Polymorphisms in glucocorticoid receptor gene and the outcome of childhood acute lymphoblastic leukemia (ALL)

Leukemia Research

Volumn 34, Issue 4, 2010, Pages 492-497

  Labuda, Malgorzata ^a   Gahier, Annabel ^a   Gagné, Vincent ^a   Moghrabi, Albert ^a,b   Sinnett, Daniel ^a,b   Krajinovic, Maja ^a,b,c  

^a Centre de Cancerologie Charles Bruneau   (Canada)

^b UNIVERSITY OF MONTREAL   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Acute lymphoblastic leukemia; Childhood; Glucocorticoid receptor; Glucocorticoids; Pharmacogenetics; Polymorphism; Treatment

Indexed keywords

GLUCOCORTICOID RECEPTOR; ISOPROTEIN; MESSENGER RNA;

ACUTE LYMPHOBLASTIC LEUKEMIA; ALLELE; ARTICLE; CHILD; CHILDHOOD CANCER; CONTROLLED STUDY; EVENT FREE SURVIVAL; EXON; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; HAPLOTYPE; HETEROZYGOTE; HUMAN; INTRON; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE ANALYSIS; RNA ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

CELL LINE, TUMOR; CHILD; CHILD, PRESCHOOL; FEMALE; GENE FREQUENCY; HUMANS; INFANT; LINKAGE (GENETICS); MALE; OUTCOME ASSESSMENT (HEALTH CARE); POLYMORPHISM, SINGLE NUCLEOTIDE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS; PROTEIN ISOFORMS; RECEPTORS, GLUCOCORTICOID; SURVIVAL ANALYSIS;

EID: 76749097560     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2009.08.007     Document Type: Article

References (33)

1. Pui C.H., Relling M.V., and Downing J.R. Acute lymphoblastic leukemia. N Engl J Med 350 (2004) 1535-1548
2. Kofler R., Schmidt S., Kofler A., and Ausserlechner M.J. Resistance to glucocorticoid-induced apoptosis in lymphoblastic leukemia. J Endocrinol 178 (2003) 19-27
3. Frankfurt O., and Rosen S.T. Mechanisms of glucocorticoid-induced apoptosis in hematologic malignancies: updates. Curr Opin Oncol 16 (2004) 553-563
4. Watt G.C., Harrap S.B., Foy C.J., Holton D.W., Edwards H.V., Davidson H.R., et al. Abnormalities of glucocorticoid metabolism and the renin-angiotensin system: a four-corners approach to the identification of genetic determinants of blood pressure. J Hypertens 10 (1992) 473-482
5. Derijk R.H., van Leeuwen N., Klok M.D., and Zitman F.G. Corticosteroid receptor-gene variants: modulators of the stress-response and implications for mental health. Eur J Pharmacol 585 (2008) 492-501
6. van Rossum E.F., Koper J.W., van den Beld A.W., Uitterlinden A.G., Arp P., Ester W., et al. Identification of the BclI polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index. Clin Endocrinol (Oxf) 59 (2003) 585-592
7. van Rossum E.F., Binder E.B., Majer M., Koper J.W., Ising M., Modell S., et al. Polymorphisms of the glucocorticoid receptor gene and major depression. Biol Psychiatry 59 (2006) 681-688
8. Kumsta R., Moser D., Streit F., Koper J.W., Meyer J., and Wust S. Characterization of a glucocorticoid receptor gene (GR, NR3C1) promoter polymorphism reveals functionality and extends a haplotype with putative clinical relevance. Am J Med Genet B Neuropsychiatr Genet 150B (2009) 476-482
9. Fleury I., Primeau M., Doreau A., Costea I., Moghrabi A., Sinnett D., et al. Polymorphisms in genes involved in the corticosteroid response and the outcome of childhood acute lymphoblastic leukemia. Am J Pharmacogenomics 4 (2004) 331-341
10. Rosmond R., Chagnon Y.C., Chagnon M., Perusse L., Bouchard C., and Bjorntorp P. A polymorphism of the 5′-flanking region of the glucocorticoid receptor gene locus is associated with basal cortisol secretion in men. Metabolism 49 (2000) 1197-1199
11. Derijk R.H., Schaaf M.J., Turner G., Datson N.A., Vreugdenhil E., Cidlowski J., et al. A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta-isoform mRNA is associated with rheumatoid arthritis. J Rheumatol 28 (2001) 2383-2388
12. Oakley R.H., Jewell C.M., Yudt M.R., Bofetiado D.M., and Cidlowski J.A. The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action. J Biol Chem 274 (1999) 27857-27866
13. Moghrabi A., Levy D.E., Asselin B., Barr R., Clavell L., Hurwitz C., et al. Results of the Dana-Farber Cancer Institute ALL Consortium Protocol 95-01 for children with acute lymphoblastic leukemia. Blood 109 (2007) 896-904
14. Silverman L.B., Gelber R.D., Dalton V.K., Asselin B.L., Barr R.D., Clavell L.A., et al. Improved outcome for children with acute lymphoblastic leukemia: results of Dana-Farber Consortium Protocol 91-01. Blood 97 (2001) 1211-1218
15. Bourgeois S., and Labuda D. Dynamic allele-specific oligonucleotide hybridization on solid support. Anal Biochem 324 (2004) 309-311
16. Stephens M., and Donnelly P. A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 73 (2003) 1162-1169
17. Stephens M., Smith N.J., and Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68 (2001) 978-989
18. Dulucq S., St-Onge G., Gagne V., Ansari M., Sinnett D., Labuda D., et al. DNA variants in the dihydrofolate reductase gene and outcome in childhood ALL. Blood 111 (2008) 3692-3700
19. Levy A.S., Sather H.N., Steinherz P.G., Sowers R., La M., Moscow J.A., et al. Reduced folate carrier and dihydrofolate reductase expression in acute lymphocytic leukemia may predict outcome: a Children's Cancer Group Study. J Pediatr Hematol Oncol 25 (2003) 688-695
20. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (2001) 402-408
21. Krajinovic M., Costea I., Primeau M., Dulucq S., and Moghrabi A. Combining several polymorphisms of thymidylate synthase gene for pharmacogenetic analysis. Pharmacogenomics J 5 (2005) 374-380
22. Kumsta R., Entringer S., Koper J.W., van Rossum E.F., Hellhammer D.H., and Wust S. Glucocorticoid receptor gene polymorphisms and glucocorticoid sensitivity of subdermal blood vessels and leukocytes. Biol Psychol 79 (2008) 179-184
23. Stevens A., Ray D.W., Zeggini E., John S., Richards H.L., Griffiths C.E., et al. Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor haplotype. J Clin Endocrinol Metab 89 (2004) 892-897
24. Brouwer J.P., Appelhof B.C., van Rossum E.F., Koper J.W., Fliers E., Huyser J., et al. Prediction of treatment response by HPA-axis and glucocorticoid receptor polymorphisms in major depression. Psychoneuroendocrinology 31 (2006) 1154-1163
25. Panarelli M., Holloway C.D., Fraser R., Connell J.M., Ingram M.C., Anderson N.H., et al. Glucocorticoid receptor polymorphism, skin vasoconstriction, and other metabolic intermediate phenotypes in normal human subjects. J Clin Endocrinol Metab 83 (1998) 1846-1852
26. Tissing W.J., Meijerink J.P., den Boer M.L., Brinkhof B., van Rossum E.F., van Wering E.R., et al. Genetic variations in the glucocorticoid receptor gene are not related to glucocorticoid resistance in childhood acute lymphoblastic leukemia. Clin Cancer Res 11 (2005) 6050-6056
27. Kumsta R., Entringer S., Koper J.W., van Rossum E.F., Hellhammer D.H., and Wust S. Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress. Biol Psychiatry 62 (2007) 863-869
28. Robaey P., Krajinovic M., Marcoux S., and Moghrabi A. Pharmacogenetics of the neurodevelopmental impact of anticancer chemotherapy. Dev Disabil Res Rev 14 (2008) 211-220
29. Tissing W.J., Lauten M., Meijerink J.P., den Boer M.L., Koper J.W., Sonneveld P., et al. Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia. Haematologica 90 (2005) 1279-1281
30. Haarman E.G., Kaspers G.J., Pieters R., Rottier M.M., and Veerman A.J. Glucocorticoid receptor alpha, beta and gamma expression vs. in vitro glucocorticod resistance in childhood leukemia. Leukemia 18 (2004) 530-537
31. Beger C., Gerdes K., Lauten M., Tissing W.J., Fernandez-Munoz I., Schrappe M., et al. Expression and structural analysis of glucocorticoid receptor isoform gamma in human leukaemia cells using an isoform-specific real-time polymerase chain reaction approach. Br J Haematol 122 (2003) 245-252
32. Lauten M., Fernandez-Munoz I., Gerdes K., von Neuhoff N., Welte K., Schlegelberger B., et al. Kinetics of the in vivo expression of glucocorticoid receptor splice variants during prednisone treatment in childhood acute lymphoblastic leukaemia. Pediatr Blood Cancer 52 (2009) 459-463
33. Stevens A., Donn R., and Ray D. Regulation of glucocorticoid receptor gamma (GRgamma) by glucocorticoid receptor haplotype and glucocorticoid. Clin Endocrinol (Oxf) 61 (2004) 327-331