Mitochondrial thioredoxin reductase inhibition, selenium status, and Nrf-2 activation are determinant factors modulating the toxicity of mercury compounds

Free Radical Biology and Medicine

Volumn 73, Issue , 2014, Pages 95-105

  Branco, Vasco ^a   Godinho Santos, Ana ^a   Gonçalves, João ^a   Lu, Jun ^b   Holmgren, Arne ^b   Carvalho, Cristina ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Free radicals; Mercury; Methylmercury; Mitochondria; mRNA; Nrf 2; Selenium; Thioredoxin; Thioredoxin reductase

Indexed keywords

FREE RADICAL; MERCURY; MESSENGER RNA; SELENITE; SELENIUM; THIOREDOXIN; THIOREDOXIN REDUCTASE; TRANSCRIPTION FACTOR NRF2; MERCURY DERIVATIVE; NFE2L2 PROTEIN, HUMAN; THIOREDOXIN REDUCTASE 1; THIOREDOXIN REDUCTASE 2; TXNRD1 PROTEIN, HUMAN; TXNRD2 PROTEIN, HUMAN;

ARTICLE; CELL FRACTIONATION; CYTOSOL; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MERCURIALISM; MITOCHONDRION; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL SURVIVAL; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL SURVIVAL; ENZYME ACTIVATION; HEP G2 CELLS; HUMANS; MERCURY COMPOUNDS; MITOCHONDRIA; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; RNA, MESSENGER; SELENIUM; THIOREDOXIN REDUCTASE 1; THIOREDOXIN REDUCTASE 2; THIOREDOXINS;

EID: 84902013510     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.04.030     Document Type: Article

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