Genetic and in vivo determinants of glucocorticoid sensitivity in relation to clinical outcome of childhood nephrotic syndrome

Kidney International

Volumn 85, Issue 6, 2014, Pages 1444-1453

  Teeninga, Nynke ^a   Kist Van Holthe, Joana E ^b   Van Den Akker, Erica L T ^c   Kersten, Marie C ^a   Boersma, Eric ^a   Krabbe, Hans G ^d   Knoers, Nine V A M ^e   Van Der Heijden, Albert J ^a   Koper, Jan W ^a   Nauta, Jeroen ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^d MEDISCH SPECTRUM TWENTE   (Netherlands)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

child; dexamethasone suppression test; frequent relapses; glucocorticoid receptor; nephrotic syndrome; prednisolone

Indexed keywords

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; PREDNISOLONE; DEXAMETHASONE; NR3C1 PROTEIN, HUMAN;

AGE; ALLELE; ARTICLE; CHILD; COHORT ANALYSIS; DNA POLYMORPHISM; DRUG SENSITIVITY; FEMALE; FOLLOW UP; GENDER; GENETICS; GENOTYPE; HAPLOTYPE; HETEROZYGOTE; HOMOZYGOSITY; HUMAN; IN VIVO STUDY; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY (TOPIC); NEPHROTIC SYNDROME; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); RELAPSE; AGONISTS; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED STUDY; DIAGNOSTIC USE; GENETIC POLYMORPHISM; MULTICENTER STUDY; NETHERLANDS; ONSET AGE; PHARMACOGENETICS; PHENOTYPE; PREDICTIVE VALUE; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; REMISSION; RISK FACTOR; TIME; TREATMENT OUTCOME;

AGE OF ONSET; CHILD; CHILD, PRESCHOOL; DEXAMETHASONE; FEMALE; GLUCOCORTICOIDS; HAPLOTYPES; HUMANS; MALE; NEPHROTIC SYNDROME; NETHERLANDS; PHARMACOGENETICS; PHENOTYPE; POLYMORPHISM, GENETIC; PREDICTIVE VALUE OF TESTS; PREDNISOLONE; PROSPECTIVE STUDIES; RECEPTORS, GLUCOCORTICOID; RECURRENCE; REMISSION INDUCTION; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME;

EID: 84901941254     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2013.531     Document Type: Article

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