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Volumn 12, Issue 7, 2011, Pages 1111-1125

Morphine sulfate and naltrexone hydrochloride extended release capsules for the management of chronic, moderate-to-severe pain, while reducing morphine-induced subjective effects upon tampering by crushing

Author keywords

Abuse; chronic pain; morphine; opioid

Indexed keywords

MORPHINE SULFATE; MORPHINE SULFATE PLUS NALTREXONE; PLACEBO;

EID: 79953893278     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.2011.571205     Document Type: Article
Times cited : (14)

References (67)
  • 1
    • 58949087497 scopus 로고    scopus 로고
    • Opioid treatment guidelines. Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain
    • Chou R, Fanciullo GJ, Fine PG, et al. Opioid treatment guidelines. Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. J Pain 2009;10:113-30
    • (2009) J Pain , vol.10 , pp. 113-30
    • Chou, R.1    Fanciullo, G.J.2    Fine, P.G.3
  • 2
    • 33745306870 scopus 로고    scopus 로고
    • Opioid therapy for chronic noncancer pain: Practice guidelines for initiation and maintenance of therapy
    • Coluzzi F, Pappagallo M. Opioid therapy for chronic noncancer pain: practice guidelines for initiation and maintenance of therapy. Minerva Anestesiol 2005;71:425-33 (Pubitemid 43932967)
    • (2005) Minerva Anestesiologica , vol.71 , Issue.7-8 , pp. 425-433
    • Coluzzi, F.1    Pappagallo, M.2
  • 3
    • 0029993578 scopus 로고    scopus 로고
    • Opioid analgesics: Comparative features and prescribing guidelines
    • Cherny NI. Opioid analgesics: comparative features and prescribing guidelines. Drugs 1996;51:713-37
    • (1996) Drugs , vol.51 , pp. 713-37
    • Cherny, N.I.1
  • 5
    • 77950825015 scopus 로고    scopus 로고
    • Practice guidelines for chronic pain management, an updated report by the American Society of Anesthesiologists Task Force on Chronic Pain Management and the American Society of Regional Anesthesia and Pain Medicine
    • American Society of Anesthesiologists Task Force and American Society of Regional Anesthesia and Pain Medicine
    • American Society of Anesthesiologists Task Force and American Society of Regional Anesthesia and Pain Medicine. Practice guidelines for chronic pain management, an updated report by the American Society of Anesthesiologists Task Force on Chronic Pain Management and the American Society of Regional Anesthesia and Pain Medicine. Anesthesiology 2010;112:810-33
    • (2010) Anesthesiology , vol.112 , pp. 810-33
  • 6
    • 48249112969 scopus 로고    scopus 로고
    • Opioids and the management of chronic severe pain in the elderly: Consensus statement of an international expert panel with focus on the six clinically most often used World Health Organization step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone)
    • Pergolizzi J, Boger RH, Budd K, et al. Opioids and the management of chronic severe pain in the elderly: consensus statement of an international expert panel with focus on the six clinically most often used World Health Organization step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone). World Inst Pain 2008;8:287-313
    • (2008) World Inst Pain , vol.8 , pp. 287-313
    • Pergolizzi, J.1    Boger, R.H.2    Budd, K.3
  • 7
  • 8
    • 79551523969 scopus 로고    scopus 로고
    • Defining clinical issues around tolerance, hyperalgesia, and addiction: A quantitative and qualitative outcome study of long-term opioid dosing in a chronic pain practice
    • Schneider JP, Kirsh KL. Defining clinical issues around tolerance, hyperalgesia, and addiction: a quantitative and qualitative outcome study of long-term opioid dosing in a chronic pain practice. J Opioid Manag 2010;6:385-95
    • (2010) J Opioid Manag , vol.6 , pp. 385-95
    • Schneider, J.P.1    Kirsh, K.L.2
  • 10
    • 33846423929 scopus 로고    scopus 로고
    • Opioid prescriptions soar: Increase in legitimate use as well as abuse
    • DOI 10.1001/jama.297.3.249
    • Kuehn BM. Opioid prescriptions soar: increase in legitimate use as well as abuse. JAMA 2007;297:249-51 (Pubitemid 46143290)
    • (2007) Journal of the American Medical Association , vol.297 , Issue.3 , pp. 249-251
    • Kuehn, B.M.1
  • 11
    • 34248388003 scopus 로고    scopus 로고
    • Scientists probe ways to curb opioid abuse without hindering pain treatment
    • DOI 10.1001/jama.297.18.1965
    • Kuehn BM. Scientists probe ways to curb opioid abuse without hindering pain treatment. JAMA 2007;297:1965-7 (Pubitemid 46740365)
    • (2007) Journal of the American Medical Association , vol.297 , Issue.18 , pp. 1965-1967
    • Kuehn, B.M.1
  • 13
    • 0012607259 scopus 로고    scopus 로고
    • Results from the 2009 National Survey on Drug Use and Health: Volume 1. Summary of National Findings (Office of Applied Studies, NSDUH Series H-38A, HHA Publication No. SMA 10-4586 Findings) Available from [Last accessed 8 October 2010]
    • Substance Abuse and Mental Health Services Administration. Results from the 2009 National Survey on Drug Use and Health: Volume 1. Summary of National Findings (Office of Applied Studies, NSDUH Series H-38A, HHA Publication No. SMA 10-4586 Findings), 2010. Available from: http://www.oas.samhsa.gov/NSDUH/ 2k9NSDUH/2k9ResultsP.pdf [Last accessed 8 October 2010]
    • (2010) Substance Abuse and Mental Health Services Administration
  • 15
    • 77953673796 scopus 로고    scopus 로고
    • Emergency department visits involving nonmedical use of selected prescription drugs-United States, 2004-2008
    • US Department of Health and Human Services
    • US Department of Health and Human Services. Emergency department visits involving nonmedical use of selected prescription drugs-United States, 2004-2008. Morb Mortal Wkly Rep 2010;59:705-14
    • (2010) Morb Mortal Wkly Rep , vol.59 , pp. 705-14
  • 16
    • 77953820533 scopus 로고    scopus 로고
    • Office of National Drug Control Policy Executive Office of the President Office of National Drug Control Policy, Executive Office of the President website. January 2008. Available from [Last accessed 4 May 2009]
    • Office of National Drug Control Policy Executive Office of the President. Prescription for danger: a report on the troubling trend of prescription and over-the-counter drug abuse among the nation's teens. Office of National Drug Control Policy, Executive Office of the President website. January 2008. Available from: http://www.theantidrug. com/pdfs/prescription-report.pdf [Last accessed 4 May 2009]
    • Prescription for Danger: A Report on the Troubling Trend of Prescription and Over-the-counter Drug Abuse among the Nation's Teens
  • 17
    • 33845934721 scopus 로고    scopus 로고
    • Motives, diversion and routes of administration associated with nonmedical use of prescription opioids
    • DOI 10.1016/j.addbeh.2006.05.022, PII S0306460306001705
    • McCabe SE, Cranford JA, Boyd CJ, Teter CJ. Motives, diversion and routes of administration associated with nonmedical use of prescription opioids. Addict Behav 2007;32:562-75 (Pubitemid 46038570)
    • (2007) Addictive Behaviors , vol.32 , Issue.3 , pp. 562-575
    • McCabe, S.E.1    Cranford, J.A.2    Boyd, C.J.3    Teter, C.J.4
  • 18
    • 67650730853 scopus 로고    scopus 로고
    • Issues in long-term opioid therapy: Unmet needs, risks, and solutions
    • Passik SD. Issues in long-term opioid therapy: unmet needs, risks, and solutions. Mayo Clin Proc 2009;84:593-601
    • (2009) Mayo Clin Proc , vol.84 , pp. 593-601
    • Passik, S.D.1
  • 19
    • 79955089902 scopus 로고    scopus 로고
    • US Food and Drug Administration Available from [Last accessed 14 February 2011]
    • US Food and Drug Administration. Outpatient prescription opioid utilization in the US, years 2000-2009. Available from: http://www.fda.gov/ downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/ AnestheticAndLifeSupportDrugsAdvisory Committee/UCM220950.pdf [Last accessed 14 February 2011]
    • Outpatient Prescription Opioid Utilization in the US Years 2000-2009
  • 20
    • 84856368153 scopus 로고    scopus 로고
    • RADARS system data indicate immediate release opioids responsible for higher proportion of misuse, abuse and diversion than extended release opioids
    • Available from [Last accessed 28 March 2011]
    • RADARS system data indicate immediate release opioids responsible for higher proportion of misuse, abuse and diversion than extended release opioids. RADARS Syst News 2009;4(2). Available from: http://www.radars.org/LinkClick. aspx?fileticket=PEUldFIeRps% 3D&tabid=1114 [Last accessed 28 March 2011]
    • (2009) RADARS Syst News , vol.4 , Issue.2
  • 21
    • 34547852667 scopus 로고    scopus 로고
    • Extended-release opioids for the management of chronic non-malignant pain
    • Sloan P, Babul N. Extended-release opioids for the management of chronic non-malignant pain. Expert Opin Drug Deliv 2006;3:489-97
    • (2006) Expert Opin Drug Deliv , vol.3 , pp. 489-97
    • Sloan, P.1    Babul, N.2
  • 22
    • 79953850003 scopus 로고    scopus 로고
    • US Department of Health and Human Services Testimony before Senate Judiciary Subcommittee on Crime and Drugs 12 March Available from [Last accessed 19 May 2010]
    • Paulozzi LJ. Trends in unintentional drug overdose deaths. US Department of Health and Human Services Testimony before Senate Judiciary Subcommittee on Crime and Drugs. 12 March 2008. Available from: http://www.hhs.gov/asl/testify/ 2008/03/t20080312b.html [Last accessed 19 May 2010]
    • (2008) Trends in Unintentional Drug Overdose Deaths
    • Paulozzi, L.J.1
  • 23
    • 33646026437 scopus 로고    scopus 로고
    • Development of opioid formulations with limited diversion and abuse potential
    • Fudala PJ, Johnson RE. Development of opioid formulations with limited diversion and abuse potential. Drug Alcohol Depend 2006;83(Suppl 1):S40-7
    • (2006) Drug Alcohol Depend , vol.83 , Issue.SUPPL. 1
    • Fudala, P.J.1    Johnson, R.E.2
  • 24
    • 67449100590 scopus 로고    scopus 로고
    • Opioid formulations in development designed to curtail abuse: Who is the target?
    • Webster LR, Bath B, Medve RA. Opioid formulations in development designed to curtail abuse: who is the target? Expert Opin Investig Drugs 2009;18:255-63
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 255-63
    • Webster, L.R.1    Bath, B.2    Medve, R.A.3
  • 25
    • 0037986601 scopus 로고    scopus 로고
    • Principles of initial experimental drug abuse liability assessment in humans
    • DOI 10.1016/S0376-8716(03)00098-X
    • Griffiths RR, Bigelow GE, Ator NA. Principles of initial experimental drug abuse liability assessment in humans. Drug Alcohol Depend 2003;70:S41-54 (Pubitemid 36577514)
    • (2003) Drug and Alcohol Dependence , vol.70 , Issue.3 SUPPL.
    • Griffiths, R.R.1    Bigelow, G.E.2    Ator, N.A.3
  • 26
    • 70449426117 scopus 로고    scopus 로고
    • Subjective effects and safety of whole and tampered morphine sulfate and naltrexone hydrochloride (ALO-01) extended-release capsules versus morphine solution and placebo in experienced non-dependent opioid users: A randomized, double-blind, placebo-controlled, crossover study
    • Stauffer J, Setnik B, Sokolowska M, et al. Subjective effects and safety of whole and tampered morphine sulfate and naltrexone hydrochloride (ALO-01) extended-release capsules versus morphine solution and placebo in experienced non-dependent opioid users: a randomized, double-blind, placebo-controlled, crossover study. Clin Drug Investig 2009;29:777-90
    • (2009) Clin Drug Investig , vol.29 , pp. 777-90
    • Stauffer, J.1    Setnik, B.2    Sokolowska, M.3
  • 27
    • 77954644065 scopus 로고    scopus 로고
    • Relative oral bioavailability of morphine and naltrexone derived from crushed morphine sulfate and naltrexone hydrochloride extended-release capsules versus intact product and versus naltrexone solution: A single-dose, randomized-sequence, open-label, three-way crossover trial in healthy volunteers
    • Johnson FK, Stark JG, Bieberdorf FA, Stauffer J. Relative oral bioavailability of morphine and naltrexone derived from crushed morphine sulfate and naltrexone hydrochloride extended-release capsules versus intact product and versus naltrexone solution: a single-dose, randomized-sequence, open-label, three-way crossover trial in healthy volunteers. Clin Ther 2010;32:1149-64
    • (2010) Clin Ther , vol.32 , pp. 1149-64
    • Johnson, F.K.1    Stark, J.G.2    Bieberdorf, F.A.3    Stauffer, J.4
  • 29
    • 78751642100 scopus 로고    scopus 로고
    • The relative bioavailability of morphine sulfate and naltrexone hydrochloride extended release capsules (EMBEDA) and an extended release morphine sulfate capsule formulation (KADIAN) in healthy adults under fasting conditions
    • Johnson FK, Ciric S, Boudriau S, et al. The relative bioavailability of morphine sulfate and naltrexone hydrochloride extended release capsules (EMBEDA) and an extended release morphine sulfate capsule formulation (KADIAN) in healthy adults under fasting conditions. Am J Ther 2011;18:2-8
    • (2011) Am J Ther , vol.18 , pp. 2-8
    • Johnson, F.K.1    Ciric, S.2    Boudriau, S.3
  • 30
    • 77949917186 scopus 로고    scopus 로고
    • ALO-01 (morphine sulfate and naltrexone hydrochloride) extended release capsules in the treatment of chronic pain of osteoarthritis of the hip or knee: Pharmacokinetics, efficacy, and safety
    • Katz N, Sun S, Johnson F, Stauffer J. ALO-01 (morphine sulfate and naltrexone hydrochloride) extended release capsules in the treatment of chronic pain of osteoarthritis of the hip or knee: pharmacokinetics, efficacy, and safety. J Pain 2010;11:303-11
    • (2010) J Pain , vol.11 , pp. 303-11
    • Katz, N.1    Sun, S.2    Johnson, F.3    Stauffer, J.4
  • 31
    • 78649320958 scopus 로고    scopus 로고
    • Food efffects on the pharmacokinetics of morphine sulfate and naltrexone hydrochloride extended release capsules
    • Johnson F, Ciric S, Boudriau S, et al. Food efffects on the pharmacokinetics of morphine sulfate and naltrexone hydrochloride extended release capsules. Adv Ther 2010;27:846-58
    • (2010) Adv Ther , vol.27 , pp. 846-58
    • Johnson, F.1    Ciric, S.2    Boudriau, S.3
  • 32
    • 0012607259 scopus 로고    scopus 로고
    • Drug Abuse Warning Network 2006: National Estimates of Drug-Related Emergency Department Visits (Office of Applied Studies, DAWN Series D-30, DHHS Publication No. SMA 08-4339) Available from [Last accessed 22 April 2009]
    • Substance Abuse and Mental Health Services Administration. Drug Abuse Warning Network, 2006: National Estimates of Drug-Related Emergency Department Visits (Office of Applied Studies, DAWN Series D-30, DHHS Publication No. SMA 08-4339), 2008. Available from: http://dawninfo.samhsa. gov/files/ED2006/ DAWN2k6ED.pdf [Last accessed 22 April 2009]
    • Substance Abuse and Mental Health Services Administration , pp. 2008
  • 33
    • 84860284724 scopus 로고    scopus 로고
    • Effects of alcohol on the pharmacokinetics of morphine sulfate and naltrexone hydrochloride extended release capsules
    • In press
    • Johnson FK, Ciric S, Boudriau S, et al. Effects of alcohol on the pharmacokinetics of morphine sulfate and naltrexone hydrochloride extended release capsules. J Clin Pharmacol; In press
    • J Clin Pharmacol
    • Johnson, F.K.1    Ciric, S.2    Boudriau, S.3
  • 34
    • 0020467490 scopus 로고
    • Assessment of the abuse liability of buspirone in recreational sedative users
    • Cole JO, Orzack MH, Beake B, et al. Assessment of the abuse liability of buspirone in recreational sedative users. J Clin Psychiatry 1982;43:69-74
    • (1982) J Clin Psychiatry , vol.43 , pp. 69-74
    • Cole, J.O.1    Orzack, M.H.2    Beake, B.3
  • 35
    • 0015026728 scopus 로고
    • Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man
    • Martin WR, Sloan JW, Sapira JD, Jasinski DR Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man. Clin Pharmacol Ther 1971;12:245-58
    • (1971) Clin Pharmacol Ther , vol.12 , pp. 245-58
    • Martin, W.R.1    Sloan, J.W.2    Sapira, J.D.3    Jasinski, D.R.4
  • 37
    • 77956640307 scopus 로고    scopus 로고
    • Morphine sulfate and naltrexone hydrochloride extended-release capsules in patients with chronic osteoarthritis pain
    • Katz N, Hale M, Morris D, Stauffer J. Morphine sulfate and naltrexone hydrochloride extended-release capsules in patients with chronic osteoarthritis pain. Postgrad Med 2010;122:112-28
    • (2010) Postgrad Med , vol.122 , pp. 112-28
    • Katz, N.1    Hale, M.2    Morris, D.3    Stauffer, J.4
  • 38
    • 33846671273 scopus 로고    scopus 로고
    • A 12-week, randomized, placebo-controlled trial assessing the safety and efficacy of oxymorphone extended release for opioid-naive patients with chronic low back pain
    • DOI 10.1185/030079906X162692
    • Katz N, Rauck R, Ahdieh H, et al. A 12-week, randomized, placebo-controlled trial assessing the safety and efficacy of oxymorphone extended release for opioid-naive patients with chronic low back pain. Curr Med Res Opin 2007;23:117-28 (Pubitemid 46191677)
    • (2007) Current Medical Research and Opinion , vol.23 , Issue.1 , pp. 117-128
    • Katz, N.1    Rauck, R.2    Ahdieh, H.3    Ma, T.4    Van Der Hoop, R.G.5    Kerwin, R.6    Podolsky, G.7
  • 39
    • 11144235004 scopus 로고    scopus 로고
    • Efficacy and safety of oxymorphone extended release in chronic low back pain: Results of a randomized, double-blind, placebo- and active-controlled phase III study
    • DOI 10.1016/j.jpain.2004.09.005, PII S1526590004009691
    • Hale ME, Dvergsten C, Gimbel J. Efficacy and safety of oxymorphone extended release in chronic low back pain: results of a randomized, double-blind, placebo-and active-controlled phase III study. J Pain 2005;6:21-8 (Pubitemid 40051998)
    • (2005) Journal of Pain , vol.6 , Issue.1 , pp. 21-28
    • Hale, M.E.1    Dvergsten, C.2    Gimbel, J.3
  • 40
    • 78349272369 scopus 로고    scopus 로고
    • Long-term safety and efficacy of morphine sulfate and naltrexone hydrochloride extended release capsules, a novel formulation containing morphine and sequestered naltrexone, in patients with chronic, moderate to severe pain
    • Webster LR, Brewer R, Wang C, et al. Long-term safety and efficacy of morphine sulfate and naltrexone hydrochloride extended release capsules, a novel formulation containing morphine and sequestered naltrexone, in patients with chronic, moderate to severe pain. J Pain Symptom Manage 2010;40:734-46
    • (2010) J Pain Symptom Manage , vol.40 , pp. 734-46
    • Webster, L.R.1    Brewer, R.2    Wang, C.3
  • 41
    • 65749098996 scopus 로고    scopus 로고
    • Long-term safety, tolerability, and efficacy of OROS hydromorphone in patients with chronic pain
    • Wallace M, Moulin DE, Rauck RL, et al. Long-term safety, tolerability, and efficacy of OROS hydromorphone in patients with chronic pain. J Opioid Manag 2009;5:97-105
    • (2009) J Opioid Manag , vol.5 , pp. 97-105
    • Wallace, M.1    Moulin, D.E.2    Rauck, R.L.3
  • 44
    • 33748036026 scopus 로고    scopus 로고
    • Randomized trial comparing polymer-coated extended-release morphine sulfate to controlled-release oxycodone HCl in moderate to severe nonmalignant pain
    • DOI 10.1185/030079906X115603
    • Nicholson B, Ross E, Sasaki J, Weil A. Randomized trial comparing polymer-coated extended-release morphine sulfate to controlled-release oxycodone HCl in moderate to severe nonmalignant pain. Curr Med Res Opin 2006;22:1503-14 (Pubitemid 44297429)
    • (2006) Current Medical Research and Opinion , vol.22 , Issue.8 , pp. 1503-1514
    • Nicholson, B.1    Ross, E.2    Sasaki, J.3    Weil, A.4
  • 46
    • 0032190657 scopus 로고    scopus 로고
    • Prolonged treatment with transdermal fentanyl in neuropathic pain
    • DOI 10.1016/S0885-3924(98)00070-0, PII S0885392498000700
    • Dellemijn PL, van Duijn H, Vanneste JA. Prolonged treatment with transdermal fentanyl in neuropathic pain. J Pain Symptom Manage 1998;16:220-9 (Pubitemid 28478235)
    • (1998) Journal of Pain and Symptom Management , vol.16 , Issue.4 , pp. 220-229
    • Dellemijn, P.L.I.1    Van Duijn, H.2    Vanneste, J.A.L.3
  • 47
    • 0036239777 scopus 로고    scopus 로고
    • Efficacy and safety of a once-daily morphine formulation in chronic, moderate-to-severe osteoarthritis pain: Results from a randomized, placebo-controlled, double-blind trial and an open-label extension trial
    • DOI 10.1016/S0885-3924(02)00383-4, PII S0885392402003834
    • Caldwell JR, Rapoport RJ, Davis JC, et al. Efficacy and safety of a once-daily morphine formulation in chronic, moderate-to-severe osteoarthritis pain: results from a randomized, placebo-controlled, double-blind trial and an open-label extension trial. J Pain Symptom Manage 2002;23:278-91 (Pubitemid 34462941)
    • (2002) Journal of Pain and Symptom Management , vol.23 , Issue.4 , pp. 278-291
    • Caldwell, J.R.1    Rapoport, R.J.2    Davis, J.C.3    Offenberg, H.L.4    Marker, H.W.5    Roth, S.H.6    Yuan, W.7    Eliot, L.8    Babul, N.9    Lynch, P.M.10
  • 48
    • 23244440994 scopus 로고    scopus 로고
    • Transdermal fentanyl versus sustained release oral morphine in strong-opioid naive patients with chronic low back pain
    • DOI 10.1097/01.brs.0000186860.23078.a8
    • Allan LG, Rucharz U, Simpson K, Slappendel R Transdermal fentanyl versus sustained release oral morphine in strong-opioid naive patients with chronic low back pain. Spine 2005;30:2484-90 (Pubitemid 41669082)
    • (2005) Spine , vol.30 , Issue.22 , pp. 2484-2490
    • Allan, L.1    Richarz, U.2    Simpson, K.3    Slappendel, R.4
  • 49
    • 79953897929 scopus 로고    scopus 로고
    • Evaluation of naltrexone concentrations following dosing with ALO-01 (morphine sulfate and naltrexone hydrochloride) extended release capsules for 1 year in patients with chronic pain
    • Reno, NV, USA, 20-25 June
    • Johnson F, Manning D, Wang C, Stauffer J. Evaluation of naltrexone concentrations following dosing with ALO-01 (morphine sulfate and naltrexone hydrochloride) extended release capsules for 1 year in patients with chronic pain. Poster presented at the 71st Annual Meeting of The College on Problems of Drug Dependence, Reno, NV, USA, 20-25 June 2009
    • (2009) Poster Presented at the 71st Annual Meeting of the College on Problems of Drug Dependence
    • Johnson, F.1    Manning, D.2    Wang, C.3    Stauffer, J.4
  • 50
    • 0021219060 scopus 로고
    • Bioequivalence, dose-proportionality, and pharmacokinetics of naltrexone after oral administration
    • Meyer MC, Straughn AB, Lo MW, et al. Bioequivalence, dose- proportionality, and pharmacokinetics of naltrexone after oral administration. J Clin Psychiatry 1984;45:15-19 (Pubitemid 14030105)
    • (1984) Journal of Clinical Psychiatry , vol.45 , Issue.9 , pp. 15-19
    • Meyer, M.C.1    Straughn, A.B.2    Lo, M.W.3
  • 52
    • 0041665111 scopus 로고    scopus 로고
    • The clinical opiate withdrawal scale (COWS)
    • Wesson DR, Ling W. The Clinical Opiate Withdrawal Scale (COWS). J Psychoactive Drugs 2003;35:253-9 (Pubitemid 36927370)
    • (2003) Journal of Psychoactive Drugs , vol.35 , Issue.2 , pp. 253-259
    • Wesson, D.R.1    Ling, W.2
  • 55
    • 77957313928 scopus 로고    scopus 로고
    • Acute opioid withdrawal precipitated by ingestion of crushed Embeda (morphine extended release with sequestered naltrexone): Case report and the focused review of the literature
    • Ruan X, Chen T, Gudin J, et al. Acute opioid withdrawal precipitated by ingestion of crushed Embeda (morphine extended release with sequestered naltrexone): case report and the focused review of the literature. J Opioid Manag 2010;6:300-3
    • (2010) J Opioid Manag , vol.6 , pp. 300-3
    • Ruan, X.1    Chen, T.2    Gudin, J.3
  • 56
    • 76549093421 scopus 로고    scopus 로고
    • Severe opioid withdrawal due to misuse of new combined morphine and naltrexone product (Embeda)
    • Jang DH, Robe JC, Hoffman RS. Severe opioid withdrawal due to misuse of new combined morphine and naltrexone product (Embeda). Ann Emerg Med 2010;55:303-4
    • (2010) Ann Emerg Med , vol.55 , pp. 303-4
    • Jang, D.H.1    Robe, J.C.2    Hoffman, R.S.3
  • 57
    • 17844396442 scopus 로고    scopus 로고
    • Universal precautions in pain medicine: A rational approach to the treatment of chronic pain
    • DOI 10.1111/j.1526-4637.2005.05031.x
    • Gourlay DL, Heit HA, Almahrezi A. Universal precautions in pain medicine: a rational approach to the treatment of chronic pain. Pain Med 2005;6:107-112 (Pubitemid 40590522)
    • (2005) Pain Medicine , vol.6 , Issue.2 , pp. 107-112
    • Gourlay, D.L.1    Heit, H.A.2    Almahrezi, A.3
  • 59
    • 44949084623 scopus 로고    scopus 로고
    • Abuse-deterrent opioid formulations: Are they a pipe dream?
    • Katz N. Abuse-deterrent opioid formulations: are they a pipe dream? Curr Rheumatol Rep 2008;10:11-18
    • (2008) Curr Rheumatol Rep , vol.10 , pp. 11-18
    • Katz, N.1
  • 60
    • 40349096417 scopus 로고    scopus 로고
    • Abuse deterrence focus of upcoming opioid formulations
    • 385
    • Lavine G. Abuse deterrence focus of upcoming opioid formulations. Am J Health Syst Pharm 2008;65:381,385
    • (2008) Am J Health Syst Pharm , vol.65 , pp. 381
    • Lavine, G.1
  • 62
    • 77954601357 scopus 로고    scopus 로고
    • Strategies to optimize pain management with opioids while minimizing risk of abuse
    • Brennan MJ, Stanos S. Strategies to optimize pain management with opioids while minimizing risk of abuse. PM R 2010;2:544-58
    • (2010) PM R , vol.2 , pp. 544-58
    • Brennan, M.J.1    Stanos, S.2
  • 63
    • 58149171960 scopus 로고    scopus 로고
    • Pain and addiction: Managing risk through comprehensive care
    • Gourlay DL, Heit HA. Pain and addiction: managing risk through comprehensive care. J Addict Dis 2008;27:23-30
    • (2008) J Addict Dis , vol.27 , pp. 23-30
    • Gourlay, D.L.1    Heit, H.A.2
  • 64
    • 0034785425 scopus 로고    scopus 로고
    • Tompkins C Balancing diversion control and medical necessity: The case of prescription drugs with abuse potential
    • Simoni-Wastila L, Tompkins C Balancing diversion control and medical necessity: the case of prescription drugs with abuse potential. Substance Abuse Misuse 2001;36:1275-96
    • (2001) Substance Abuse Misuse , vol.36 , pp. 1275-96
    • Simoni-Wastila, L.1
  • 65
    • 59649085663 scopus 로고    scopus 로고
    • National addictions vigilance intervention and prevention program (NAVIPPRO): A real-time, product-specific, public health surveillance system for monitoring prescription drug abuse
    • Butler SF, Budman SH, Licari A, et al. National addictions vigilance intervention and prevention program (NAVIPPRO): a real-time, product-specific, public health surveillance system for monitoring prescription drug abuse. Pharmacoepidemiol Drug Saf 2008;17:1142-54
    • (2008) Pharmacoepidemiol Drug Saf , vol.17 , pp. 1142-54
    • Butler, S.F.1    Budman, S.H.2    Licari, A.3
  • 66
    • 33846978076 scopus 로고    scopus 로고
    • The development of a comprehensive risk-management program for prescription opioid analgesics: Researched abuse, diversion and addiction-related surveillance (RADARS)
    • Cicero TJ, Dart RC, Inciardi JA, et al. The development of a comprehensive risk-management program for prescription opioid analgesics: researched abuse, diversion and addiction-related surveillance (RADARS). Pain Med 2007;8:157-70
    • (2007) Pain Med , vol.8 , pp. 157-70
    • Cicero, T.J.1    Dart, R.C.2    Inciardi, J.A.3
  • 67
    • 65549113312 scopus 로고    scopus 로고
    • Identification of drug and biological products deemed to have risk evaluation and mitigation strategies for purposes of the Food and Drug Administration Amendments Act of 2007 2008
    • Department of Health and Human Services Available from [Last accessed 21 February 2011]
    • Department of Health and Human Services. Identification of drug and biological products deemed to have risk evaluation and mitigation strategies for purposes of the Food and Drug Administration Amendments Act of 2007, 2008; Federal Register 73: 16313-4. Available from: http://www.fda. gov/OHRMS/DOCKETS/98fr/E8-6201. pdf [Last accessed 21 February 2011]
    • Federal Register , vol.73 , pp. 16313-4


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