Multifunctional nanoemulsion platform for imaging guided therapy evaluated in experimental cancer

ACS Nano

Volumn 5, Issue 6, 2011, Pages 4422-4433

  Gianella, Anita ^a,b   Jarzyna, Peter A ^a   Mani, Venkatesh ^a   Ramachandran, Sarayu ^a   Calcagno, Claudia ^a   Tang, Jun ^a   Kann, Benjamin ^a   Dijk, Wouter J R ^a   Thijssen, Victor L ^c   Griffioen, Arjan W ^c   Storm, Gert ^d   Fayad, Zahi A ^a   Mulder, Willem J M ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b CENTRO CARDIOLOGICO MONZINO   (Italy)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

cancer nanotherapy; glucocorticoids; multimodal imaging; nanoemulsions; theranostics

Indexed keywords

CANCER NANOTHERAPY; GLUCOCORTICOIDS; MULTIMODAL IMAGING; NANOEMULSIONS; THERANOSTICS;

BIOCHEMISTRY; DISEASES; IRON OXIDES; MAMMALS; NANOCRYSTALS; NANOPARTICLES; RATING; TUMORS;

MAGNETIC RESONANCE IMAGING;

ARGINYL-GLYCYL-ASPARTIC ACID; ARGINYLGLYCYLASPARTIC ACID; DRUG CARRIER; DRUG DERIVATIVE; GLUCOCORTICOID; LIPID; OLIGOPEPTIDE; PREDNISOLONE; PREDNIVAL ACETATE;

ANIMAL; ARTICLE; CANCER TRANSPLANTATION; CHEMISTRY; COLON TUMOR; EMULSION; EXPERIMENTAL NEOPLASM; METHODOLOGY; MOUSE; NANOMEDICINE; NEOVASCULARIZATION (PATHOLOGY); NUCLEAR MAGNETIC RESONANCE IMAGING; ONCOLOGY; PATHOLOGY; PHOTON; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; COLONIC NEOPLASMS; DRUG CARRIERS; EMULSIONS; GLUCOCORTICOIDS; LIPIDS; MAGNETIC RESONANCE IMAGING; MEDICAL ONCOLOGY; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; NANOMEDICINE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; OLIGOPEPTIDES; PHOTONS; PREDNISOLONE;

EID: 79959784183     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn103336a     Document Type: Article

References (51)

1. Cormode, D. P.; Skajaa, T.; Fayad, Z. A.; Mulder, W. J. M. Nanotechnology in Medical Imaging Probe Design and Applications Arterioscl., Thromb., Vasc. Biol. 2009, 29, 992-1000
2. Jarzyna, P. A.; Gianella, A.; Skajaa, T.; Knudsen, G.; Deddens, L. H.; Cormode, D. P.; Fayad, Z. A.; Mulder, W. J. M. Multifunctional Imaging Nanoprobes Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol. 2010, 2, 138-150
3. Strijkers, G. J.; Mulder, W. J.; van Tilborg, G. A.; Nicolay, K. MRI Contrast Agents: Current Status and Future Perspectives Anticancer Agents Med. Chem. 2007, 7, 291-305 (Pubitemid 46813466)
4. Mulder, W. J.; Strijkers, G. J.; van Tilborg, G. A.; Griffioen, A. W.; Nicolay, K. Lipid-Based Nanoparticles for Contrast-Enhanced MRI and Molecular Imaging NMR Biomed. 2006, 19, 142-164 (Pubitemid 43250800)
5. Medarova, Z.; Pham, W.; Farrar, C.; Petkova, V.; Moore, A. In Vivo Imaging of SiRNA Delivery and Silencing in Tumors Nat. Med. 2007, 13, 372-377 (Pubitemid 46376679)
6. Mitra, A.; Nan, A.; Line, B. R.; Ghandehari, H. Nanocarriers for Nuclear Imaging and Radiotherapy of Cancer Curr. Pharm. Des. 2006, 12, 4729-4749 (Pubitemid 44841764)
7. Pan, D.; Lanza, G. M.; Wickline, S. A.; Caruthers, S. D. Nanomedicine: Perspective and Promises with Ligand-Directed Molecular Imaging Eur. J. Radiol. 2009, 70, 274-285
8. Hartman, K. B.; Wilson, L. J.; Rosenblum, M. G. Detecting and Treating Cancer with Nanotechnology Mol. Diagn. Ther. 2008, 12, 1-14 (Pubitemid 351281695)
9. Bhojani, M. S.; Van Dort, M.; Rehemtulla, A.; Ross, B. D. Targeted Imaging and Therapy of Brain Cancer Using Theranostic Nanoparticles Mol. Pharmaceutics 2010, 7, 1921-1929
10. Alexis, F.; Pridgen, E.; Molnar, L. K.; Farokhzad, O. C. Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles Mol. Pharmaceutics 2008, 5, 505-515
11. Alexis, F.; Pridgen, E. M.; Langer, R.; Farokhzad, O. C. Nanoparticle Technologies for Cancer Therapy Handb. Exp. Pharmacol. 2010, 55-86
12. Allen, T. M. Long-Circulating (Sterically Stabilized) Liposomes for Targeted Drug-Delivery Trends Pharmacol. Sci. 1994, 15, 215-220 (Pubitemid 24210725)
13. Mozafari, M. R.; Pardakhty, A.; Azarmi, S.; Jazayeri, J. A.; Nokhodchi, A.; Omri, A. Role of Nanocarrier Systems in Cancer Nanotherapy J. Liposome Res. 2009, 19, 310-321
14. Brannon-Peppas, L.; Blanchette, J. O. Nanoparticle and Targeted Systems for Cancer Therapy Adv. Drug Delivery Rev. 2004, 56, 1649-1659 (Pubitemid 39177694)
15. Ahmad, M. Z.; Akhter, S.; Jain, G. K.; Rahman, M.; Pathan, S. A.; Ahmad, F. J.; Khar, R. K. Metallic Nanoparticles: Technology Overview & Drug Delivery Applications in Oncology Expert Opin. Drug Delivery 2010, 7, 927-942
16. Gelderblom, H.; Verweij, J.; Nooter, K.; Sparreboom, A. Cremophor El: The Drawbacks and Advantages of Vehicle Selection for Drug Formulation Eur. J. Cancer 2001, 37, 1590-1598 (Pubitemid 32778603)
17. Banciu, M.; Fens, M. H. A. M.; Storm, G.; Schiffelers, R. M. Antitumor Activity and Tumor Localization of Liposomal Glucocorticoids in B16 Melanoma-Bearing Mice J. Controlled Release 2008, 127, 131-136
18. Banciu, M.; Metselaar, J. M.; Schiffelers, R. M.; Storm, G. Liposomal Glucocorticoids as Tumor-Targeted Anti-Angiogenic Nanomedicine in B16 Melanoma-Bearing Mice J. Steroid Biochem. Mol. Biol. 2008, 111, 101-110
19. Wolff, J. E.; Guerin, C.; Laterra, J.; Bressler, J.; Indurti, R. R.; Brem, H.; Goldstein, G. W. Dexamethasone Reduces Vascular Density and Plasminogen Activator Activity in 9l Rat Brain Tumors Brain Res. 1993, 604, 79-85 (Pubitemid 23080100)
20. Badruddoja, M. A.; Krouwer, H. G. J.; Rand, S. D.; Rebro, K. J.; Pathak, A. P.; Schmainda, K. M. Antiangiogenic Effects of Dexamethasone in 9l Gliosarcoma Assessed by MRI Cerebral Blood Volume Maps Neuro-Oncology 2003, 5, 235-243 (Pubitemid 37265903)
21. Schiffelers, R. M.; Banciu, M.; Metselaar, J. M.; Storm, G. Therapeutic Application of Long-Circulating Liposomal Glucocorticoids in Auto-Immune Diseases and Cancer J. Liposome Res. 2006, 16, 185-194 (Pubitemid 44358992)
22. Jarzyna, P. A.; Skajaa, T.; Gianella, A.; Cormode, D. P.; Samber, D. D.; Dickson, S. D.; Chen, W.; Griffioen, A. W.; Fayad, Z. A.; Mulder, W. J. M. Iron Oxide Core Oil-in-Water Emulsions as a Multifunctional Nanoparticle Platform for Tumor Targeting and Imaging Biomaterials 2009, 30, 6947-6954
23. Goulet, O.; Antebi, H.; Wolf, C.; Talbotec, C.; Alcindor, L. G.; Corriol, O.; Lamor, M.; Colomb-Jung, V. A New Intravenous Fat Emulsion Containing Soybean Oil, Medium-Chain Triglycerides, Olive Oil, and Fish Oil: A Single-Center, Double-Blind Randomized Study on Efficacy and Safety in Pediatric Patients Receiving Home Parenteral Nutrition J. Parenter. Enteral Nutr. 2010, 34, 485-495
24. Kok, M. B.; Hak, S.; Mulder, W. J. M.; van der Schaft, D. W. J.; Strijkers, G. J.; Nicolay, K. Cellular Compartmentalization of Internalized Paramagnetic Liposomes Strongly Influences Both T-1 and T-2 Relaxivity Magn. Reson. Med. 2009, 61, 1022-1032
25. Brooks, P. C.; Clark, R. A. F.; Cheresh, D. A. Requirement of Vascular Integrin αVβ3 for Angiogenesis Science 1994, 264, 569-571
26. Mulder, W. J.; Strijkers, G. J.; Habets, J. W.; Bleeker, E. J.; van der Schaft, D. W.; Storm, G.; Koning, G. A.; Griffioen, A. W.; Nicolay, K. MR Molecular Imaging and Fluorescence Microscopy for Identification of Activated Tumor Endothelium Using a Bimodal Lipidic Nanoparticle FASEB J. 2005, 19, 2008-2010 (Pubitemid 41759747)
27. McCarty, O. J.; Mousa, S. A.; Bray, P. F.; Konstantopoulos, K. Immobilized Platelets Support Human Colon Carcinoma Cell Tethering, Rolling, and Firm Adhesion under Dynamic Flow Conditions Blood 2000, 96, 1789-1797 (Pubitemid 30661063)
28. Fendler, J. H.; Romero, A. Liposomes as Drug Carriers Life Sci. 1977, 20, 1109-1120 (Pubitemid 8086779)
29. Anton, A.; Ruiz, A.; Segui, M. A.; Calvo, L.; Munoz, M.; Lao, J.; Sancho, F.; Fernandez, L. Phase I Clinical Trial of Liposomal-Encapsulated Doxorubicin Citrate and Docetaxel, Associated with Trastuzumab, as Neo-Adjuvant Treatment in Stages II and IIIa, Her2-Overexpressing Breast Cancer Patients. Geicam 2003-03 Study Ann. Oncol. 2009, 20, 454-459
30. Hashizume, H.; Baluk, P.; Morikawa, S.; McLean, J. W.; Thurston, G.; Roberge, S.; Jain, R. K.; McDonald, D. M. Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness Am. J. Pathol. 2000, 156, 1363-1380 (Pubitemid 30660013)
31. Maeda, H.; Wu, J.; Sawa, T.; Matsumura, Y.; Hori, K. Tumor Vascular Permeability and the EPR Effect in Macromolecular Therapeutics: A Review J. Controlled Release 2000, 65, 271-284 (Pubitemid 30122932)
32. Ruoslahti, E.; Pierschbacher, M. D. Arg-Gly-Asp: A Versatile Cell Recognition Signal Cell 1986, 44, 517-518
33. Kok, R. J.; Schraa, A. J.; Bos, E. J.; Moorlag, H. E.; Asgeirsdottir, S. A.; Everts, M.; Meijer, D. K. F.; Molema, G. Preparation and Functional Evaluation of Rgd-Modified Proteins as αVβ3 Integrin Directed Therapeutics Bioconjugate Chem. 2002, 13, 128-135 (Pubitemid 34119644)
34. Griffioen, A. W.; Molema, G. Angiogenesis: Potentials for Pharmacologic Intervention in the Treatment of Cancer, Cardiovascular Diseases, and Chronic Inflammation Pharmacol. Rev. 2000, 52, 237-268 (Pubitemid 30368433)
35. Molema, G.; Griffioen, A. W. Rocking the Foundations of Solid Tumor Growth by Attacking the Tumors Blood Supply Immunol. Today 1998, 19, 392-394 (Pubitemid 28389700)
36. Chen, W.; Jarzyna, P. A.; van Tilborg, G. A. F.; Nguyen, V. A.; Cormode, D. P.; Klink, A.; Griffioen, A. W.; Randolph, G. J.; Fisher, E. A.; Mulder, W. J. M. et al. Rgd Peptide Functionalized and Reconstituted High-Density Lipoprotein Nanoparticles as a Versatile and Multimodal Tumor Targeting Molecular Imaging Probe FASEB J. 2010, 24, 1689-1699
37. Mulder, W. J. M.; Castermans, K.; van Beijnum, J. R.; Egbrink, M. G. A. O.; Chin, P. T. K.; Fayad, Z. A.; Lowik, C. W. G. M.; Kaijzel, E. L.; Que, I.; Storm, G. et al. Molecular Imaging of Tumor Angiogenesis Using αVβ3-Integrin Targeted Multimodal Quantum Dots Angiogenesis 2009, 12, 17-24
38. van Tilborg, G. A. F.; Mulder, W. J. M.; van der Schaft, D. W. J.; Reutelingsperger, C. P. M.; Griffioen, A. W.; Strijkers, G. J.; Nicolay, K. Improved Magnetic Resonance Molecular Imaging of Tumor Angiogenesis by Avidin-Induced Clearance of Nonbound Bimodal Liposomes Neoplasia 2008, 10, 1459-1469
39. Liu, S. Radiolabeled Multimeric Cyclic Rgd Peptides as Integrin αVβ3 Targeted Radiotracers for Tumor Imaging Mol. Pharmaceutics 2006, 3, 472-487 (Pubitemid 44639125)
40. Sipkins, D. A.; Cheresh, D. A.; Kazemi, M. R.; Nevin, L. M.; Bednarski, M. D.; Li, K. C. P. Detection of Tumor Angiogenesis In Vivo by αVβ3-Targeted Magnetic Resonance Imaging Nat. Med. 1998, 4, 623-626 (Pubitemid 28237365)
41. Voronov, E.; Shouval, D. S.; Krelin, Y.; Cagnano, E.; Benharroch, D.; Iwakura, Y.; Dinarello, C. A.; Apte, R. N. Il-1 Is Required for Tumor Invasiveness and Angiogenesis Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 2645-2650 (Pubitemid 36297552)
42. Chen, J. J. W.; Yao, P. L.; Yuan, A.; Hong, T. M.; Shun, C. T.; Kuo, M. L.; Lee, Y. C.; Yang, P. C. Up-Regulation of Tumor Interleukin-8 Expression by Infiltrating Macrophages: Its Correlation with Tumor Angiogenesis and Patient Survival in Non-Small Cell Lung Cancer Clin. Cancer Res. 2003, 9, 729-737 (Pubitemid 36182607)
43. Leek, R. D.; Harris, A. L. Tumor-Associated Macrophages in Breast Cancer J. Mammary Gland Biol. Neoplasia 2002, 7, 177-189 (Pubitemid 38420774)
44. Coughlin, C. M.; Salhany, K. E.; Wysocka, M.; Aruga, E.; Kurzawa, H.; Chang, A. E.; Hunter, C. A.; Fox, J. C.; Trinchieri, G.; Lee, W. M. F. Interleukin-12 and Interleukin-18 Synergistically Induce Murine Tumor Regression Which Involves Inhibition of Angiogenesis J. Clin. Invest. 1998, 101, 1441-1452 (Pubitemid 28145262)
45. Cornelius, L. A.; Nehring, L. C.; Harding, E.; Bolanowski, M.; Welgus, H. G.; Kobayashi, D. K.; Pierce, R. A.; Steven, D.; Shapiro, S. D. Matrix Metalloproteinases Generate Angiostatin: Effects on Neovascularization J. Immunol. 1998, 161, 6845-6852 (Pubitemid 28562229)
46. Dirkx, A. E. M.; Egbrink, M. G. A. O.; Wagstaff, J.; Griffioen, A. W. Monocyte/Macrophage Infiltration in Tumors: Modulators of Angiogenesis J. Leukocyte Biol. 2006, 80, 1183-1196 (Pubitemid 44904956)
47. Shimura, S.; Yang, G.; Ebara, S.; Wheeler, T. M.; Frolov, A.; Thompson, T. C. Reduced Infiltration of Tumor-Associated Macrophages in Human Prostate Cancer: Association with Cancer Progression Cancer Res. 2000, 60, 5857-5861
48. Migita, T.; Sato, E.; Saito, K.; Mizoi, T.; Shiiba, K.; Matsuno, S.; Nagura, H.; Ohtani, H. Differing Expression of Mmps-1 and -9 and Urokinase Receptor between Diffuse- and Intestinal-Type Gastric Carcinoma Int. J. Cancer 1999, 84, 74-79 (Pubitemid 29059112)
49. Melder, R. J.; Koenig, G. C.; Witwer, B. P.; Safabakhsh, N.; Munn, L. L.; Jain, R. K. During Angiogenesis, Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor Regulate Natural Killer Cell Adhesion to Tumor Endothelium Nat. Med. 1996, 2, 992-997 (Pubitemid 26306837)
50. Griffioen, A. W.; Damen, C. A.; Blijham, G. H.; Groenewegen, G. Tumor Angiogenesis Is Accompanied by a Decreased Inflammatory Response of Tumor-Associated Endothelium Blood 1996, 88, 667-673 (Pubitemid 26240398)
51. Forte, T. M.; Nordhausen, R. W. Electron Microscopy of Negatively Stained Lipoproteins Methods Enzymol. 1986, 128, 442-457 (Pubitemid 16100910)