Can we expect progress in the treatment of fibrosis in the course of chronic pancreatitis?

Advances in Medical Sciences

Volumn 56, Issue 2, 2011, Pages 132-137

  Madro, A ^a   Slomka, M ^a   Celinski, K ^a  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

chronic pancreatitis; fibrosis; pancreatic stellate cells; renin angiotensin system

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANGIOTENSIN II; APOLIPOPROTEIN E; CANDESARTAN; CELL ADHESION MOLECULE; CYTOKINE; DESMIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN 1; FAT DROPLET; GROWTH FACTOR; HYDROXYPROLINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LISINOPRIL; LOSARTAN; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MYELOPEROXIDASE; NESTIN; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROSTAGLANDIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ACINAR CELL; APOPTOSIS; AUTOCRINE EFFECT; CELL ACTIVATION; CELL DAMAGE; CELL DEATH; CELL LOSS; CELL NUCLEUS; CELL SIZE; CELL STRUCTURE; CHRONIC PANCREATITIS; CYSTIC FIBROSIS; CYTOKINE RELEASE; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; EXTRACELLULAR MATRIX; FIBROGENESIS; HUMAN; INFLAMMATORY INFILTRATE; MONONUCLEAR CELL; NONHUMAN; PANCREAS ISLET CELL; PROTEIN LOCALIZATION; PROTEIN SECRETION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SIGNAL TRANSDUCTION; STELLATE CELL;

EID: 84855451570     PISSN: 18961126     EISSN: 18984002     Source Type: Journal    
DOI: 10.2478/v10039-011-0023-1     Document Type: Review

References (45)

1. Sarles H. Defnitions and classifcations of pancreatitis. Pancreas. 1991 Jul;6(4):470-4.
2. Kleeff J, Friess H, Korc M, Büchler MW. Chronic pancreatitis: pathogenesis and molecular aspects. Ann Ital Chir. 2000 Jan-Feb;71(1):3-10.
3. Tattersall SJN, Apte MV, Wilson JS. A fre inside: current concepts in chronic pancreatitis. Intern Med J. 2008;38(7): 592-8.
4. Andersson R, Tingstedt B, Xia J. Pathogenesis of chronic pancreatitis: a comprehensive update and a look into the future. Scand J Gastroenterol. 2009;44(6):661-3.
5. Di Magno MJ, Di Magno EP. Chronic pancreatitis. Curr Opin Gastroenterol, 2006; 22(5):487-97. (Pubitemid 44197522)
6. Whitcomb DC. Infammation and cancer.V. Chronic pancreatitis and pancreatic cancer. Am J Physiol Gastrointest Liver Physiol. 2004 Aug;287(2):G315-9. (Pubitemid 38955250)
7. Geerts A. History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells. Semin Liver Dis. 2001 Aug;21(3):311-35. (Pubitemid 32923763)
8. Bachem MG, Schneider E, Gross H, Weidenbach H, Schmid RM, Menke A, Siech M, Beger H, Grünert A, Adler G. Identifcation, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology. 1998 Aug;115(2):421-32.
9. Bataller R, Gäbele E, Schoonhoven R, Morris T, Lehnert M, Yang L, Brenner DA, Rippe RA. Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinfammatory events in liver. Am J Physiol Gastrointest Liver Physiol. 2003 Sep;285(3):G642-51. (Pubitemid 37021824)
10. Omary MB, Lugea A, Lowe AW, Pandol SJ. The pancreatic stellate cell: a star on the rise in pancreatic diseases. J Clin Invest. 2007 Jan;117(1):50-9 (Pubitemid 46048449)
11. Jaster R. Molecular regulation of pancreatic stellate cell function. Mol Cancer. 2004; Oct 6;3:26.
12. Phillips PA, Wu MJ, Kumar RK, Doherty E, McCarroll JA, Park S, Pirola RC, Wilson JS, Apte MV. Cell migration: a novel aspect of pancreatic stellate cell biology. Gut. 2003 May;52(5):677-82. (Pubitemid 36528869)
13. Apte M V, Wilson JS. Stellate cell activation in alcoholic pancreatitis. Pancreas. Pancreas. 2003 Nov;27(4):316-20. (Pubitemid 37337897)
14. Masamune A., Shimosegawa T. Signal transduction in pancreatic stellate cells. J Gastroenterol. 2009;44(4):249-60.
15. Kamisawa T, Statke K. Clinical management of autoimmune pancreatitis. Adv Med Sci. 2007;52:61-5.
16. Page IH, Bumpus FM, editors. Angiotensin. New York: Springer-Verlag; 1974.
17. Pollare T, Lithell H, Berne C. A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension. N Engl J Med. 1989 Sep 28;321(13):868-73. (Pubitemid 19238619)
18. Santoro D, Natali A, Palombo C, Brandi LS, Piatti M, Ghione S, Ferrannini E. Effects of chronic angiotensin converting enzyme inhibition on glucose tolerance and insulin sensitivity in essential hypertension. Hypertension. 1992 Aug;20(2):181-91.
19. Leung PS, Chan HC, Wong PY. Immunohistochemical localization of angiotensin II in the mouse pancreas. Histochem J. 1998 Jan;30(1):21-5. (Pubitemid 28154710)
20. Tahmasebi M, Puddefoot JR, Inwang ER, Vinson GP. The tissue renin-angiotensin system in human pancreas. J Endocrinol. 1999 May;161(2):317-22. (Pubitemid 29244259)
21. Yamada T, Kuno A, Ogawa K, Tang M, Masuda K, Nakamura S, Ando T, Okamoto T, Ohara H, Nomura T, Joh T, Shirai T, Itoh M. Combination therapy with an angiotensin-converting enzyme inhibitor and an angiotensin II receptor blocker synergistically suppresses chronic pancreatitis in rats. J Pharmacol Exp Ther. 2005 Apr;313(1):36-45. (Pubitemid 40411325)
22. Kuno A, Yamada T, Masuda K, Ogawa K, Sogawa M, Nakamura S, Nakazawa T, Ohara H, Nomura T, Joh T, Shirai T, Itoh M. Angiotensin-converting enzyme inhibitor attenuates pancreatic infammation and fbrosis in male Wistar Bonn/Kobori rats. Gastroenterology. 2003 Apr;124(4):1010-9. (Pubitemid 36389804)
23. Madro A. Wpływ inhibitorów konwertazy angiotensyny i receptora AT1 na procesy włóknienia i apoptozy w eksperymentalnym przewlekłym zapaleniu trzustki wywołanym dichlorkiem di-n-butylocyny. [master's thesis].[Lublin]: Medical University of Lublin; 2008. 115 p.
24. Shimizu K, Shiratori K, Hayashi N, Kobayashi M, Fujiwara T, Horikoshi H. Thiazolidinedione derivatives as novel therapeutic agents to prevent the development of chronic pancreatitis. Pancreas. 2002 Mar;24(2):184-90. (Pubitemid 34171295)
25. Westerloo DJ, Florquin S, de Boer AM, Daalhuisen J, de Vos AF, Bruno MJ, van der Poll T. Therapeutic effects of troglitazone in experimental chronic pancreatitis in mice. Am J Pathol. 2005 Mar;166(3):721-8. (Pubitemid 40315629)
26. Leung PS. The physiology of a local renin-angiotensin system in the pancreas. J Physiol. 2007 Apr 1;580(Pt 1):31-7. (Pubitemid 46470642)
27. Chan WP, Fung ML, Nobiling R, Leung PS. Activation of local rennin-angiotensin system by chronic hypoxia. Mol Cell Endocrinol. 2000 Feb 25;160(1-2):107-14. (Pubitemid 30129057)
28. Ip SP, Kwan PC, Williams CH, Pang S, Hooper NM, Leung PS. Changes of angiotensin-converting enzyme activity in the pancreas of chronic hypoxia and acute pancreatitis. Inter J Bioch Cell Biol. 2003 Jun;35(6):944-54. (Pubitemid 36379333)
29. Leung PS, Chan WP, Nobiling R. Regulated expression of pancreatic rennin-angiotensin system in experimental pancreatitis. Mol Cell Endocrinol. 2000 Aug 30;166(2):121-8.
30. Tsang SW, Cheng CH, Leung PS. The role of the pancreatic rennin-angiotensin system in acinar digestive enzyme secretion and in acute pancreatitis. Regul Pept. 2004 Jul 15;119(3):213-9. (Pubitemid 38553840)
31. Chan HC, Law SH, Leung PS, Wong P.D. Angiotensin II receptor type I-regulated anion secretion in cystic fbrosis pancreatic duct cells. J Memb Biol. 1997;156:241-50.
32. Wang XP, Zhang R, Wu K, Wu L, Dong Y. Angiotensin II mediates acinar cell apoptosis during the development of rat pancreatic fbrosis by AT1R. Pancreas; 1997 Apr 1;156(3):241-9.
33. Ko SH, Hong OK, Kim JW, Ahn YB, Song KH, Cha BY, Son HY, Kim MJ, Jeong IK, Yoon KH. High glucose increases extracellular matrix production in pancreatic stellate cells by activating the rennin-angiotenin system. J Cell Biochem. 2006 May 15;98(2):343-55.
34. Tikellis C, Cooper ME, Thomas MC. Role of the rennin-angiotensin system in the endocrine pancreas: implications for the development of diabetes. Int J Biochem Cell Biol. 2006;38(5-6):737-51. (Pubitemid 43363410)
35. Lau T, Carlsson PO, Leung PS. Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets. Diabetologia. 2004 Feb;47(2):240-8. (Pubitemid 38315360)
36. Kamp C, Lau T, Olsson R, Leung PS, Carlsson PO. Angiotensin II type 1 receptor inhibition markedly improves the blood perfusion, oxygen tension and frst phase of glucose-stimulated insulin secretion in revascularised syngeneic mouse islet grafts. Diabetologia; 2005 Jun;48(6):1159-67. (Pubitemid 40909652)
37. Lam KY, Leung PS. Regulation and expression of rennin-angiotensin system in human pancreas and pancreatic endocrine tumours. Eur J Endocrinol. 2002 Apr;146(4):567-72 (Pubitemid 34436471)
38. Masamune A, Sakai Y, Kikuta K, Satoh M, Satoh A, Shimosegawa T. Pancreatic stellate cells express Toll-like receptors. J Gastroenterol. 2008;43(5):352-62. (Pubitemid 351958899)
39. Masamune A, Kikuta K, Satoh M, Satoh K, Shimosegawa T. Rho kinase inhibitors block activation of pancreatic stellate cells. Br J Pharmacol. 2003 Dec;140(7):1292-302. (Pubitemid 38117434)
40. Hama K, Ohnishi H, Yasuda H, Ueda N, Mashima H, Satoh Y, Hanatsuka K, Kita H, Ohashi A, Tamada K, Sugano K. Angiotensin II stimulates DNA synthesis of rat pancreatic stellate cells by activating ERK through EGF receptor transactivation. Biochem Biophys Res Commun. 2004 Mar 19;315(4):905-11. (Pubitemid 38249389)
41. McCarroll JA, Phillips PA, Santucci N, Pirola RC, Wilson JS, Apte M V. Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fbrosis. Gut. 2006 Jan;55(1):79-89. (Pubitemid 41820640)
42. Phillips PA, McCarroll JA, Park S, Wu MJ, Pirola R, Korsten M, Wilson JS, Apte MV. Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover. Gut. 2003 Feb;52(2):275-82. (Pubitemid 36115072)
43. Nishida A, Andoh A, Shioya M, Kim-Mitsuyama S, Takayanagi A, Fujiyama Y. Phosphatidylinositol 3-kinase/Akt signaling mediates interleukin-32alpha induction in human pancreatic periacinar myofbroblasts. Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G831-8. (Pubitemid 351468765)
44. Yu JH, Kim KH, Kim H. Suppression of IL-1beta expression by the Jak 2 inhibitor AG490 in cerulein-stimulated pancreatic acinar cells.Biochem Pharmacol. 2006 Nov 30;72(11):1555-62. (Pubitemid 44755147)
45. Suzuki N, Masamune A, Kikuta K, Watanabe T, Satoh K, Shimosegawa T. Ellagic acid inhibits pancreatic fbrosis in male Wistar Bonn/Kobori rats. Dig Dis Sci. 2009 Apr;54(4):802-10.