Quantitative analysis of [carbonyl-11C]WAY-100635 PET studies

Nuclear Medicine and Biology

Volumn 27, Issue 5, 2000, Pages 477-482

  Gunn, Roger N ^a   Lammertsma, Adriaan A ^b   Grasby, Paul M ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

5 HT(1A) receptor; carbonyl 11C WAY 100635; Modeling; PET

Indexed keywords

N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; RADIOLIGAND; SEROTONIN 1A RECEPTOR;

ADULT; ARTICLE; BINDING AFFINITY; BRAIN BLOOD FLOW; CHEMICAL ANALYSIS; COMPARTMENT MODEL; CONTROLLED STUDY; HUMAN; IMAGE ANALYSIS; IN VIVO STUDY; KINETICS; MALE; METABOLISM; METABOLITE; MODEL; NORMAL HUMAN; PLASMA CLEARANCE; POSITRON EMISSION TOMOGRAPHY; QUANTITATIVE ASSAY; STOICHIOMETRY;

ADULT; CARBON RADIOISOTOPES; HUMANS; LIGANDS; MALE; MIDDLE AGED; PIPERAZINES; PYRIDINES; SEROTONIN ANTAGONISTS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0033835156     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(00)00115-3     Document Type: Article

References (33)

1. 11C]NNC 756. Synapse. 32:1999;93-109.
2. 11C]-WAY-100635. J. Cereb. Blood Flow Metab. 17:1997;S327.
3. Cunningham V. J. and Lammertsma A. A. 1995. Radioligand studies in brain: Kinetic analysis of PET data. Med. Chem. Res. 5, 79-96.
4. Drevets W.C., Frank E., Price J.C., Kupfer D.J., Holt D., Greer P.J., Huang Y., Gautier C., Mathis C. PET imaging of serotonin 1A receptor binding in depression. Biol. Psychiatry. 46:1999;1375-1387.
5. 1A receptors in the primate brain. Psychopharmacology 133, 196-202.
6. Farde L., Ito H., Swahn C.G., Pike V.W., Halldin C. Quantitative analyses of carbonyl-carbon-11-WAY-100635 binding to central 5-hydroxytryptamine-1A receptors in man. J. Nucl. Med. 39:1998;1965-1971.
7. 1A receptor antagonist, WAY-100635. Eur. J. Pharmacol. 281:1995;81-88.
8. Friston K.J., Holmes A.P., Price C.J., Buchel C., Worsley K.J. Multisubject fMRI studies and conjunction analyses. NeuroImage. 10:1999;385-396.
9. Gunn R.N., Lammertsma A.A., Hume S.P., Cunningham V.J. Parametric imaging of ligand-receptor binding in PET using a simplified reference region model. NeuroImage. 6:1997;279-287.
10. 11C]WAY-100635 for PET. NeuroImage 8, 426-440.
11. 1A receptor. In Physiological Imaging of the Brain with PET (Edited by Gjedde et al.), pp. 171-176. Academic Press, San Diego.
12. 11C]WAY-100635. Brain Res. 745:1997;96-108.
13. 1A receptors measured in vivo using small animal positron emission tomography with carbon-11 labelled WAY 100635. Synapse 36330-341.
14. 1A receptors in rat brain. Eur. J. Pharmacol. 271, 515-523.
15. Hume S. P., Gunn R. N. and Jones T. (1997.) Pharmacological constraints associated with PET scanning of small laboratory animals. Eur. J. Nucl. Med. 25, 173-176.
16. Kety S.S., Schmidt C.F. The nitrous oxide method for the quantitative determination of cerebral blood flow in man Theory, procedure and normal values . J. Clin. Invest. 27:1948;476-483.
17. 1A receptor antagonist, to rat brain. J. Neurochem. 64:1995;2716-2726.
18. Lammertsma A.A., Hume S.P. Simplified reference tissue model for PET receptor studies. NeuroImage. 4:1996;153-158.
19. 11C]raclopride studies. J. Cereb. Blood Flow Metab. 16, 42-52.
20. 3H]WAY 100635 in the mouse. Eur. J. Pharmacol. 271:1994;505-514.
21. Laruelle M. Modelling When and why? Eur. J. Nucl. Med. 26:1999;571-572.
22. Leenders K.L., Perani D., Lammertsma A.A., Heather J.D., Buckingham P., Healy M.J.R., Gibbs J.M., Wise R.S.J., Hatazawa J., Herold S., Beaney R.P., Brooks D.J., Spinks T., Rhodes C., Frackowiak R.S.J., Jones T. Cerebral blood flow, blood volume and oxygen utilization Normal values and effect of age . Brain. 113:1990;27-47.
23. Martinez D., Mawlawi O., Hwang D.-R., Kent J., Simpson N., Parsey R.V., Slifstein M., Huang Y., Van Heertum R., Abi-Dargham A., Caltabiano S., Malizia A., Cowley H., Mann J.J., Laruelle M. Positron emission tomography study of pindolol occupancy of 5-HT1A receptors in humans Preliminary analyses . Nucl. Med. Biol. 27:2000;523-527.
24. Meyer J. H., Gunn R. N., Myers R. and Grasby P. M. (1999.) Assessment of spatial normalization of PET ligand images using ligand-specific templates. NeuroImage. 9, 545-553.
25. Mintun M.A., Raichle M.E., Kilbourn M.R., Wooten G.F., Welch M.J. A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann. Neurol. 15:1984;217-227.
26. 11C]WAY-100635 - Explanation of high signal contrast in PET and an aid to biomathematical modelling. Nucl. Med. Biol. 25:1998;215-223.
27. 11C]WAY-100635. Med. Chem. Res. 5:1995;208-277.
28. 11C]WAY-100635. Eur. J. Pharmacol. 301:1996;R5-R7.
29. 11C]WAY 100635 and PET. In Quantification of Brain Function Using PET (Edited by Myers R., Cunningham V., Bailey D. and Jones T.), pp. 257-261. Academic Press, San Diego.
30. 11C]WAY-100635 PET study. J. Cereb. Blood Flow Metab. 19 (suppl 1), S324.
31. 11C]WAY-100635: Effects of depression and antidepressant treatment. Arch. Gen. Psychiatry 57, 174-180.
32. 11C]WAY-100635 binding parameters with reference tissue models Effect of variations of model assumptions . Nucl. Med. Biol. 27:2000;487-492.
33. 14C-deoxyglucose method for the measurement of local cerebral glucose utilisation Theory, procedure and normal values in the conscious and anaesthetized albino rat . J. Neurochem. 28:1977;897-916.