Control of catalytic efficiency by a coevolving network of catalytic and noncatalytic residues

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 23, 2014, Pages

  McMurrough, Thomas A ^a   Dickson, Russell J ^a   Thibert, Stephanie M F ^a   Gloor, Gregory B ^a   Edgell, David R ^a  

^a WESTERN UNIVERSITY   (Canada)

Author keywords

Amino acid coevolution; Genetic selection

Indexed keywords

AMINO ACID; ENDONUCLEASE; OLIGONUCLEOTIDE; PLASMID DNA;

ARTICLE; BACTERIAL GROWTH; BINDING SITE; CATALYSIS; COEVOLUTION; DIFFERENTIAL SCANNING CALORIMETRY; ENZYME ACTIVITY; GENETIC SELECTION; IN VITRO STUDY; METAL BINDING; MUTANT; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY;

AMINO ACID COEVOLUTION; GENETIC SELECTION;

ASPARTIC ACID; BINDING SITES; BIOCATALYSIS; CATALYTIC DOMAIN; ENDONUCLEASES; EVOLUTION, MOLECULAR; GLUTAMIC ACID; MODELS, GENETIC; MODELS, MOLECULAR; MUTATION; PHYLOGENY; PROTEIN STRUCTURE, TERTIARY;

EID: 84902204278     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1322352111     Document Type: Article

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