Solid dispersion of berberine-phospholipid complex/TPGS 1000/SiO 2: Preparation, characterization and in vivo studies

International Journal of Pharmaceutics

Volumn 465, Issue 1-2, 2014, Pages 306-316

  Zhang, Zhenhai ^a,b   Chen, Yan ^b   Deng, Jin ^b   Jia, Xiaobin ^a   Zhou, Jianping ^b   Lv, Huixia ^b  

^a Key Laboratory of New Drug Delivery System of Chinese Materia Medica   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Berberine; P glycoprotein; Phospholipid complex; Silica; Solid dispersions; TPGS 1000

Indexed keywords

ALPHA TOCOPHERYL POLYETHYLENE GLYCOL 1000; BERBERINE; BERBERINE PHOSPHOLIPID COMPLEX; PHOSPHOLIPID; SILICON DIOXIDE; SURFACTANT; UNCLASSIFIED DRUG; ALPHA TOCOPHEROL; ALPHA-TOCOPHERYL POLYETHYLENE GLYCOL SUCCINATE; DRUG CARRIER; DRUG DOSAGE FORM; MACROGOL DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; COLON; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG ABSORPTION; DRUG SOLUBILITY; DUODENUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ILEUM; IN VITRO STUDY; INTESTINE ABSORPTION; INTESTINE PERFUSION; JEJUNUM; MALE; MAXIMUM PLASMA CONCENTRATION; NEAR INFRARED SPECTROSCOPY; NONHUMAN; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; TIME TO MAXIMUM PLASMA CONCENTRATION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOAVAILABILITY; CHEMISTRY; DRUG DOSAGE FORM; DRUG EFFECTS; EVALUATION STUDY; INFRARED SPECTROSCOPY; INTESTINE; MEDICINAL CHEMISTRY; METABOLISM; ORAL DRUG ADMINISTRATION; PHARMACEUTICS; PROCEDURES; SOLUBILITY; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; BERBERINE; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; DOSAGE FORMS; DRUG CARRIERS; INTESTINAL ABSORPTION; INTESTINES; MALE; MICROSCOPY, ELECTRON, SCANNING; P-GLYCOPROTEIN; PHOSPHOLIPIDS; POLYETHYLENE GLYCOLS; RATS, SPRAGUE-DAWLEY; SILICON DIOXIDE; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TECHNOLOGY, PHARMACEUTICAL; VITAMIN E;

EID: 84897954652     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.01.023     Document Type: Article

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