Thioredoxin Reductase Deficiency Potentiates Oxidative Stress, Mitochondrial Dysfunction and Cell Death in Dopaminergic Cells

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Lopert, Pamela ^a   Day, Brian J ^b   Patel, Manisha ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b DEPARTMENT OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; MESSENGER RNA; OXIDOPAMINE; PARAQUAT; PEROXIREDOXIN; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; THIOREDOXIN REDUCTASE; THIOREDOXIN REDUCTASE 2;

ANIMAL CELL; ARTICLE; BIOENERGY; CELL CULTURE; CELL DEATH; CELL IMMORTALIZATION; CELL ISOLATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOPAMINERGIC NERVE CELL; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME INHIBITION; ENZYME RELEASE; ENZYME SPECIFICITY; MESENCEPHALON; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PROTEIN FUNCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STEADY STATE;

ANIMALS; AURANOFIN; CELL DEATH; CELL LINE; CELL RESPIRATION; DOPAMINERGIC NEURONS; DRUG SYNERGISM; ENERGY METABOLISM; ENZYME INHIBITORS; GENE KNOCKDOWN TECHNIQUES; HYDROGEN PEROXIDE; LENTIVIRUS; MESENCEPHALON; MITOCHONDRIA; OXIDATIVE STRESS; OXIDOPAMINE; PARAQUAT; PEROXIREDOXINS; RATS; RNA, MESSENGER; RNA, SMALL INTERFERING; THIOREDOXIN REDUCTASE 2;

PARKINSONIA; RATTUS;

EID: 84870584588     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050683     Document Type: Article

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