, M.3    Higaki, J.4
  • 14
    • 30844447721 scopus 로고    scopus 로고
    • Insulin resistance: A contributing factor to age-related muscle mass loss?
    • 2-s2.0-30844447721
    • Guillet C., Boirie Y., Insulin resistance: a contributing factor to age-related muscle mass loss? Diabetes & Metabolism 2005 31 2 S20 S26 2-s2.0-30844447721
    • (2005) Diabetes & Metabolism , vol.31 , Issue.2
    • Guillet, C.1    Boirie, Y.2
  • 15
    • 0026021161 scopus 로고
    • Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease
    • 2-s2.0-0026021161
    • DeFronzo R. A., Ferrannini E., Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991 14 3 173 194 2-s2.0-0026021161
    • (1991) Diabetes Care , vol.14 , Issue.3 , pp. 173-194
    • Defronzo, R.A.1    Ferrannini, E.2
  • 16
    • 63249117466 scopus 로고    scopus 로고
    • Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance
    • 2-s2.0-63249117466 10.2337/db08-1228
    • Haus J. M., Kashyap S. R., Kasumov T., Zhang R., Kelly K. R., Defronzo R. A., Kirwan J. P., Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance. Diabetes 2009 58 2 337 343 2-s2.0-63249117466 10.2337/db08-1228
    • (2009) Diabetes , vol.58 , Issue.2 , pp. 337-343
    • Haus, J.M.1    Kashyap, S.R.2    Kasumov, T.3    Zhang, R.4    Kelly, K.R.5    Defronzo, R.A.6    Kirwan, J.P.7
  • 18
    • 38349051098 scopus 로고    scopus 로고
    • Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: Consequences to morphology and viability on enzyme suppression in cultured primary neurons
    • 2-s2.0-38349051098 10.1016/j.brainres.2007.10.066
    • Marks N., Berg M. J., Saito M., Saito M., Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: consequences to morphology and viability on enzyme suppression in cultured primary neurons. Brain Research 2008 1191 136 147 2-s2.0-38349051098 10.1016/j.brainres.2007.10.066
    • (2008) Brain Research , vol.1191 , pp. 136-147
    • Marks, N.1    Berg, M.J.2    Saito, M.3    Saito, M.4
  • 24
    • 80555124939 scopus 로고    scopus 로고
    • Ceramides as modulators of cellular and whole-body metabolism
    • 2-s2.0-80555124939 10.1172/JCI57144
    • Bikman B. T., Summers S. A., Ceramides as modulators of cellular and whole-body metabolism. The Journal of Clinical Investigation 2011 121 11 4222 4230 2-s2.0-80555124939 10.1172/JCI57144
    • (2011) The Journal of Clinical Investigation , vol.121 , Issue.11 , pp. 4222-4230
    • Bikman, B.T.1    Summers, S.A.2
  • 25
    • 84862849621 scopus 로고    scopus 로고
    • A role for sphingolipids in the pathophysiology of obesity-induced inflammation. Cellular and molecular life sciences
    • 10.1007/s00018-012-0917-5
    • Bikman B. T., A role for sphingolipids in the pathophysiology of obesity-induced inflammation. Cellular and molecular life sciences. Cellular and Molecular Life Sciences 2012 69 13 2135 2146 10.1007/s00018-012-0917-5
    • (2012) Cellular and Molecular Life Sciences , vol.69 , Issue.13 , pp. 2135-2146
    • Bikman, B.T.1
  • 27
    • 0036259860 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein-1c expression and action in rat muscles: Insulin-like effects on the control of glycolytic and lipogenic enzymes and UCP3 gene expression
    • Guillet-Deniau I., Mieulet V., Lay S. L., Achouri Y., Carré D., Girard J., Foufelle F., Ferré P., Sterol regulatory element binding protein-1c expression and action in rat muscles: Insulin-like effects on the control of glycolytic and lipogenic enzymes and UCP3 gene expression. Diabetes 2002 51 6 1722 1728 2-s2.0-0036259860 (Pubitemid 34564283)
    • (2002) Diabetes , vol.51 , Issue.6 , pp. 1722-1728
    • Guillet-Deniau, I.1    Mieulet, V.2    Lay, S.L.3    Achouri, Y.4    Carre, D.5    Girard, J.6    Foufelle, F.7    Ferre, P.8
  • 28
    • 34249279490 scopus 로고    scopus 로고
    • Animal models in type 2 diabetes research: An overview
    • Srinivasan K., Ramarao P., Animal models in type 2 diabetes research: an overview. The Indian Journal of Medical Research 2007 125 3 451 472 2-s2.0-34249279490 (Pubitemid 46805458)
    • (2007) Indian Journal of Medical Research , vol.125 , Issue.3 , pp. 451-472
    • Srinivasan, K.1    Ramarao, P.2
  • 29
    • 0032702547 scopus 로고    scopus 로고
    • Changes in plasma free fatty acid concentrations in rheumatoid arthritis patients during fasting and their effects upon T-lymphocyte proliferation
    • DOI 10.1093/rheumatology/38.10.948
    • Fraser D. A., Thoen J., Rustan A. C., Førre Ø., Kjeldsen-Kragh J., Changes in plasma free fatty acid concentrations in rheumatoid arthritis patients during fasting and their effects upon T-lymphocyte proliferation. Rheumatology 1999 38 10 948 952 2-s2.0-0032702547 10.1093/rheumatology/38.10.948 (Pubitemid 29505075)
    • (1999) Rheumatology , vol.38 , Issue.10 , pp. 948-952
    • Fraser, D.A.1    Thoen, J.2    Rustan, A.C.3    Forre, O.4    Kjeldsen-Kragh, J.5
  • 32
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • 2-s2.0-17344392308
    • Pfaffl M. W., A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Research 2001 29 9, article e45 2-s2.0-17344392308
    • (2001) Nucleic Acids Research , vol.29 , Issue.9 ARTICLE E45
    • Pfaffl, M.W.1
  • 34
    • 0346729968 scopus 로고    scopus 로고
    • Ceramide content is increased in skeletal muscle from obese insulin-resistant humans
    • DOI 10.2337/diabetes.53.1.25
    • Adams J. M. II, Pratipanawatr T., Berria R., Wang E., DeFronzo R. A., Sullards M. C., Mandarino L. J., Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. Diabetes 2004 53 1 25 31 2-s2.0-0346729968 10.2337/diabetes.53.1.25 (Pubitemid 38044694)
    • (2004) Diabetes , vol.53 , Issue.1 , pp. 25-31
    • Adams II, J.M.1    Pratipanawatr, T.2    Berria, R.3    Wang, E.4    DeFronzo, R.A.5    Sullards, M.C.6    Mandarino, L.J.7
  • 36
    • 77449161528 scopus 로고    scopus 로고
    • Insulin resistance is associated with higher intramyocellular triglycerides in type i but not type II myocytes concomitant with higher ceramide content
    • 2-s2.0-77449161528 10.2337/db09-0988
    • Coen P. M., Dubé J. J., Amati F., Stefanovic-Racic M., Ferrell R. E., Toledo F. G. S., Goodpaster B. H., Insulin resistance is associated with higher intramyocellular triglycerides in type I but not type II myocytes concomitant with higher ceramide content. Diabetes 2010 59 1 80 88 2-s2.0-77449161528 10.2337/db09-0988
    • (2010) Diabetes , vol.59 , Issue.1 , pp. 80-88
    • Coen, P.M.1    Dubé, J.J.2    Amati, F.3    Stefanovic-Racic, M.4    Ferrell, R.E.5    Toledo, F.G.S.6    Goodpaster, B.H.7
  • 37
    • 0038532298 scopus 로고    scopus 로고
    • A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids
    • DOI 10.1074/jbc.M212307200
    • Chavez J. A., Knotts T. A., Wang L.-P., Li G., Dobrowsky R. T., Florant G. L., Summers S. A., A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. The Journal of Biological Chemistry 2003 278 12 10297 10303 2-s2.0-0038532298 10.1074/jbc.M212307200 (Pubitemid 36800291)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.12 , pp. 10297-10303
    • Chavez, J.A.1    Knotts, T.A.2    Wang, L.-P.3    Li, G.4    Dobrowsky, R.T.5    Florant, G.L.6    Summers, S.A.7
  • 38
    • 0033588253 scopus 로고    scopus 로고
    • Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
    • DOI 10.1074/jbc.274.34.24202
    • Schmitz-Peiffer C., Craig D. L., Biden T. J., Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. The Journal of Biological Chemistry 1999 274 34 24202 24210 2-s2.0-0033588253 10.1074/jbc.274.34.24202 (Pubitemid 29390356)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.34 , pp. 24202-24210
    • Schmitz-Peiffer, C.1    Craig, D.L.2    Biden, T.J.3
  • 42
    • 0035217707 scopus 로고    scopus 로고
    • Skeletal muscle lipid content and insulin resistance: Evidence for a paradox in endurance-trained athletes
    • DOI 10.1210/jc.86.12.5755
    • Goodpaster B. H., He J., Watkins S., Kelley D. E., Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. The Journal of Clinical Endocrinology and Metabolism 2001 86 12 5755 5761 2-s2.0-0035217707 10.1210/jc.86.12.5755 (Pubitemid 33152620)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , Issue.12 , pp. 5755-5761
    • Goodpaster, B.H.1    He, J.2    Watkins, S.3    Kelley, D.E.4
  • 43
    • 34249894505 scopus 로고    scopus 로고
    • Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance
    • DOI 10.1172/JCI30565
    • Liu L., Zhang Y., Chen N., Shi X., Tsang B., Yu Y.-H., Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. The Journal of Clinical Investigation 2007 117 6 1679 1689 2-s2.0-34249894505 10.1172/JCI30565 (Pubitemid 46871352)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.6 , pp. 1679-1689
    • Liu, L.1    Zhang, Y.2    Chen, N.3    Shi, X.4    Tsang, B.5    Yu, Y.-H.6
  • 45
    • 77649264504 scopus 로고    scopus 로고
    • Bifurcation of insulin signaling pathway in rat liver: MTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
    • 2-s2.0-77649264504 10.1073/pnas.0914798107
    • Li S., Brown M. S., Goldstein J. L., Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proceedings of the National Academy of Sciences of the United States of America 2010 107 8 3441 3446 2-s2.0-77649264504 10.1073/pnas.0914798107
    • (2010) Proceedings of the National Academy of Sciences of the United States of America , vol.107 , Issue.8 , pp. 3441-3446
    • Li, S.1    Brown, M.S.2    Goldstein, J.L.3
  • 46
    • 0034891371 scopus 로고    scopus 로고
    • Insulin resistance as a predictor of age-related diseases
    • DOI 10.1210/jc.86.8.3574
    • Facchini F. S., Hua N., Abbasi F., Reaven G. M., Insulin resistance as a predictor of age-related diseases. The Journal of Clinical Endocrinology and Metabolism 2001 86 8 3574 3578 2-s2.0-0034891371 10.1210/jc.86.8.3574 (Pubitemid 32755946)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , Issue.8 , pp. 3574-3578
    • Facchini, F.S.1    Hua, N.2    Abbasi, F.3    Reaven, G.M.4
  • 47
    • 0018140662 scopus 로고
    • Prognosis of diabetics with diabetes onset before the age of thirtyone. II. Factors influencing the prognosis
    • Deckert T., Poulsen J. E., Larsen M., Prognosis of diabetics with diabetes onset before the age of thirtyone. II. Factors influencing the prognosis. Diabetologia 1978 14 6 371 377 2-s2.0-0018140662 (Pubitemid 8357141)
    • (1978) Diabetologia , vol.14 , Issue.6 , pp. 371-377
    • Deckert, T.1    Poulsen, J.E.2    Larsen, M.3
  • 48
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α- and obesity-induced insulin resistance
    • Hotamisligil G. S., Peraldi P., Budavari A., Ellis R., White M. F., Spiegelman B. M., IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 1996 271 5249 665 668 10.1126/science.271.5249.665 (Pubitemid 26052915)
    • (1996) Science , vol.271 , Issue.5249 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 49
    • 0013102988 scopus 로고    scopus 로고
    • Suppression of insulin secretion is associated with weight loss and altered macronutrient intake and preference in a subset of obese adults
    • DOI 10.1038/sj.ijo.802227
    • Velasquez-Mieyer P. A., Cowan P. A., Arheart K. L., Buffington C. K., Spencer K. A., Connelly B. E., Cowan G. W., Lustig R. H., Suppression of insulin secretion is associated with weight loss and altered macronutrient intake and preference in a subset of obese adults. International Journal of Obesity 2003 27 2 219 226 2-s2.0-0013102988 10.1038/sj.ijo.802227 (Pubitemid 36255804)
    • (2003) International Journal of Obesity , vol.27 , Issue.2 , pp. 219-226
    • Velasquez-Mieyer, P.A.1    Cowan, P.A.2    Arheart, K.L.3    Buffington, C.K.4    Spencer, K.A.5    Connelly, B.E.6    Cowan, G.W.7    Lustig, R.H.8
  • 50
    • 0021330994 scopus 로고
    • Hyperinsulinemia in rats with ventromedial hypothalamic lesions: Role of hyperphagia
    • DOI 10.1037//0735-7044.98.1.152
    • King B. M., Smith R. L., Frohman L. A., Hyperinsulinemia in rats with ventromedial hypothalamic lesions: role of hyperphagia. Behavioral Neuroscience 1984 98 1 152 155 2-s2.0-0021330994 10.1037//0735-7044.98.1.152 (Pubitemid 14174065)
    • (1984) Behavioral Neuroscience , vol.98 , Issue.1 , pp. 152-155
    • King, B.M.1    Smith, R.L.2    Frohman, L.A.3
  • 51
    • 0015266939 scopus 로고
    • Correlation between hyperinsulinemia and hyperphagia in rats with ventromedial hypothalamic lesions
    • 2-s2.0-0015266939
    • Hustvedt B. E., Lovo A., Correlation between hyperinsulinemia and hyperphagia in rats with ventromedial hypothalamic lesions. Acta Physiologica Scandinavica 1972 84 1 29 33 2-s2.0-0015266939
    • (1972) Acta Physiologica Scandinavica , vol.84 , Issue.1 , pp. 29-33
    • Hustvedt, B.E.1    Lovo, A.2
  • 52
    • 0027517779 scopus 로고
    • Intensive insulin therapy and weight gain in IDDM
    • Carlson M. G., Campbell P. J., Intensive insulin therapy and weight gain in IDDM. Diabetes 1993 42 12 1700 1707 2-s2.0-0027517779 (Pubitemid 23346405)
    • (1993) Diabetes , vol.42 , Issue.12 , pp. 1700-1707
    • Carlson, M.G.1    Campbell, P.J.2
  • 53
    • 0344609217 scopus 로고    scopus 로고
    • Causes of weight gain during insulin therapy with and without metformin in patients with Type II diabetes mellitus
    • DOI 10.1007/s001250051172
    • Mäkimattila S., Nikkilä K., Yki-Järvinen H., Causes of weight gain during insulin therapy with and without metformin in patients with Type II diabetes mellitus. Diabetologia 1999 42 4 406 412 2-s2.0-0344609217 10.1007/s001250051172 (Pubitemid 29148398)
    • (1999) Diabetologia , vol.42 , Issue.4 , pp. 406-412
    • Makimattila, S.1    Nikkila, K.2    Yki-Jarvinen, H.3
  • 55
    • 0017578054 scopus 로고
    • Development of obesity in diabetic mice pair fed with lean siblings
    • Cox J. E., Powley T. L., Development of obesity in diabetic mice pair fed with lean siblings. Journal of Comparative and Physiological Psychology 1977 91 2 347 358 2-s2.0-0017578054 (Pubitemid 8087578)
    • (1977) Journal of Comparative and Physiological Psychology , vol.91 , Issue.2 , pp. 347-358
    • Cox, J.E.1    Powley, T.L.2
  • 56
    • 60449089649 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • 10.2337/dc08-9025
    • Nathan D. M., Buse J. B., Davidson M. B., Ferrannini E., Holman R. R., Sherwin R., Zinman B., American Diabetes A., Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2009 32 1 193 203 10.2337/dc08-9025
    • (2009) Diabetes Care , vol.32 , Issue.1 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3    Ferrannini, E.4    Holman, R.R.5    Sherwin, R.6    Zinman, B.7    American Diabetes, A.8
  • 57
    • 75149130955 scopus 로고    scopus 로고
    • Diagnosis and classification of diabetes mellitus
    • supplement 1 10.2337/dc10-S062
    • American Diabetes Association, Diagnosis and classification of diabetes mellitus. Diabetes Care 2010 33 supplement 1 S62 S69 10.2337/dc10-S062
    • (2010) Diabetes Care , vol.33
  • 58
    • 30344462964 scopus 로고    scopus 로고
    • A low-carbohydrate, ketogenic diet to treat type 2 diabetes
    • DOI 10.1186/1743-7075-2-34
    • Yancy W. S. Jr., Foy M., Chalecki A. M., Vernon M. C., Westman E. C., A low-carbohydrate, ketogenic diet to treat type 2 diabetes. Nutrition & Metabolism 2005 2, article 34 2-s2.0-30344462964 10.1186/1743-7075-2-34 (Pubitemid 43060608)
    • (2005) Nutrition and Metabolism , vol.2 , pp. 34
    • Yancy Jr., W.S.1    Foy, M.2    Chalecki, A.M.3    Vernon, M.C.4    Westman, E.C.5
  • 59
    • 0014433315 scopus 로고
    • Insulin-stimulated lipogenesis in arterial tissue in relation to diabetes and atheroma
    • 2-s2.0-0014433315
    • Stout R. W., Insulin-stimulated lipogenesis in arterial tissue in relation to diabetes and atheroma. The Lancet 1968 2 7570 702 703 2-s2.0-0014433315
    • (1968) The Lancet , vol.2 , Issue.7570 , pp. 702-703
    • Stout, R.W.1
  • 60
    • 38349092384 scopus 로고    scopus 로고
    • Ceramide: A common pathway for atherosclerosis?
    • 2-s2.0-38349092384 10.1016/j.atherosclerosis.2007.09.018
    • Bismuth J., Lin P., Yao Q., Chen C., Ceramide: a common pathway for atherosclerosis? Atherosclerosis 2008 196 2 497 504 2-s2.0-38349092384 10.1016/j.atherosclerosis.2007.09.018
    • (2008) Atherosclerosis , vol.196 , Issue.2 , pp. 497-504
    • Bismuth, J.1    Lin, P.2    Yao, Q.3    Chen, C.4
  • 61
    • 0030025673 scopus 로고    scopus 로고
    • Hypertension and associated metabolic abnormalities - The role of insulin resistance and the sympathoadrenal system
    • DOI 10.1056/NEJM199602083340607
    • Reaven G. M., Lithell H., Landsberg L., Hypertension and associated metabolic abnormalities-the role of insulin resistance and the sympathoadrenal system. The New England Journal of Medicine 1996 334 6 374 381 10.1056/NEJM199602083340607 (Pubitemid 26049592)
    • (1996) New England Journal of Medicine , vol.334 , Issue.6 , pp. 374-381
    • Reaven, G.M.1    Lithell, H.2    Landsberg, L.3
  • 62
    • 0035957592 scopus 로고    scopus 로고
    • Ceramide reduces endothelium-dependent vasodilation by increasing superoxide production in small bovine coronary arteries
    • Zhang D. X., Zou A.-P., Li P.-L., Ceramide reduces endothelium-dependent vasodilation by increasing superoxide production in small bovine coronary arteries. Circulation Research 2001 88 8 824 831 2-s2.0-0035957592 (Pubitemid 32429979)
    • (2001) Circulation Research , vol.88 , Issue.8 , pp. 824-831
    • Zhang, D.X.1    Zou, A.-P.2    Li, P.-L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.