Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase

Free Radical Biology and Medicine

Volumn 47, Issue 4, 2009, Pages 449-457

  Franco, Jeferson L ^a   Posser, Thaís ^a   Dunkley, Peter R ^b   Dickson, Phillip W ^b   Mattos, Jacó J ^a   Martins, Roberta ^a   Bainy, Afonso C D ^a   Marques, Maria R ^a   Dafre, Alcir L ^a   Farina, Marcelo ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b HUNTER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

Apoptosis; Free radicals; Glutathione peroxidase; Methylmercury; Mitochondria; SH SY5Y cells

Indexed keywords

CATALASE; DRINKING WATER; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HYDROPEROXIDE; METHYLMERCURY; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOMALIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN REGION; CELL VIABILITY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MODEL; DRUG TARGETING; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; INCUBATION TIME; INHIBITION KINETICS; LIPID PEROXIDATION; MALE; MERCURIALISM; MITOCHONDRION; MOUSE; NEUROBLASTOMA CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; BRAIN; DOWN-REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE PEROXIDASE; HUMANS; LIPID PEROXIDATION; MALE; METHYLMERCURY COMPOUNDS; MICE; MITOCHONDRIA; NEUROBLASTOMA; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES; THIOMALATES;

ANIMALIA; MUS;

EID: 67649998477     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.05.013     Document Type: Article

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