Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread

Neurobiology of Disease

Volumn 69, Issue , 2014, Pages 76-92

  Kovacs, Gabor G ^a   Breydo, Leonid ^b   Green, Ryan ^b   Kis, Viktor ^c   Puska, Gina ^c   Lorincz, Péter ^c   Perju Dumbrava, Laura ^a   Giera, Regina ^a   Pirker, Walter ^d   Lutz, Mirjam ^a   Lachmann, Ingolf ^e   Budka, Herbert ^a,h   Uversky, Vladimir N ^b,f,g   Molnár, Kinga ^c   László, Lajos ^c  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^d MEDICAL UNIVERSITY OF VIENNA   (Austria)

^e Roboscreen GmbH Leipzig   (Germany)

^f UNIVERSITY OF SOUTH FLORIDA   (United States)

^g INSTITUTE FOR BIOLOGICAL INSTRUMENTATION   (Russian Federation)

^h UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Endosome; Ependyma; Gap junction; Internalisation; Lysosome; Mitochondria; Nanotube; Prion like; Spreading; synuclein

Indexed keywords

4D6 ANTIBODY; ALPHA SYNUCLEIN; ANTIBODY; MONOMER; OLIGOMER; UNCLASSIFIED DRUG; SNCA PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; ASTROCYTE; ASTROCYTOSIS; BETA SHEET; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CRANIAL NERVE; DIFFUSE LEWY BODY DISEASE; EPENDYMA; FEMALE; GLIOSIS; HUMAN; HUMAN TISSUE; IMMUNOGOLD STAINING; IMMUNOHISTOCHEMISTRY; INTERNALIZATION; LEWY BODY; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MITOCHONDRION; NEUROPIL; PARKINSON DISEASE; PRIORITY JOURNAL; VERY ELDERLY; BRAIN; EXTRACELLULAR SPACE; GENETICS; IMMUNOLOGY; INTRACELLULAR SPACE; METABOLISM; MICROGLIA; NERVE CELL; PROTEIN SECONDARY STRUCTURE;

AGED; AGED, 80 AND OVER; ALPHA-SYNUCLEIN; ANTIBODIES; ASTROCYTES; BRAIN; EXTRACELLULAR SPACE; FEMALE; GLIOSIS; HUMANS; INTRACELLULAR SPACE; LEWY BODIES; LEWY BODY DISEASE; MALE; MICROGLIA; MIDDLE AGED; NEURONS; PARKINSON DISEASE; PROTEIN STRUCTURE, SECONDARY;

EID: 84901985544     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.05.020     Document Type: Article

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