Alpha-lipoic acid protects against cisplatin-induced ototoxicity via the regulation of MAPKs and proinflammatory cytokines

Biochemical and Biophysical Research Communications

Volumn 449, Issue 2, 2014, Pages 183-189

  Kim, Jeongho ^a   Cho, Hyun Ju ^a   Sagong, Borum ^a   Kim, Se Jin ^b   Lee, Jae Tae ^c   So, Hong Seob ^b   Lee, In Kyu ^c   Kim, Un Kyung ^a   Lee, Kyu Yup ^c   Choo, Yon Sik ^a  

^a Kyungpook National University   (South Korea)

^b Wonkwang University School of Medicine   (South Korea)

^c Kyungpook National University School of Medicine   (South Korea)

Author keywords

Alpha lipoic acid; Cisplatin; Cochlear explant; MAPKs; Ototoxicity; Proinflammatory cytokines

Indexed keywords

CASPASE 3; CISPLATIN; I KAPPA B ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; SYNAPTOPHYSIN; THIOCTIC ACID;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CORTI ORGAN; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME REGULATION; EX VIVO STUDY; EXPLANT; HAIR CELL; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

RATTUS;

ALPHA-LIPOIC ACID; CISPLATIN; COCHLEAR EXPLANT; MAPKS; OTOTOXICITY; PROINFLAMMATORY CYTOKINES;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL LINE; CISPLATIN; CYTOKINES; GENE EXPRESSION; HAIR CELLS, AUDITORY; I-KAPPA B PROTEINS; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; INTERLEUKIN-6; MAP KINASE SIGNALING SYSTEM; MICE; ORGAN OF CORTI; RATS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; THIOCTIC ACID;

EID: 84902077510     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.04.118     Document Type: Article

References (37)

1. E.E. Trimmer, and J.M. Essigmann Cisplatin Essays Biochem. 34 1999 191 211 (Pubitemid 129638938)
2. L.P. Rybak, and T. Kelly Ototoxicity: bioprotective mechanisms Curr. Opin. Otolaryngol. Head Neck Surg. 11 2003 328 333 (Pubitemid 37176002)
3. D.L. Bodenner, P.C. Dedon, P.C. Keng, J.C. Katz, and R.F. Borch Selective protection against cis-diamminedichloroplatinum(II)-induced toxicity in kidney, gut, and bone marrow by diethyldithiocarbamate Cancer Res. 46 1986 2751 2755 (Pubitemid 16074275)
4. F.P. Hamers, J.H. Brakkee, E. Cavalletti, M. Tedeschi, L. Marmonti, G. Pezzoni, J.P. Neijt, and W.H. Gispen Reduced glutathione protects against cisplatin-induced neurotoxicity in rats Cancer Res. 53 1993 544 549 (Pubitemid 23059434)
5. L.P. Rybak, R. Ravi, and S.M. Somani Mechanism of protection by diethyldithiocarbamate against cisplatin ototoxicity: antioxidant system Fundam. Appl. Toxicol. 26 1995 293 300
6. M.J. McKeage Comparative adverse effect profiles of platinum drugs Drug Saf. 13 1995 228 244
7. P. Devarajan, M. Savoca, M.P. Castaneda, M.S. Park, N. Esteban-Cruciani, G. Kalinec, and F. Kalinec Cisplatin-induced apoptosis in auditory cells: role of death receptor and mitochondrial pathways Hear. Res. 174 2002 45 54 (Pubitemid 35305031)
8. W. Liu, H. Staecker, H. Stupak, B. Malgrange, P. Lefebvre, and T.R. Van De Water Caspase inhibitors prevent cisplatin-induced apoptosis of auditory sensory cells Neuroreport 9 1998 2609 2614 (Pubitemid 28387158)
9. E.R. Jamieson, and S.J. Lippard Structure, recognition, and processing of cisplatin-DNA adducts Chem. Rev. 99 1999 2467 2498
10. S. Sugiyama, M. Hayakawa, T. Kato, Y. Hanaki, K. Shimizu, and T. Ozawa Adverse effects of anti-tumor drug, cisplatin, on rat kidney mitochondria: disturbances in glutathione peroxidase activity Biochem. Biophys. Res. Commun. 159 1989 1121 1127 (Pubitemid 19101098)
11. H. Matsushima, K. Yonemura, K. Ohishi, and A. Hishida The role of oxygen free radicals in cisplatin-induced acute renal failure in rats J. Lab. Clin. Med. 131 1998 518 526 (Pubitemid 28278570)
12. K.I. Watanabe, A. Hess, W. Bloch, and O. Michel Nitric oxide synthase inhibitor suppresses the ototoxic side effect of cisplatin in guinea pigs Anticancer Drugs 11 2000 401 406 (Pubitemid 30459476)
13. G. Ramesh, and W.B. Reeves TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity J. Clin. Invest. 110 2002 835 842
14. G. Ramesh, and W.B. Reeves Salicylate reduces cisplatin nephrotoxicity by inhibition of tumor necrosis factor-alpha Kidney Int. 65 2004 490 499
15. H. So, H. Kim, J.H. Lee, C. Park, Y. Kim, E. Kim, J.K. Kim, K.J. Yun, K.M. Lee, H.Y. Lee, S.K. Moon, D.J. Lim, and R. Park Cisplatin cytotoxicity of auditory cells requires secretions of proinflammatory cytokines via activation of ERK and NF-kappaB J. Assoc. Res. Otolaryngol. 8 2007 338 355 (Pubitemid 47222431)
16. M. Previati, I. Lanzoni, L. Astolfi, F. Fagioli, G. Vecchiati, A. Pagnoni, A. Martini, and S. Capitani Cisplatin cytotoxicity in organ of Corti-derived immortalized cells J. Cell. Biochem. 101 2007 1185 1197 (Pubitemid 47253719)
17. N. Haramaki, D. Han, G.J. Handelman, H.J. Tritschler, and L. Packer Cytosolic and mitochondrial systems for NADH- and NADPH-dependent reduction of alpha-lipoic acid Free Radic. Biol. Med. 22 1997 535 542 (Pubitemid 27020128)
18. G.P. Biewenga, G.R. Haenen, and A. Bast The pharmacology of the antioxidant lipoic acid Gen. Pharmacol. 29 1997 315 331
19. L. Packer, E.H. Witt, and H.J. Tritschler Alpha-lipoic acid as a biological antioxidant Free Radic. Biol. Med. 19 1995 227 250
20. L. Packer, K. Kraemer, and G. Rimbach Molecular aspects of lipoic acid in the prevention of diabetes complications Nutrition 17 2001 888 895 (Pubitemid 33001657)
21. S. Alegre Vde, J.M. Barone, S.C. Yamasaki, L. Zambotti-Villela, and P.F. Silveira Lipoic acid effects on renal function, aminopeptidase activities and oxidative stress in Crotalus durissus terrificus envenomation in mice Toxicon 56 2010 402 410
22. K. Winiarska, D. Malinska, K. Szymanski, M. Dudziak, and J. Bryla Lipoic acid ameliorates oxidative stress and renal injury in alloxan diabetic rabbits Biochimie 90 2008 450 459
23. L.P. Rybak, K. Husain, C. Whitworth, and S.M. Somani Dose dependent protection by lipoic acid against cisplatin-induced ototoxicity in rats: antioxidant defense system Toxicol. Sci. 47 1999 195 202 (Pubitemid 29214827)
24. G.M. Kalinec, P. Webster, D.J. Lim, and F. Kalinec A cochlear cell line as an in vitro system for drug ototoxicity screening Audiol. Neurootol. 8 2003 177 189 (Pubitemid 36736926)
25. U. Wenzel, A. Nickel, and H. Daniel Alpha-lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2- generation Apoptosis 10 2005 359 368 (Pubitemid 40603489)
26. Y.C. Lin, Y.S. Lai, and T.C. Chou The protective effect of alpha-lipoic acid in lipopolysaccharide-induced acute lung injury is mediated by heme oxygenase-1 Evid. Based Complement Altern. Med. 2013 2013 590363
27. K.C. Campbell, R.P. Meech, L.P. Rybak, and L.F. Hughes The effect of d-methionine on cochlear oxidative state with and without cisplatin administration: mechanisms of otoprotection J. Am. Acad. Audiol. 14 2003 144 156
28. P. Giordano, G. Lorito, A. Ciorba, A. Martini, and S. Hatzopoulos Protection against cisplatin ototoxicity in a Sprague-Dawley rat animal model Acta Otorhinolaryngol. Ital. 26 2006 198 207
29. W.K. Low, L. Sun, M.G. Tan, A.W. Chua, and D.Y. Wang l-N-Acetylcysteine protects against radiation-induced apoptosis in a cochlear cell line Acta Otolaryngol. 128 2008 440 445 (Pubitemid 351450920)
30. S.J. Kim, H.J. Jeong, N.Y. Myung, M.C. Kim, J.H. Lee, H.S. So, R.K. Park, H.M. Kim, J.Y. Um, and S.H. Hong The protective mechanism of antioxidants in cadmium-induced ototoxicity in vitro and in vivo Environ. Health Perspect. 116 2008 854 862
31. D.T. Dickey, Y.J. Wu, L.L. Muldoon, and E.A. Neuwelt Protection against cisplatin-induced toxicities by N-acetylcysteine and sodium thiosulfate as assessed at the molecular, cellular, and in vivo levels J. Pharmacol. Exp. Ther. 314 2005 1052 1058 (Pubitemid 41205968)
32. B.J. Conlon, J.M. Aran, J.P. Erre, and D.W. Smith Attenuation of aminoglycoside-induced cochlear damage with the metabolic antioxidant alpha-lipoic acid Hear. Res. 128 1999 40 44 (Pubitemid 29083243)
33. B. Pouyatos, C. Gearhart, A. Nelson-Miller, S. Fulton, and L.D. Fechter Lipoic acid and 6-formylpterin reduce potentiation of noise-induced hearing loss by carbon monoxide: preliminary investigation J. Rehabil. Res. Dev. 45 2008 1053 1064
34. K. Husain, C. Whitworth, S.M. Somani, and L.P. Rybak Partial protection by lipoic acid against carboplantin-induced ototoxicity in rats Biomed. Environ. Sci. 18 2005 198 206 (Pubitemid 41127548)
35. S.A. Marsh, B.K. Pat, G.C. Gobe, and J.S. Coombes Evidence for a non-antioxidant, dose-dependent role of alpha-lipoic acid in caspase-3 and ERK2 activation in endothelial cells Apoptosis 10 2005 657 665 (Pubitemid 40896671)
36. J. Moungjaroen, U. Nimmannit, P.S. Callery, L. Wang, N. Azad, V. Lipipun, P. Chanvorachote, and Y. Rojanasakul Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation J. Pharmacol. Exp. Ther. 319 2006 1062 1069
37. J.J. Casciari, N.H. Riordan, T.L. Schmidt, X.L. Meng, J.A. Jackson, and H.D. Riordan Cytotoxicity of ascorbate, lipoic acid, and other antioxidants in hollow fibre in vitro tumours Br. J. Cancer 84 2001 1544 1550 (Pubitemid 32579348)