Brief report: Glucocorticoid receptor polymorphism affects transrepression but not transactivation

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 7, 2006, Pages 2800-2803

  Van Den Akker, Erica L T ^a   Russcher, Henk ^a   Van Rossum, Elisabeth F C ^a   Brinkmann, Albert O ^a   De Jong, Frank H ^a   Hokken, Anita ^a   Pols, Huibert A P ^a   Koper, Jan W ^a   Lamberts, Steven W J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CHOLESTEROL; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; HIGH DENSITY LIPOPROTEIN; HYDROCORTISONE; INTERLEUKIN 2; LEUCINE ZIPPER PROTEIN; DIAGNOSTIC AGENT; GLUCOCORTICOID;

ADULT; AGED; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CHEMICAL ANALYSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DNA POLYMORPHISM; DOWN REGULATION; EX VIVO STUDY; FEMALE; GENOTYPE; HAPLOTYPE; HUMAN; INSULIN SENSITIVITY; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSACTIVATION; WAIST HIP RATIO; AGING; BLOOD; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC POLYMORPHISM; GENETICS; HETEROZYGOTE; INSULIN RESISTANCE;

AGED; AGING; BODY MASS INDEX; C-REACTIVE PROTEIN; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DEXAMETHASONE; DOWN-REGULATION; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENOTYPE; GLUCOCORTICOIDS; HETEROZYGOTE; HUMANS; HYDROCORTISONE; INSULIN RESISTANCE; INTERLEUKIN-2; LEUCINE ZIPPERS; MALE; POLYMORPHISM, GENETIC; RECEPTORS, GLUCOCORTICOID; TRANS-ACTIVATION (GENETICS); WAIST-HIP RATIO;

EID: 33745802580     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2005-2119     Document Type: Article

References (22)

1. Kellendonk C, Tronche F, Reichardt HM, Schutz G 1999 Mutagenesis of the glucocorticoid receptor in mice. J Steroid Biochem Mol Biol 69:253-259
2. Buttgereit F, Burmester GR, Lipworth BJ 2005 Optimised glucocorticoid therapy: the sharpening of an old spear. Lancet 365:801-803
3. Huizenga NA, Koper JW, de Lange P, Pols HA, Stolk RP, Grobbee DE, de Jong FH, Lamberts SW 1998 Interperson variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo-pituitary-adrenal axis to a low dose of dexamethasone in elderly individuals. J Clin Endocrinol Metab 83:47-54
4. van Rossum EF, Lamberts SW 2004 Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition. Recent Prog Horm Res 59:333-357
5. Russcher H, van Rossum EF, de Jong FH, Brinkmann AO, Lamberts SW, Koper JW 2005 Increased expression of the glucocorticoid receptor-A translational isoform as a result of the ER22/23EK polymorphism. Mol Endocrinol 19:1687-1696
6. van Rossum EF, Koper JW, Huizenga NA, Uitterlinden AG, Janssen JA, Brinkmann AO, Grobbee DE, de Jong FH, van Duyn CM, Pols HA, Lamberts SW 2002 A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels. Diabetes 51:3128-3134
7. Stevens A, Ray DW, Zeggini E, John S, Richards HL, Griffiths CE, Donn R 2004 Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor haplotype. J Clin Endocrinol Metab 89:892-897
8. Schaaf MJ, Cidlowski JA 2002 AUUUA motifs in the 3′UTR of human glucocorticoid receptor α and β mRNA destabilize mRNA and decrease receptor protein expression. Steroids 67:627-636
9. Oakley RH, Sar M, Cidlowski JA 1996 The human glucocorticoid receptor β isoform. Expression, biochemical properties, and putative function. J Biol Chem 271:9550-9559
10. van den Akker EL, Nouwen JL, Melles DC, van Rossum EF, Koper JW, Uitterlinden AG, Hofman A, Verbrugh HA, Pols HA, Lamberts SW, van Belkum A 2006 Staphylococcal aureus nasal carriage is associated with glucocorticoid receptor gene polymorphisms. J Infect Dis, in press
11. Derijk RH, Schaaf MJ, Turner G, Datson NA, Vreugdenhil E, Cidlowski J, de Kloet ER, Emery P, Sternberg EM, Detera-Wadleigh SD 2001 A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor β-isoform mRNA is associated with rheumatoid arthritis. J Rheumatol 28:2383-2388
12. Hofman A, Grobbee DE, de Jong PT, van den Ouweland FA 1991 Determinants of disease and disability in the elderly: the Rotterdam Elderly Study. Eur J Epidemiol 7:403-422
13. van Rossum EF, Koper JW, van den Beld AW, Uitterlinden AG, Arp P, Ester W, Janssen JA, Brinkmann AO, de Jong FH, Grobbee DE, Pols HA, Lamberts SW 2003 Identification of the BclI polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index. Clin Endocrinol (Oxf) 59:585-592
14. Huizenga NA, Koper JW, De Lange P, Pols HA, Stolk RP, Burger H, Grobbee DE, Brinkmann AO, De Jong FH, Lamberts SW 1998 A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo. J Clin Endocrinol Metab 83:144-151
15. Stephens M, Smith NJ, Donnelly P 2001 A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68:978-989
16. Russcher H, Smit P, van den Akker EL, van Rossum EF, Brinkmann AO, de Jong FH, Lamberts SW, Koper JW 2005 Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression. J Clin Endocrinol Metab 90:5804-5810
17. Livak KJ, Schmittgen TD 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2[-ΔΔC(T)] method. Methods 25:402-408
18. Reichardt HM, Tronche F, Bauer A, Schutz G 2000 Molecular genetic analysis of glucocorticoid signaling using the Cre/loxP system. Biol Chem 381:961-964
19. Brogan IJ, Murray IA, Cerillo G, Needham M, White A, Davis JR 1999 Interaction of glucocorticoid receptor isoforms with transcription factors AP-1 and NF-κB: lack of effect of glucocorticoid receptor β. Mol Cell Endocrinol 157:95-104
20. Gougat C, Jaffuel D, Gagliardo R, Henriquet C, Bousquet J, Demoly P, Mathieu M 2002 Overexpression of the human glucocorticoid receptor α and β isoforms inhibits AP-1 and NF-κB activities hormone independently. J Mol Med 80:309-318
21. Strickland I, Kisich K, Hauk PJ, Vottero A, Chrousos GP, Klemm DJ, Leung DY 2001 High constitutive glucocorticoid receptor β in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids. J Exp Med 193:585-593
22. Pujols L, Mullol J, Roca-Ferrer J, Torrego A, Xaubet A, Cidlowski JA, Picado C 2002 Expression of glucocorticoid receptor α- and β-isoforms in human cells and tissues. Am J Physiol Cell Physiol 283:C1324-C1331