An inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3

Parasites and Vectors

Volumn 7, Issue 1, 2014, Pages

  Efstathiou, Antonia ^a   Gaboriaud Kolar, Nicolas ^b   Smirlis, Despina ^a   Myrianthopoulos, Vassilios ^b   Vougogiannopoulou, Konstantina ^b   Alexandratos, Alexandros ^a   Kritsanida, Marina ^b   Mikros, Emmanuel ^b   Soteriadou, Ketty ^a   Skaltsounis, Alexios Leandros ^b  

^a HELLENIC PASTEUR INSTITUTE   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

Author keywords

Binding site solvation; Indirubins; Leishmania; LGSK 3; Szmap

Indexed keywords

ANTILEISHMANIAL AGENT; CYCLIN DEPENDENT KINASE 1; GLYCOGEN SYNTHASE KINASE 3; INDIRUBIN; INDIRUBIN DERIVATIVE; LEISHMANIAL CDC2 RELATED PROTEIN KINASE 3; LEISHMANIAL GLYCOGEN SYNTHASE KINASE 3; PIPERAZINE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG; ASI1 PROTEIN, S CEREVISIAE; CYCLIN DEPENDENT KINASE; INDOLE DERIVATIVE; MEMBRANE PROTEIN; MOLECULAR LIBRARY; SACCHAROMYCES CEREVISIAE PROTEIN;

ALGORITHM; AMASTIGOTE; ANIMAL CELL; ANTILEISHMANIAL ACTIVITY; ARTICLE; BINDING ASSAY; CELL CYCLE; CELL DEATH; CONTROLLED STUDY; DNA CONTENT; DRUG ACTIVITY; FLOW CYTOMETRY; LEISHMANIA; LEISHMANIA DONOVANI; MOUSE; NONHUMAN; PROMASTIGOTE; RESAZURIN ASSAY; SOLVATION; THERMODYNAMICS; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; MOLECULAR LIBRARY; PROTEIN CONFORMATION; SPECIES DIFFERENCE;

LEISHMANIA DONOVANI; MAMMALIA; MOLLUSCA;

ANIMALS; BINDING SITES; CDC2-CDC28 KINASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCOGEN SYNTHASE KINASE 3; INDOLES; LEISHMANIA; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; SACCHAROMYCES CEREVISIAE PROTEINS; SMALL MOLECULE LIBRARIES; SPECIES SPECIFICITY;

EID: 84902119400     PISSN: None     EISSN: 17563305     Source Type: Journal    
DOI: 10.1186/1756-3305-7-234     Document Type: Article

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