-
1
-
-
52649109068
-
The TRAIL apoptotic pathway in cancer onset, progression, and therapy
-
Johnstone, R. W., Frew, A. J., and Smyth, M. J. (2008) The TRAIL apoptotic pathway in cancer onset, progression, and therapy. Nat. Rev. Cancer 8, 782-798
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 782-798
-
-
Johnstone, R.W.1
Frew, A.J.2
Smyth, M.J.3
-
2
-
-
16644372319
-
Following a TRAIL: Update on a ligand and its five receptors
-
Kimberley, F. C., and Screaton, G. R. (2004) Following a TRAIL: update on a ligand and its five receptors. Cell Res. 14, 359-372
-
(2004)
Cell Res.
, vol.14
, pp. 359-372
-
-
Kimberley, F.C.1
Screaton, G.R.2
-
3
-
-
79951842931
-
Anticancer efficacy of Apo2L/TRAIL is retained in the presence of high and biologically active concentrations of osteoprotegerin in vivo
-
Zinonos, I., Labrinidis, A., Lee, M., Liapis, V., Hay, S., Ponomarev, V., Diamond, P., Findlay, D. M., Zannettino, A. C., and Evdokiou, A. (2011) Anticancer efficacy of Apo2L/TRAIL is retained in the presence of high and biologically active concentrations of osteoprotegerin in vivo. J. Bone Miner. Res. 26, 630-643
-
(2011)
J. Bone Miner. Res.
, vol.26
, pp. 630-643
-
-
Zinonos, I.1
Labrinidis, A.2
Lee, M.3
Liapis, V.4
Hay, S.5
Ponomarev, V.6
Diamond, P.7
Findlay, D.M.8
Zannettino, A.C.9
Evdokiou, A.10
-
4
-
-
51049114701
-
OPG is regulated byβ-catenin and mediates resistance to TRAIL-induced apoptosis in colon cancer
-
De Toni, E. N., Thieme, S. E., Herbst, A., Behrens, A., Stieber, P., Jung, A., Blum, H., Göke, B., and Kolligs, F. T. (2008) OPG is regulated byβ-catenin and mediates resistance to TRAIL-induced apoptosis in colon cancer. Clin. Cancer Res. 14, 4713-4718
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 4713-4718
-
-
De Toni, E.N.1
Thieme, S.E.2
Herbst, A.3
Behrens, A.4
Stieber, P.5
Jung, A.6
Blum, H.7
Göke, B.8
Kolligs, F.T.9
-
5
-
-
28844441555
-
Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand
-
Varfolomeev, E., Maecker, H., Sharp, D., Lawrence, D., Renz, M., Vucic, D., and Ashkenazi, A. (2005) Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand. J. Biol. Chem. 280, 40599-40608
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 40599-40608
-
-
Varfolomeev, E.1
Maecker, H.2
Sharp, D.3
Lawrence, D.4
Renz, M.5
Vucic, D.6
Ashkenazi, A.7
-
6
-
-
33750370438
-
Distinct signaling pathways in TRAILversus tumor necrosis factor-induced apoptosis
-
Jin, Z., and El-Deiry, W. S. (2006) Distinct signaling pathways in TRAILversus tumor necrosis factor-induced apoptosis. Mol. Cell. Biol. 26, 8136-8148
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 8136-8148
-
-
Jin, Z.1
El-Deiry, W.S.2
-
7
-
-
17044382532
-
Homomeric and heteromeric interactions of the extracellular domains of death receptors and death decoy receptors
-
Lee, H. W., Lee, S. H., Lee, H. W., Ryu, Y. W., Kwon, M. H., and Kim, Y. S. (2005) Homomeric and heteromeric interactions of the extracellular domains of death receptors and death decoy receptors. Biochem. Biophys. Res. Commun. 330, 1205-1212
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.330
, pp. 1205-1212
-
-
Lee, H.W.1
Lee, S.H.2
Lee, H.W.3
Ryu, Y.W.4
Kwon, M.H.5
Kim, Y.S.6
-
8
-
-
0031414749
-
The novel receptor TRAIL-R4 induces NF-βB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain
-
Degli-Esposti, M. A., Dougall, W. C., Smolak, P. J., Waugh, J. Y., Smith, C. A., and Goodwin, R. G. (1997) The novel receptor TRAIL-R4 induces NF-βB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity 7, 813-820
-
(1997)
Immunity
, vol.7
, pp. 813-820
-
-
Degli-Esposti, M.A.1
Dougall, W.C.2
Smolak, P.J.3
Waugh, J.Y.4
Smith, C.A.5
Goodwin, R.G.6
-
9
-
-
0034725664
-
Temperaturesensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor
-
Truneh, A., Sharma, S., Silverman, C., Khandekar, S., Reddy, M. P., Deen, K. C., McLaughlin, M. M., Srinivasula, S. M., Livi, G. P., Marshall, L. A., Alnemri, E. S., Williams, W. V., and Doyle, M. L. (2000) Temperaturesensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor. J. Biol. Chem. 275, 23319-23325
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 23319-23325
-
-
Truneh, A.1
Sharma, S.2
Silverman, C.3
Khandekar, S.4
Reddy, M.P.5
Deen, K.C.6
McLaughlin, M.M.7
Srinivasula, S.M.8
Livi, G.P.9
Marshall, L.A.10
Alnemri, E.S.11
Williams, W.V.12
Doyle, M.L.13
-
10
-
-
0030762815
-
An antagonist decoy receptor and a death domain-containing receptor for TRAIL
-
Pan, G., Ni, J., Wei, Y.-F., Yu, G.-l., Gentz, R., and Dixit, V. M. (1997) An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277, 815-818
-
(1997)
Science
, vol.277
, pp. 815-818
-
-
Pan, G.1
Ni, J.2
Wei, Y.-F.3
Yu, G.-L.4
Gentz, R.5
Dixit, V.M.6
-
11
-
-
0030869432
-
Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family
-
Degli-Esposti, M. A., Smolak, P. J., Walczak, H., Waugh, J., Huang, C. P., DuBose, R. F., Goodwin, R. G., and Smith, C. A. (1997) Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. J. Exp. Med. 186, 1165-1170
-
(1997)
J. Exp. Med.
, vol.186
, pp. 1165-1170
-
-
Degli-Esposti, M.A.1
Smolak, P.J.2
Walczak, H.3
Waugh, J.4
Huang, C.P.5
DuBose, R.F.6
Goodwin, R.G.7
Smith, C.A.8
-
12
-
-
0033212968
-
Triggering cell death: The crystal structure of apo2L/TRAIL in a complex with death receptor 5
-
Hymowitz, S. G., Christinger, H. W., Fuh, G., Ultsch, M., O'Connell, M., Kelley, R. F., Ashkenazi, A., and de Vos, A. M. (1999) Triggering cell death: the crystal structure of apo2L/TRAIL in a complex with death receptor 5. Mol. Cell 4, 563-571
-
(1999)
Mol. Cell
, vol.4
, pp. 563-571
-
-
Hymowitz, S.G.1
Christinger, H.W.2
Fuh, G.3
Ultsch, M.4
O'Connell, M.5
Kelley, R.F.6
Ashkenazi, A.7
De Vos, A.M.8
-
13
-
-
0034733682
-
Adomain in TNF receptors that mediates ligand-independent receptor assembly and signaling
-
Chan, F. K., Chun, H. J., Zheng, L., Siegel, R. M., Bui, K. L., and Lenardo, M. J. (2000) Adomain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science 288, 2351-2354
-
(2000)
Science
, vol.288
, pp. 2351-2354
-
-
Chan, F.K.1
Chun, H.J.2
Zheng, L.3
Siegel, R.M.4
Bui, K.L.5
Lenardo, M.J.6
-
14
-
-
0034733584
-
Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations
-
Siegel, R. M., Frederiksen, J. K., Zacharias, D. A., Chan, F. K., Johnson, M., Lynch, D., Tsien, R. Y., and Lenardo, M. J. (2000) Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science 288, 2354-2357
-
(2000)
Science
, vol.288
, pp. 2354-2357
-
-
Siegel, R.M.1
Frederiksen, J.K.2
Zacharias, D.A.3
Chan, F.K.4
Johnson, M.5
Lynch, D.6
Tsien, R.Y.7
Lenardo, M.J.8
-
15
-
-
29144496895
-
Preligand assembly domainmediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis
-
Clancy, L., Mruk, K., Archer, K., Woelfel, M., Mongkolsapaya, J., Screaton, G., Lenardo, M. J., and Chan, F. K. (2005) Preligand assembly domainmediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. Proc. Natl. Acad. Sci. U. S. A. 102, 18099-18104
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 18099-18104
-
-
Clancy, L.1
Mruk, K.2
Archer, K.3
Woelfel, M.4
Mongkolsapaya, J.5
Screaton, G.6
Lenardo, M.J.7
Chan, F.K.8
-
16
-
-
0032750511
-
Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation
-
Mongkolsapaya, J., Grimes, J. M., Chen, N., Xu, X.-N., Stuart, D. I., Jones, E. Y., and Screaton, G. R. (1999) Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation. Nat. Struct. Biol. 6, 1048-1053
-
(1999)
Nat. Struct. Biol.
, vol.6
, pp. 1048-1053
-
-
Mongkolsapaya, J.1
Grimes, J.M.2
Chen, N.3
Xu, X.-N.4
Stuart, D.I.5
Jones, E.Y.6
Screaton, G.R.7
-
17
-
-
33749164762
-
Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2
-
Mérino, D., Lalaoui, N., Morizot, A., Schneider, P., Solary, E., and Micheau, O. (2006) Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol. Cell. Biol. 26, 7046-7055
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 7046-7055
-
-
Mérino, D.1
Lalaoui, N.2
Morizot, A.3
Schneider, P.4
Solary, E.5
Micheau, O.6
-
18
-
-
79956318603
-
TRAIL-R4 promotes tumor growth and resistance to apoptosis in cervical carcinoma HeLa cells through AKT
-
Lalaoui, N., Morlé, A., Mérino, D., Jacquemin, G., Iessi, E., Morizot, A., Shirley, S., Robert, B., Solary, E., Garrido, C., and Micheau, O. (2011) TRAIL-R4 promotes tumor growth and resistance to apoptosis in cervical carcinoma HeLa cells through AKT. PLoS ONE 6, e19679
-
(2011)
PLoS ONE
, vol.6
-
-
Lalaoui, N.1
Morlé, A.2
Mérino, D.3
Jacquemin, G.4
Iessi, E.5
Morizot, A.6
Shirley, S.7
Robert, B.8
Solary, E.9
Garrido, C.10
Micheau, O.11
-
19
-
-
0035860696
-
Modulation of tumor necrosis factor apoptosis-inducing ligandinduced NF-βB activation by inhibition of apical caspases
-
Harper, N., Farrow, S. N., Kaptein, A., Cohen, G. M., and MacFarlane, M. (2001) Modulation of tumor necrosis factor apoptosis-inducing ligandinduced NF-βB activation by inhibition of apical caspases. J. Biol. Chem. 276, 34743-34752
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 34743-34752
-
-
Harper, N.1
Farrow, S.N.2
Kaptein, A.3
Cohen, G.M.4
MacFarlane, M.5
-
20
-
-
71349086770
-
Dual function of cysteine rich domain (CRD) 1 of TNF receptor type 1: Conformational stabilization of CRD2 and control of receptor responsiveness
-
Branschädel, M., Aird, A., Zappe, A., Tietz, C., Krippner-Heidenreich, A., and Scheurich, P. (2010) Dual function of cysteine rich domain (CRD) 1 of TNF receptor type 1: conformational stabilization of CRD2 and control of receptor responsiveness. Cell. Signal. 22, 404-414
-
(2010)
Cell. Signal.
, vol.22
, pp. 404-414
-
-
Branschädel, M.1
Aird, A.2
Zappe, A.3
Tietz, C.4
Krippner-Heidenreich, A.5
Scheurich, P.6
-
21
-
-
77952290633
-
Single chain TNF derivatives with individually mutated receptor binding sites reveal differential stoichiometry of ligand receptor complex formation for TNFR1 and TNFR2
-
Boschert, V., Krippner-Heidenreich, A., Branschädel, M., Tepperink, J., Aird, A., and Scheurich, P. (2010) Single chain TNF derivatives with individually mutated receptor binding sites reveal differential stoichiometry of ligand receptor complex formation for TNFR1 and TNFR2. Cell. Signal. 22, 1088-1096
-
(2010)
Cell. Signal.
, vol.22
, pp. 1088-1096
-
-
Boschert, V.1
Krippner-Heidenreich, A.2
Branschädel, M.3
Tepperink, J.4
Aird, A.5
Scheurich, P.6
-
22
-
-
84864859106
-
A minimal mathematical model for the initial molecular interactions of death receptor signaling
-
Winkel, C., Neumann, S., Surulescu, C., and Scheurich, P. (2012) A minimal mathematical model for the initial molecular interactions of death receptor signaling. Math. Biosci. Eng. 9, 663-683
-
(2012)
Math. Biosci. Eng.
, vol.9
, pp. 663-683
-
-
Winkel, C.1
Neumann, S.2
Surulescu, C.3
Scheurich, P.4
-
23
-
-
77952549882
-
Fluorescence correlation spectroscopy reveals topological segregation of the two tumor necrosis factor membrane receptors
-
Gerken, M., Krippner-Heidenreich, A., Steinert, S., Willi, S., Neugart, F., Zappe, A., Wrachtrup, J., Tietz, C., and Scheurich, P. (2010) Fluorescence correlation spectroscopy reveals topological segregation of the two tumor necrosis factor membrane receptors. Biochim. Biophys. Acta 1798, 1081-1089
-
(2010)
Biochim. Biophys. Acta
, vol.1798
, pp. 1081-1089
-
-
Gerken, M.1
Krippner-Heidenreich, A.2
Steinert, S.3
Willi, S.4
Neugart, F.5
Zappe, A.6
Wrachtrup, J.7
Tietz, C.8
Scheurich, P.9
-
24
-
-
0031020635
-
Bcl-2, Bcl-x (L) and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death
-
Huang, D. C., Cory, S., and Strasser, A. (1997) Bcl-2, Bcl-x (L) and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death. Oncogene 14, 405-414
-
(1997)
Oncogene
, vol.14
, pp. 405-414
-
-
Huang, D.C.1
Cory, S.2
Strasser, A.3
-
25
-
-
0037113868
-
Control of receptor-induced signaling complex formation by the kinetics of ligand/receptor interaction
-
Krippner-Heidenreich, A., Tübing, F., Bryde, S., Willi, S., Zimmermann, G., and Scheurich, P. (2002) Control of receptor-induced signaling complex formation by the kinetics of ligand/receptor interaction. J. Biol. Chem. 277, 44155-44163
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 44155-44163
-
-
Krippner-Heidenreich, A.1
Tübing, F.2
Bryde, S.3
Willi, S.4
Zimmermann, G.5
Scheurich, P.6
-
26
-
-
34250199380
-
FRETcalc plugin for calculation of FRET in noncontinuous intracellular compartments
-
Stepensky, D. (2007) FRETcalc plugin for calculation of FRET in noncontinuous intracellular compartments. Biochem. Biophys. Res. Commun. 359, 752-758
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.359
, pp. 752-758
-
-
Stepensky, D.1
-
27
-
-
0033621336
-
Identification and characterization of a ligandindependent oligomerization domain in the extracellular region of the CD95 death receptor
-
Papoff, G., Hausler, P., Eramo, A., Pagano, M. G., Di Leve, G., Signore, A., and Ruberti, G. (1999) Identification and characterization of a ligandindependent oligomerization domain in the extracellular region of the CD95 death receptor. J. Biol. Chem. 274, 38241-38250
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 38241-38250
-
-
Papoff, G.1
Hausler, P.2
Eramo, A.3
Pagano, M.G.4
Di Leve, G.5
Signore, A.6
Ruberti, G.7
-
28
-
-
84862293697
-
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces death receptor 5 networks that are highly organized
-
Valley, C. C., Lewis, A. K., Mudaliar, D. J., Perlmutter, J. D., Braun, A. R., Karim, C. B., Thomas, D. D., Brody, J. R., and Sachs, J. N. (2012) Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces death receptor 5 networks that are highly organized. J. Biol. Chem. 287, 21265-21278
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 21265-21278
-
-
Valley, C.C.1
Lewis, A.K.2
Mudaliar, D.J.3
Perlmutter, J.D.4
Braun, A.R.5
Karim, C.B.6
Thomas, D.D.7
Brody, J.R.8
Sachs, J.N.9
-
29
-
-
84865411840
-
TNFR1 signaling is associated with backbone conformational changes of receptor dimers consistent with overactivation in the R92Q TRAPS mutant
-
Lewis, A. K., Valley, C. C., and Sachs, J. N. (2012) TNFR1 signaling is associated with backbone conformational changes of receptor dimers consistent with overactivation in the R92Q TRAPS mutant. Biochemistry 51, 6545-6555
-
(2012)
Biochemistry
, vol.51
, pp. 6545-6555
-
-
Lewis, A.K.1
Valley, C.C.2
Sachs, J.N.3
-
30
-
-
77956170550
-
New insights into apoptosis signaling by Apo2L/TRAIL
-
Gonzalvez, F., and Ashkenazi, A. (2010) New insights into apoptosis signaling by Apo2L/TRAIL. Oncogene 29, 4752-4765
-
(2010)
Oncogene
, vol.29
, pp. 4752-4765
-
-
Gonzalvez, F.1
Ashkenazi, A.2
-
31
-
-
84880271502
-
Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: Discord in the death receptor family
-
Azijli, K., Weyhenmeyer, B., Peters, G. J., de Jong, S., and Kruyt, F. A. (2013) Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family. Cell. Death. Differ. 20, 858-868
-
(2013)
Cell. Death. Differ.
, vol.20
, pp. 858-868
-
-
Azijli, K.1
Weyhenmeyer, B.2
Peters, G.J.3
De Jong, S.4
Kruyt, F.A.5
-
32
-
-
84864018997
-
The tumor necrosis factor receptor stalk regions define responsiveness to soluble versus membrane-bound ligand
-
Richter, C., Messerschmidt, S., Holeiter, G., Tepperink, J., Osswald, S., Zappe, A., Branschädel, M., Boschert, V., Mann, D. A., Scheurich, P., and Krippner-Heidenreich, A. (2012) The tumor necrosis factor receptor stalk regions define responsiveness to soluble versus membrane-bound ligand. Mol. Cell. Biol. 32, 2515-2529
-
(2012)
Mol. Cell. Biol.
, vol.32
, pp. 2515-2529
-
-
Richter, C.1
Messerschmidt, S.2
Holeiter, G.3
Tepperink, J.4
Osswald, S.5
Zappe, A.6
Branschädel, M.7
Boschert, V.8
Mann, D.A.9
Scheurich, P.10
Krippner-Heidenreich, A.11
-
33
-
-
50649111704
-
DR4-selective tumor necrosis factorrelated apoptosis-inducing ligand (TRAIL) variants obtained by structurebased design
-
Tur, V., van der Sloot, A. M., Reis, C. R., Szegezdi, E., Cool, R. H., Samali, A., Serrano, L., and Quax, W. J. (2008) DR4-selective tumor necrosis factorrelated apoptosis-inducing ligand (TRAIL) variants obtained by structurebased design. J. Biol. Chem. 283, 20560-20568
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 20560-20568
-
-
Tur, V.1
Van Der Sloot, A.M.2
Reis, C.R.3
Szegezdi, E.4
Cool, R.H.5
Samali, A.6
Serrano, L.7
Quax, W.J.8
-
34
-
-
0032697485
-
Tumor necrosis factorrelated apoptosis-inducing ligand receptors signal NF-βB and JNK activation and apoptosis through distinct pathways
-
Hu, W.-H., Johnson, H., and Shu, H.-B. (1999) Tumor necrosis factorrelated apoptosis-inducing ligand receptors signal NF-βB and JNK activation and apoptosis through distinct pathways. J. Biol. Chem. 274, 30603-30610
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 30603-30610
-
-
Hu, W.-H.1
Johnson, H.2
Shu, H.-B.3
-
35
-
-
0034136792
-
The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis
-
Meng, R. D., McDonald, E. R., 3rd., Sheikh, M. S., Fornace, A. J., Jr., and El-Deiry, W. S. (2000) The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis. Mol. Ther. 1, 130-144
-
(2000)
Mol. Ther.
, vol.1
, pp. 130-144
-
-
Meng, R.D.1
McDonald III, E.R.2
Sheikh, M.S.3
Fornace Jr., A.J.4
El-Deiry, W.S.5
-
36
-
-
13144265771
-
A novel receptor for Apo2L/TRAIL contains a truncated death domain
-
Marsters, S. A., Sheridan, J. P., Pitti, R. M., Huang, A., Skubatch, M., Baldwin, D., Yuan, J., Gurney, A., Goddard, A. D., Godowski, P., and Ashkenazi, A. (1997) A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr. Biol. 7, 1003-1006
-
(1997)
Curr. Biol.
, vol.7
, pp. 1003-1006
-
-
Marsters, S.A.1
Sheridan, J.P.2
Pitti, R.M.3
Huang, A.4
Skubatch, M.5
Baldwin, D.6
Yuan, J.7
Gurney, A.8
Goddard, A.D.9
Godowski, P.10
Ashkenazi, A.11
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