A synthetic dinuclear copper(II) hydrolase and its potential as antitumoral: Cytotoxicity, cellular uptake, and DNA cleavage

Journal of Inorganic Biochemistry

Volumn 103, Issue 10, 2009, Pages 1323-1330

  Rey, Nicolás A ^a   Neves, Ademir ^a   Silva, Priscila P ^b   Paula, Flávia C S ^b   Silveira, Josianne N ^b   Botelho, Françoise V ^b   Vieira, Leda Q ^b   Pich, Claus T ^a   Terenzi, Hernán ^a   Pereira Maia, Elene C ^b  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Cellular uptake; Cytotoxicity; Dicopper(II) complex; DNA binding; Nuclease activity

Indexed keywords

CARBOPLATIN; CISPLATIN; COPPER; COPPER HYDROLASE; DISTAMYCIN A; DNA; DOUBLE STRANDED DNA; HYDROLASE; PLASMID DNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CELL GROWTH; CELL STRAIN K 562; CELL VIABILITY; CHRONIC MYELOID LEUKEMIA; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DNA ADDUCT; DNA CLEAVAGE; DRUG DNA INTERACTION; DRUG STRUCTURE; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; HYDROLYSIS; IC 50; LUNG SMALL CELL CANCER; MACROPHAGE; MALE; NONHUMAN; PROTON TRANSPORT; SPECTROPHOTOMETRY; TUMOR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; COPPER; DISTAMYCINS; DNA ADDUCTS; DNA CLEAVAGE; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; K562 CELLS; KINETICS; MACROPHAGES, PERITONEAL; MALE; MICE; NEOPLASMS; ORGANOMETALLIC COMPOUNDS;

EID: 70349434736     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2009.05.008     Document Type: Article

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