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Volumn 22, Issue 13, 2014, Pages 3393-3404
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Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo
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Author keywords
Apigenin; Apigenin analogues; Chronic pancreatitis; Fibrosis; Pancreatic stellate cells; Therapy
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Indexed keywords
1 [2 [4 (5,7 DIMETHOXY 4 OXO 4H CHROMEN 2 YL)PHENOXY]ETHYL]PYRROLIDIN 2 ONE;
1 [2 [4 (5,7 DIMETHOXY 4 OXO 4H CHROMEN 2 YL)PHENOXY]ETHYL]PYRROLIDINE 2 CARBOXYLIC ACID METHYL ESTER;
2 (4 BROMOPHENYL) 5,7 DIMETHOXYCHROMEN 4 ONE;
2 (4 HYDROXYPHENYL) 5,7 DIMETHOXYCHROMEN 4 ONE;
2 (4 [6 FLUOROPYRIDIN 3 YL)PHENYL] 5,7 DIMETHOXYCHROMEN 4 ONE;
2 [4 (2 AMINOETHOXY)PHENYL] 5,7 DIMETHOXYCHROMEN 4 ONE;
2 [4 (2 BROMOETHOXY)PHENYL] 5,7 DIMETHOXYCHROMEN 4 ONE;
2 [4 (2 DIETHYLAMINOETHOXY)PHENYL] 5,7 DIMETHOXYCHROMEN 4 ONE;
2 [4 (2 DIMETHYLAMINOETHOXY)PHENYL] 5,7 DIMETHOXYCHROMEN 4 ONE;
2 [4 (2 DIMETHYLAMINOETHYLAMINO)PHENYL] 5,7 DIMETHOXYCHROMEN 4 ONE;
2 [4 (2 FLUOROETHOXY)PHENYL] 5,7 DIMETHOXYCHROMEN 4 ONE;
2 [4 (2 HYDROXY 3 PIPERIDIN 1 YL PROPOXY)PHENYL] 5,7 DIMETHOXYCHROMEN 4 ONE;
2 [4 (2 HYDROXY 3 PYRROLIDIN 1 YL PROPOXY)PHENYL] 5,7 DIMETHOXYCHROMEN 4 ONE;
2 [4 (2,3 DIHYDROXYPROPOXY)PHENYL] 5,7 DIMETHOXYCHROMEN 4 ONE;
2 [4 (3 AMINOPROPOXY)PHENYL] 5,7 DIMETHOXYCHROMEN 4 ONE;
2 [4 (3 DIMETHYLAMINO 2 HYDROXYPROPOXY)PHENYL] 5,7 DIMETHOXYCHROMEN 4 ONE;
2 [4 (3 DIMETHYLAMINOPROPOXY)PHENYL] 5,7 DIMETHOXYCHROMEN 4 ONE;
5 HYDROXY 7 METHOXY 2 [4 (2 PYRROLIDIN 1 YL ETHOXY)PHENYL]CHROMEN 4 ONE;
5,7 DIHYDROXY 2 [4 (2 PYRROLIDIN 1 YL ETHOXY)PHENYL]CHROMEN 4 ONE;
5,7 DIMETHOXY 2 (4 OXIRANYLMETHOXYPHENYL)CHROMEN 4 ONE;
5,7 DIMETHOXY 2 [4 (1 METHYLPIPERIDIN 4 YLOXY)PHENYL]CHROMEN 4 ONE;
5,7 DIMETHOXY 2 [4 (2 MORPHOLIN 4 YL ETHOXY)PHENYL]CHROMEN 4 ONE;
5,7 DIMETHOXY 2 [4 (2 PIPERIDIN 1 YL ETHOXY)PHENYL]CHROMEN 4 ONE;
5,7 DIMETHOXY 2 [4 (2 PYRROLIDIN 1 YL ETHOXY)PHENYL]CHROMEN 4 ONE;
5,7 DIMETHOXY 2 [4 (2 PYRROLIDIN 1 YL ETHYLAMINO)PHENYL]CHROMEN 4 ONE;
5,7 DIMETHOXY 2 [4 (PIPERIDIN 4 YLOXY)PHENYL]CHROMEN 4 ONE;
5,7 DIMETHOXY 2 [4 [2 (4 METHYLPIPERAZIN 1 YL)ETHOXY]PHENYL]CHROMEN 4 ONE;
APIGENIN;
APIGENIN DERIVATIVE;
HJC 05100;
HJC 0561;
UNCLASSIFIED DRUG;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ANIMAL TISSUE;
ANTIPROLIFERATIVE ACTIVITY;
APOPTOSIS;
ARTICLE;
CHEMICAL MODIFICATION;
CHRONIC PANCREATITIS;
CONTROLLED STUDY;
CYSTIC FIBROSIS;
DRUG DESIGN;
DRUG EFFICACY;
DRUG POTENCY;
DRUG SOLUBILITY;
DRUG STRUCTURE;
DRUG SYNTHESIS;
HUMAN;
HUMAN CELL;
IN VITRO STUDY;
IN VIVO STUDY;
LOW DRUG DOSE;
MOUSE;
NONHUMAN;
PANCREATIC STELLATE CELL;
CELL CULTURE;
CELL DEATH;
CELL PROLIFERATION;
CHEMICAL STRUCTURE;
CHEMISTRY;
CYTOLOGY;
DOSE RESPONSE;
DRUG EFFECTS;
FIBROSIS;
PANCREATITIS, CHRONIC;
PATHOLOGY;
SOLUBILITY;
STRUCTURE ACTIVITY RELATION;
SYNTHESIS;
APIGENIN;
CELL DEATH;
CELL PROLIFERATION;
CELLS, CULTURED;
DOSE-RESPONSE RELATIONSHIP, DRUG;
DRUG DESIGN;
FIBROSIS;
HUMANS;
MOLECULAR STRUCTURE;
PANCREATIC STELLATE CELLS;
PANCREATITIS, CHRONIC;
SOLUBILITY;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 84901914747
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2014.04.043 Document Type: Article |
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Times cited : (33)
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References (45)
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