Association of glucocorticoid receptor polymorphism A3669G in exon 9β with reduced central adiposity in women

Obesity

Volumn 14, Issue 5, 2006, Pages 759-764

  Syed, Akheel A ^a   Irving, Julie A E ^a   Redfern, Christopher P F ^a   Hall, Andrew G ^a   Unwin, Nigel C ^a,b   White, Martin ^b   Bhopal, Raj S ^c   Weaver, Jolanta U ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Cardiovascular disease; Europeans; Glucocorticoid receptor; Metabolic syndrome; South asians

Indexed keywords

CHOLESTEROL; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR BETA; HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AGED; ARTICLE; ASIAN; BLOOD; BLOOD PRESSURE; BODY MASS; CAUCASIAN; EXON; FEMALE; GENE FREQUENCY; GENETICS; GENOTYPE; HUMAN; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NUCLEOTIDE SEQUENCE; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; WAIST HIP RATIO;

ADIPOSITY; ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BASE SEQUENCE; BLOOD PRESSURE; BODY MASS INDEX; CHOLESTEROL; CHOLESTEROL, HDL; EUROPEAN CONTINENTAL ANCESTRY GROUP; EXONS; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, GLUCOCORTICOID; SEX FACTORS; WAIST-HIP RATIO;

EID: 33846885454     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2006.86     Document Type: Article

References (20)

1. Oakley RH, Sar M, Cidlowski JA. The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function. J Biol Chem. 1996;271:9550-9.
2. Bamberger CM, Bamberger AM, de Castro M, Chrousos GP. Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans. J Clin Invest. 1995;95:2435-41.
3. Oakley RH, Jewell CM, Yudt MR, Bofetiado DM, Cidlowski JA. The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action. J Biol Chem. 1999;274:27857-66.
4. Leung DY, Hamid Q, Vottero A, et al. Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta. J Exp Med. 1997;186:1567-74.
5. Sousa AR, Lane SJ, Cidlowski JA, Staynov DZ, Lee TH. Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor beta-isoform. J Allergy Clin Immunol. 2000;105:943-50.
6. DeRijk RH, Schaaf MJ, Turner G, et al. A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta-isoform mRNA is associated with rheumatoid arthritis. J Rheumatol. 2001;28:2383-8.
7. Schaaf MJ, Cidlowski JA. AUUUA motifs in the 3'UTR of human glucocorticoid receptor alpha and beta mRNA destabilize mRNA and decrease receptor protein expression. Steroids. 2002;67:627-36.
8. Da Silva JA, Larbre JP, Seed MP, et al. Sex differences in inflammation induced cartilage damage in rodents. The influence of sex steroids. J Rheumatol. 1994;21:330-7.
9. Da Silva JA, Peers SH, Perretti M, Willoughby DA. Sex steroids affect glucocorticoid response to chronic inflammation and to interleukin-1. J Endocrinol. 1993;136:389-97.
10. Farrar RS, Rodnick KJ. Sex-dependent effects of gonadal steroids and cortisol on cardiac contractility in rainbow trout. J Exp Biol. 2004;207:2083-93.
11. Deshaies Y, Dagnault A, Lalonde J, Richard D. Interaction of corticosterone and gonadal steroids on lipid deposition in the female rat. Am J Physiol. 1997;273:E355-62.
12. van Rossum EF, Voorhoeve PG, te Velde SJ, et al. The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults. J Clin Endocrinol Metab. 2004;89:4004-9.
13. Ward AM, Fall CH, Stein CE, et al. Cortisol and the metabolic syndrome in South Asians. Clin Endocrinol (Oxf). 2003;58:500-5.
14. Bhopal R, Unwin N, White M, et al. Heterogeneity of coronary heart disease risk factors in Indian, Pakistani, Bangladeshi, and European origin populations: cross sectional study. BMJ. 1999;319:215-20.
15. Fried SK, Russell CD, Grauso NL, Brolin RE. Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men. J Clin Invest. 1993;92:2191-8.
16. Brindley DN. Role of glucocorticoids and fatty acids in the impairment of lipid metabolism observed in the metabolic syndrome. Int J Obes Relat Metab Disord. 1995;19(Suppl 1):S69-75.
17. van Rossum EF, Koper JW, Huizenga NA, et al. A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels. Diabetes. 2002;51:3128-34.
18. Snehalatha C, Viswanathan V, Ramachandran A. Cutoff values for normal anthropometric variables in asian Indian adults. Diabetes Care. 2003;26:1380-4.
19. Dobson MG, Redfern CPF, Unwin N, Weaver JU. The N363S polymorphism of the glucocorticoid receptor: potential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus. J Clin Endocrinol Metab. 2001;86:2270-4.
20. Syed AA, Irving JA, Redfern CPF, et al. Low prevalence of the N363S polymorphism of the glucocorticoid receptor in South Asians living in the United Kingdom. J Clin Endocrinol Metab. 2004;89:232-5.