A TPGS-incorporating nanoemulsion of paclitaxel circumvents drug resistance in breast cancer

International Journal of Pharmaceutics

Volumn 471, Issue 1-2, 2014, Pages 206-213

  Bu, Huihui ^a   He, Xinyu ^a   Zhang, Zhiwen ^a   Yin, Qi ^a   Yu, Haijun ^a   Li, Yaping ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Breast cancer; Multidrug resistance; Nanoemulsion; Paclitaxel; Self assembly; TPGS

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA TOCOPHEROL SUCCINATE; CASPASE 3; DEXTRO ALPHA TOCOPHERYL POLYETHYLENE GLYCOL 1000 SUCCINATE; MACROGOL; MULTIDRUG RESISTANCE PROTEIN; PACLITAXEL; UNCLASSIFIED DRUG; ALPHA TOCOPHEROL; ANTINEOPLASTIC AGENT; DRUG CARRIER; EMULSION; NANOMATERIAL; TOCOFERSOLAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MCF 7 CELL LINE; MOUSE; NANOEMULSION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR XENOGRAFT; ANIMAL; BIOSYNTHESIS; CELL CYCLE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; EMULSION; IC50; MAMMARY NEOPLASMS, EXPERIMENTAL; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; NUDE MOUSE; PATHOLOGY;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL CYCLE; CELL SURVIVAL; DRUG CARRIERS; DRUG RESISTANCE, NEOPLASM; EMULSIONS; HUMANS; INHIBITORY CONCENTRATION 50; MAMMARY NEOPLASMS, EXPERIMENTAL; MCF-7 CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE, NUDE; NANOSTRUCTURES; P-GLYCOPROTEIN; PACLITAXEL; VITAMIN E; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84901847134     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.05.039     Document Type: Article

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