Partial protection by lipoic acid against carboplantin-induced ototoxicity in rats

Biomedical and Environmental Sciences

Volumn 18, Issue 3, 2005, Pages 198-206

  Husain, Kazim ^a   Whitworth, Craig ^a   Somani, Satu M ^a,b   Rybak, Leonard P ^a  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PONCE SCHOOL OF MEDICINE   (Puerto Rico)

Author keywords

Alpha lipoic acid; Antioxidants; Carboplatin; Ototoxicity; Rats

Indexed keywords

ANTIOXIDANT; CARBOPLATIN; CATALASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; MALONALDEHYDE; PROTECTIVE AGENT; SUPEROXIDE DISMUTASE; THIOCTIC ACID;

ANIMAL; ARTICLE; AUDITORY THRESHOLD; CHEMICALLY INDUCED DISORDER; COCHLEA; DRUG EFFECT; ENZYMOLOGY; EVOKED BRAIN STEM AUDITORY RESPONSE; LIPID PEROXIDATION; MALE; METABOLISM; PERCEPTION DEAFNESS; RAT; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; AUDITORY THRESHOLD; CARBOPLATIN; CATALASE; COCHLEA; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; HEARING LOSS, SENSORINEURAL; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; PROTECTIVE AGENTS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; THIOCTIC ACID;

RATTUS NORVEGICUS;

EID: 23744500504     PISSN: 08953988     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Steiner, H., Holtl, L., Wirtenberger, W., Berger, A. P., Bartsch, G., and Hobisch, A. (2002). Long term experience with carboplatin monotherapy for clinical stage I seminoma: a retrospective single center study. Urology 60, 324-328.
2. Ettinger, D. S. (1998). The role of carboplatin in the treatment of small-cell lung cancer. Oncology (Huntingt) 12, 36-43.
3. Cavaletti, G., Bogliun, G., Zincone, A., Marzorati, L., Melzi, P., Frattola, L., Marzola, M., Bonazzi, C., Cantu, M. G., Chiari, S., Galli, A., Bregni, M., and Gianni, M. (1998). Neuro and ototoxicity of high dose carboplatin treatment in poor prognosis ovarian cancer patients. Anticancer Res. 18, 3797-3802.
4. Bohm, S., Oriana, S., Spatti, G., DiRe, F., Breasciani, G., Pirovano, C., Grosso, I., Martini, C., Caraceni, A., Pilotti, S., and Zunini, F. (1999). Dose intensification of platinum compounds with glutathione protection as induction chemotherapy for advanced ovarian carcinoma. Oncology 57, 115-120.
5. Wandt, H., Birkmann, J., Denzel, T., Schafer, K., Schwab, G., Pilz, D., Egger, H., Both, A., and Gallmeir, W. M. (1999). Sequential cycles of high dose chemotherapy with dose escalation carboplatin with or without paclitaxel supported by G-CSF mobilized peripheral blood progenitor cells: a phase I/II study in advanced ovarian cancer. Bone Marrow Transplant 23, 763-770.
6. Simon, T., Hero, B., Dupuis, W., Selle, B., and Berthold, F. (2002). The incidence if hearing impairment after successful treatment of neuroblastoma. Klin. Padiatr. 214, 149-152.
7. Obermair, A., Speiser, P., Thoma, M., Kaider, A., Salzer, H., Dittrich, C., and Sevelda, R. (1998). Prediction of toxicity but not of clinical course by determining carboplatin exposure in patients with epithelial ovarian cancer treated with a combination of carboplatin and cisplatin. Int. J. Oncol. 13, 1023-1030.
8. Neuwelt, E. A., Brummet, R. E., Doolittle, N. D., Maldoon, L. L., Kroll, R. A., Pagel, M. A., Dojan, R., Church, V., Remsen, L. G., and Bubalo, J. S. (1998). First evidence of otoprotection against caboplatin-induced hearing loss with a two compartment system in patient with central nervous system malignancy using sodium thiosulfate. J. Pharmacol. Exp. Therap. 286, 77-84.
9. Husain, K., Scott, R. B., Whitworth, C., Somani, S. M., and Rybak, L. P. (2001a). Dose response of carboplatin-induced hearing loss in rats: antioxidant defense system. Hear. Res. 151, 71-78.
10. Hu, B. H., McFadden, S. L., Salvi, R. J., and Henderson, D. (1999). Intracochlear infusion of buthionine sulfoximine potentiates carboplatin ototoxicity in the chinchilla. Hear. Res. 128, 125-134.
11. Taudy, M, Syka, J, Popelar, J, and Ulehlova, L. (1992). Carboplatin and cisplatin ototoxicity in guinea pigs. Audiology 31, 293-299.
12. Husain, K., Whitworth, C., Somani, S. M., and Rybak, L. P. (2001b). Carboplatin-induced oxidative stress in rat cochlea. Hear. Res. 158, 14-22.
13. Rick, O., Beyer, J., Schwella, N., Schubart, H., Schleicher, J., and Sieger, W. (2001). Assessment of amifostine as protection from chemotherapy-induced toxicities after conventional-dose and high dose chemotherapy in patients with germ cell tumor. Ann. Oncol. 12, 1151-1155.
14. Maestroni, G. J., Togni, M., and Covacci, V. (1997). Norepinephrine protects mice from acute lethal doses of carboplatin. Exp. Hematol. 25, 491-494.
15. Sredni, B., Albeck, M., Tichler, T., Shani, A., Shapira J., Bruderman, I, catane, R., Kaufman, B., and Kalechman, Y. (1995). Bonemarrow sparing and prevention of alopecia by AS101 in non-small cell lung cancer patients treated with carboplatin and etoposide. J. Clin. Oncol. 13, 2342-2353.
16. Dible, S. E., Siddik, Z. H., Boxall, F. E., and Harrap, K. R. (1987). The effect of diethyldithiocarbamate on the haematological toxicity and antitumour activity of carboplatin. Eur. J. Cancer Clin. Oncol. 23, 813-818.
17. Packer, L., Witt, E. H., and Tritschler, H. J. (1995). Alpha-lipoic acid as a biological antioxident. Free Rad. Biol. Med. 19, 227-250.
18. Biewenga, G. P., Haenen, G. R. R., and Bast, A. (1997). The pharmacology of the antioxidant lipoic acid. Gen. Pharmacol. 29, 315-331.
19. Panigrahi, M., Sadguna, Y., Shirakumar, B. R., Kolluri, S. V. R., Roy, S., Packer, L. and Ravindranath, V. (1996). Alpha-lipoic acis protects against perfusion injury following cerebral ischemia in rats. Brain Res. 717, 184-188.
20. Rybak, L. P., Husain, K., Whitworth, C., and Somani, S. M. (1999). Dose dependent protection by lipoic acid against cisplatin-induced ototoxicity in rats: antioxidant defense system. Toxicol. Sci. 47, 195-202
21. Ravi, R., Somani, S. M., and Rybak, L. P. (1995). Mechanism of cisplatin ototoxicity: Antioxidant system. Pharmacol. Toxicol. 76, 386-394.
22. Rybak, L. P., Ravi, R., and Somani, S. M. (1995). Mechanism of protection by diethyldithiocarbamate against cisplatin ototoxicity: Antioxidant system. Fund. Appl. Toxicol. 26, 293-300.
23. Fariss, M. W. and Reed, D. J. (1987). High performance liquid chromatography of thiols and disulfides: dinitrophenol derivatives. Meth. Enzymol. 143, 101-109.
24. Misra, H. P. and Fridovich, I. (1972). The role of superoxide anion in the autooxidation of the epinephrine and a sample assay for superoxide dismutase. J. Biol. Chem. 247, 3170-3175.
25. Aebi, N. (1984). Catalase in vitro. Meth. Enzymol. 105, 121-126.
26. Flohe, L. and Gunzler, W. (1984). Assays of glutathione peroxidase. Meth. Enzymol. 105, 114-121.
27. Carlberg, I. and Mannervik, B. (1985). Glutathione Reductase. Meth. Enzymol. 113, 484-490.
28. Habig, W. H., Pabst, M. J., and Jakoby, W. B. (1974). Glutathione-s-transferases. The first step in mercapturic acid formation. J. Biol. Chem. 249, 7130-7139.
29. Ohkawa, H., Ohishi, N., and Yagi, K. (1979). Assay for lipid peroxides in animals and tissue by thiobarbituric acid reaction. Anal. Biochem. 95, 351-358.
30. Read, S. M. and Northcole, D. H. (1981). Minimization of variation in the response to different protein of the coomassie blue G dye-binding assay for protein. Anal. Biochem. 116, 53-64.
31. Younes, M. and Siegers, C. P. (1981). Mechanistic aspects of enhanced lipid peroxidation following glutathione depletion in vivo. Chem. Biol. Interact. 34, 257-266.
32. Smith, V. C. and Mitchell, J. R. (1989). Pharmacological Aspects of Glutathione in Drug Metabolism. Glutathione: Chemical, Biochemical, and Medical Aspects. (D. Dolphin, O. Avramovibc, and R. Poulson (Eds.), Wiley Press, New York..
33. Busse, E., Zimmer, G., Schopohl, B., and Kornhuber, B. (1992). Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo. Arznei. Forschung. 42, 829-831.
34. Ikeda, K., Sunose, H., and Takasaka, T. (1993). Effects of free radicals on the intracellular calcium concentration in the isolated outer hair cell of the guinea pig cochlea. Acta Otolaryngol. (Stockholm) 113, 137-141.
35. Clerici, W. J., DiMartino, D. L., and Prasad, M. R. (1995). Direct effects of reactive oxygen species on cochlear outer hair cell shape in vitro. Hear. Res. 84, 30-40.
36. DeWoskin, R. S. and Riviere, J. E. (1992). Cisplatin-induced loss of kidney copper and nephrotoxicity is ameliorated by single dose of diethyldithiocarbamate but not mesna. Toxicol. Appl. Pharmacol. 112, 182-189.
37. Pigeolet, E., Corbisier, P., Houbion, A., Lambert, D., Michiels, C., Raes, M., Zachary, M. D., and Ramacle, J. (1990). Glutathione peroxidase, superoxide dismutase and catalase inactivation by peroxides and oxygen derived free radicals. Mech. Ageing. Dev. 51, 283-297.
38. Marklund, S. L. (1992). Regulation of cytokines of extracellular superoxide dismutase and other superoxide dismutase isozymes in fibroblasts. J. Biol. Chem. 267, 6696-6701.
39. Sen, C. K. and Packer, L. (1996). Antioxidants and redox regulation of gene transcription. FASEB J. 10, 709-720.
40. Qazi, R., Chang, A. Y., Borch, R. F., Montine, T., Dedon, P., Loughner, J., and Bennett, M. (1988). Phase I clinical and pharmacokinetic study of diethyldithiocarbamate as a chemoprotector from toxic effects of cisplatin. J. Natl. Cancer Inst. 80, 1486-1488.