The clinical course of steroid-sensitive childhood nephrotic syndrome is associated with a functional IL12B promoter polymorphism

Nephrology Dialysis Transplantation

Volumn 23, Issue 12, 2008, Pages 3841-3844

  Müller Berghaus, Jan ^a,b   Kemper, Markus J ^c   Hoppe, Bernd ^d   Querfeld, Uwe ^e   Müller Wiefel, Dirk E ^c   Morahan, Grant ^f   Schadendorf, Dirk ^a   Tenbrock, Klaus ^g,h  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b PAUL EHRLICH INSTITUT   (Germany)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^d UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^f UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^g RWTH AACHEN UNIVERSITY   (Germany)

^h UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Child; Interleukin 12; Nephrotic syndrome; Th1; Th2

Indexed keywords

INTERLEUKIN 12; PREDNISONE; STEROID;

ADOLESCENT; ARTICLE; CORRELATION ANALYSIS; DENDRITIC CELL; DISEASE COURSE; FEMALE; GENE; GENETIC POLYMORPHISM; GENOTYPE; GLOMERULOPATHY; HUMAN; IL12B GENE; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALE; NEPHROTIC SYNDROME; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; SCHOOL CHILD; STEROID SENSITIVE NEPHROTIC SYNDROME; TH1 CELL; TH2 CELL;

ADOLESCENT; ADRENAL CORTEX HORMONES; ALLELES; CHILD; FEMALE; GENOTYPE; HUMANS; INTERLEUKIN-12 SUBUNIT P40; MALE; NEPHROTIC SYNDROME; POLYMORPHISM, GENETIC; PROGNOSIS; PROMOTER REGIONS, GENETIC; TH2 CELLS;

EID: 56749179523     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfn395     Document Type: Article

References (20)

1. Kemper MJ, Kuwertz-Broeking E, Bulla M et al. Recurrence of severe steroid dependency in cyclosporin A-treated childhood idiopathic nephrotic syndrome. Nephrol Dial Transplant 2004; 19: 1136-1141
2. Kemper MJ, Altrogge H, Ludwig K et al. Unfavorable response to cyclophosphamide in steroid-dependent nephrotic syndrome. Pediatr Nephrol 2000; 14: 772-775
3. Neuhaus TJ, Wadhwa M, Callard R et al. Increased IL-2, IL-4 and interferon-gamma (IFN-gamma) in steroid-sensitive nephrotic syndrome. Clin Exp Immunol 1995; 100: 475-479
4. Kimata H, Fujimoto M, Furusho K. Involvement of interleukin (IL)-13, but not IL-4, in spontaneous IgE and IgG4 production in nephrotic syndrome. Eur J Immunol 1995; 25: 1497-1501
5. Stachowski J, Barth C, Michalkiewicz J et al. Th1/Th2 balance and CD45-positive T cell subsets in primary nephrotic syndrome. Pediatr Nephrol 2000; 14: 779-785
6. Cheung W, Wei CL, Seah CC et al. Atopy, serumIgE, and interleukin-13 in steroid-responsive nephrotic syndrome. Pediatr Nephrol 2004; 19: 627-632
7. Arkwright PD, Clark G. Infantile nephrotic syndrome and atopy. Pediatr Nephrol 1996; 10: 509-510
8. Scharer K, Wahn U, Muller-Wiefel DE et al. Steroid-responsive nephrotic syndrome and allergy. Arch Dis Child 1982; 57: 401-402
9. Lin CY, Lee BH, Lin CC et al. A study of the relationship between childhood nephrotic syndrome and allergic diseases. Chest 1990; 97: 1408-1411
10. Lin CY, Chien JW. Increased interleukin-12 release from peripheral blood mononuclear cells in nephrotic phase of minimal change nephrotic syndrome. Acta Paediatr Taiwan 2004; 45: 77-80
11. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003; 3: 133-146
12. Morahan G, Huang D, Wu M et al. Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children. Lancet 2002; 360: 455-459
13. Morahan G, Boutlis CS, Huang D et al. A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production. Genes Immun 2002; 3: 414-418
14. Muller-Berghaus J, Kern K, Paschen A et al. Deficient IL-12p70 secretion by dendritic cells based on IL12B promoter genotype. Genes Immun 2004; 5: 431-434
15. Short versus standard prednisone therapy for initial treatment of idiopathic nephrotic syndrome in children. Arbeitsgemeinschaft fur Padiatrische Nephrologie. Lancet 1988; 1: 380-383
16. Primary nephrotic syndrome in children: clinical significance of histopathologic variants of minimal change and of diffuse mesangial hypercellularity. A Report of the International Study of Kidney Disease in Children. Kidney Int 1981; 20: 765-771
17. Brodehl J. The treatment of minimal change nephrotic syndrome: lessons learned from multicentre co-operative studies. Eur J Pediatr 1991; 150: 380-387
18. Tenbrock K, Schubert A, Stapenhorst L et al. Type I IgE receptor, interleukin 4 receptor and interleukin 13 polymorphisms in children with nephrotic syndrome. Clin Sci (Lond) 2002; 102: 507-512
19. Effect of cytotoxic drugs in frequently relapsing nephrotic syndrome with and without steroid dependence. N Engl J Med 1982; 306: 451-454
20. Florido JF, Diaz Pena JM, Belchi J et al. Nephrotic syndrome and respiratory allergy in childhood. J Investig Allergol Clin Immunol 1992; 2: 136-140