Novel synthesis of dihydropyrimidines for α-glucosidase inhibition to treat type 2 diabetes: In vitro biological evaluation and in silico docking

Bioorganic Chemistry

Volumn 54, Issue , 2014, Pages 96-104

  Yar, Muhammad ^a   Bajda, Marek ^b,c   Shahzadi, Lubna ^a   Shahzad, Sohail Anjum ^d   Ahmed, Maqsood ^e   Ashraf, Muhammad ^e   Alam, Umber ^e   Khan, Islam Ullah ^f   Khan, Ather Farooq ^a  

^a Process and Energy Systems Engineering Center PRESTIGE   (Pakistan)

^b UNIVERSITY OF WARSAW   (Poland)

^c JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^d Department of Chemistry COMSATS Institute of Information Technology ^*  (Pakistan)

^e THE ISLAMIA UNIVERSITY OF BAHAWALPUR   (Pakistan)

^f GC UNIVERSITY   (Pakistan)

Author keywords

Acarbose; Biginelli reaction; Dihydropyrimidine; N acetyl glycine; Glucosidase inhibitors

Indexed keywords

2,6 METHANO 4 OXO 3,4,5,6 TETRAHYDRO 2H [1,3,5]BENZOXADIAZOCINE; 2,6 METHANO 4 THIOXO 3,4,5,6 TETRAHYDRO 2H [1,3,5]BENZOXADIAZOCINE; ALPHA GLUCOSIDASE; ANTIDIABETIC AGENT; ETHYL 4 (4 CHLOROPHENYL) 6 METHYL 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (4 HYDROXY 3 METHOXYPHENYL) 6 METHYL 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (4 HYDROXY 3 METHOXYPHENYL) 6 METHYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (4 METHOXYPHENYL) 6 METHYL 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (4 METHOXYPHENYL) 6 METHYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 6 METHYL 2 OXO 4 PHENYL 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 6 METHYL 4 (4 METHYLPHENYL) 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 6 METHYL 4 (4 METHYPHENYL) 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 6 METHYL 4 PHENYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; 1,4-DIHYDROPYRIMIDINE; GLYCOSIDASE INHIBITOR;

ARTICLE; BINDING AFFINITY; COMPUTER MODEL; CONTROLLED STUDY; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; MOLECULAR DOCKING; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; DIABETES MELLITUS, TYPE 2; DOSE RESPONSE; ENZYMOLOGY; METABOLISM; MOLECULAR GENETICS; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ALPHA-GLUCOSIDASES; AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOSIDE HYDROLASE INHIBITORS; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PYRIMIDINES; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84901844826     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2014.05.003     Document Type: Article

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